CAS: 421-50-1; 1,1,1-Trifluoroacetone

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三氟乙酰乙酸乙酯置于硫酸体系中,用 水 作为反应溶剂,化学反应生成 1,1,1-三氟丙酮
参考文献:从催产克雷伯菌中选择,纯化,表征和克隆一种新型热稳定立体特异性酰胺酶,及其在对映体纯 (R)-和 (S)-3,3,3-Trifluoro-2-合成中的应用羟基-2-甲基丙酸和 (S)-3,3,3-三氟-2-羟基-2-甲基丙酰胺
标题:从催产克雷伯菌中选择,纯化,表征和克隆一种新型热稳定立体特异性酰胺酶,及其在对映体纯 (R)-和 (S)-3,3,3-Trifluoro-2-合成中的应用羟基-2-甲基丙酸和 (S)-3,3,3-三氟-2-羟基-2-甲基丙酰胺
摘要:我们从产酸克雷伯菌中分离,表征和克隆了一种对映体特异性酰胺酶,并用它来解析 (R,S)-3,3,3-Trifluoro-2-Hydroxy-2-Methylpropionamide,得到 (R)-3,3,3-三氟-2-羟基-2-甲基丙酸和 (S)-3,3,3-三氟-2-羟基-2-甲基丙酰胺.然后可以将(S)-酰胺化学水解成(S)-3,3,3-三氟-2-羟基-2-甲基丙酸.因此,该方法可适用于生产 3,3,3-三氟-2-羟基-2-甲基丙酸或 (S)-3,3,3-三氟-的 (R)-和 (S)-对映异构体2-羟基-2-甲基丙酰胺.生物催化步骤是从三氟乙酰乙酸乙酯开始的化学和生物催化组合路线的一部分.产品通常具有大于 98% 的纯度,分离后的 Ee 值基本为 100%.
DOI:10.1021/op020025D

专利信息

专利号:US-2025197202-A1
优先权日:2023-12-15
标题 :Synthesis of new polymers for the manufacture of solid hydrogen transfer agents
发明人：GÓMEZ EMILIO LEAL; MANCERA LEÓN PABLO TORRES; JUÃ?REZ JORGE ANCHEYTA; MARTÃ?NEZ FERNANDO ALONSO; VÃ?ZQUEZ LAURA OLIVIA ALEMÃ?N
权利人:MEXICANO INST PETROL
摘要:This disclosure refers to a method for the synthesis of polymers with weight average molecular weights greater than 50,000 g/mol, chemically inert, with a minimum decomposition temperature of 425° C., and a main chain composed only of carbon-carbon bonds, which contain structures of the type of naphthalene, phenanthrene, anthracene, pyrene, carbazole or any other where two or more aromatic rings of six carbon atoms of the benzene-type are fused, which may or may not contain aromatic heterocycles. In addition, the polymers obtained from the present disclosure may or may not contain fluorine atoms in their structure. The synthesis described here is carried out by means of polycondensation between a polycyclic aromatic compound and a compound with a carbonyl group in its structure in a strong acid medium.

专利号:US-6995289-B2
优先权日:2000-08-02
标题 :Process for synthesis of alpha, beta-unsaturated ketones
发明人：PATEL IAN; HOPES PHILIP
权利人:ASTRAZENECA AB
摘要:A method for the synthesis of an α,β-unsaturated ketone useful for making substituted 1,4-dihydropyridines is described by reacting an aldehyde with pyrrolidine and then adding a ketone followed by trifluoroacetic acid at low temperature. The synthesis is used in a process for making substituted 1,4-dihydropyridines wherein a vinylogous amide is prepared by reacting a 1,3-cyclohexanedione with a phenylethylamine. The α,β-unsaturated ketone can be reacted with a vinylogous amide to form a 1,5-diketone which can be converted to a substituted 1,4-dihydropyridine.

专利号:US-7193103-B2
优先权日:2000-05-19
标题:Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester using oxazolidinone derivatives
发明人：PRAKASH INDRA
权利人:NUTRASWEET CO
摘要:Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester by treating N-(3,3-dimethylbutyl)-L-aspartic acid with ketones to give oxazolidinone derivatives, which are condensed with L-phenylalanine methyl ester.

专利号:US-5698741-A
优先权日:1995-05-25
标题 :Asymmetric synthesis of (-)6-chloro-4-cyclopropyl-ethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one
发明人：THOMPSON ANDREW S; CORLEY EDWARD G; GRABOWSKI EDWARD J J; YASUDA NOBUYOSHI
权利人:MERCK & CO INC
摘要:An improved synthesis of a highly potent HIV reverse transcription inhibitor is disclosed, involving an acetylide and a trifluoromethyl ketone which produces a chiral product in the presence of a chiral amino alcohol.

专利号:WO-2023083926-A1
优先权日:2021-11-12
标题 :Synthesis of (1r,2s,5s)-n-((s)-1-cyano-2-((s)-2-oxopyrrolidin-3-yl)ethyl)-3-((s)-3,3-dimethyl-2- (2,2,2-trifluoroacetamido)butanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
发明人：ZUPANCIC SILVO; RUZIC MILOS; SENICAR TANJA; BEZENSEK JURE
权利人:KRKA D D NOVO MESTO
摘要:The invention relates to a process for the synthesis of (1R,2S,5S)-N-((S)-1-cyano-2-((S)-2-oxopyrroli- din-3-yl)ethyl)-3-((S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl)-6,6-dimethyl-3-azabicy- clo[3.1.0]hexane-2-carboxamide.

专利号:WO-2022127640-A1
优先权日:2020-12-16
标题:Process for synthesis of furan-based diamines
发明人：GUO RUIJING; PIRES RAUL; BEUCK SASKIA; LATORRE MARTINEZ IRENE CRISTINA; PAN XIANGCHENG; JIANG YUAN
权利人:COVESTRO DEUTSCHLAND AG; GUO RUIJING
摘要:The invention provides a process for the synthesis of furan-based diamines based on renewable resources.