CAS: 52415-29-9; 6-Bromoindole

上下游产品

.7.)6-bromo-indole-2-carboxylic acid(Ref.7.) pyrrolidine 4-bromo-2-nitrotoluene N,N-dimethyl-formamide dimethyl acetalN,N-dimethyl-formamide dimethyl acetal .7.)6-bromo-tryptophan(Ref.7.) 6-indolyl phenyl ketone 6-methoxylindole 6-Bromogramine

4'-溴乙酰苯胺置于bis-Triphenylphosphine-Palladium(II) Chloride 盐酸,氢氧化钾,Copper(L) Iodide,硝酸,Sodium Ethanolate,三乙胺,Potassium Iodide,Tin(Ll) Chloride,Sodium Nitrite体系中,用 吡啶,乙醇 作为反应溶剂,化学反应 27.88H,反应生成 6-溴吲哚
参考文献:Sakamoto,Takao; Kondo,Yoshinori; Iwashita,Shigeki,Chemical And Pharmaceutical Bulletin,1987,Vol. 35,# 5,P. 1823-1828
标题:Sakamoto,Takao; Kondo,Yoshinori; Iwashita,Shigeki,Chemical And Pharmaceutical Bulletin,1987,Vol. 35,# 5,P. 1823-1828

专利信息

专利号:WO-2015131100-A1
优先权日:2014-02-28
标题:Ligand-controlled c(sp3)-h arylation and olefination in synthesis of unnatural chiral alpha amino acids
发明人：YU JIN-QUAN
权利人:SCRIPPS RESEARCH INST
摘要:The use of ligands to tune the reactivity and selectivity of transition metal-catalysts for C(-sp3)-H bond functionalization is a central challenge in synthetic organic chemistry. Herein, we report a rare example of catalyst-controlled C(sp3)-H arylation using pyridine and quinoline derivatives: the former promotes exclusive monoarylation, whereas the latter activates the catalyst further to achieve diarylation. Successive application of these ligands enables the sequential diarylation of a methyl group in an alanine derivative with two different aryl iodides, affording a wide range of β-Ar-p-Ar ' -cc-amino acids with excellent levels of diastereoselectivity (d.r. > 20:1). Both configurations of the β-chiral center can be accessed by choosing the order in which the aryl groups are installed. The use of a quinoline derivative as a ligand also enables C(sp3)-H olefination of a protected alanine.

专利号:US-10995078-B2
优先权日:2013-03-13
标 题:Compounds and compositions for inhibition of FASN
发明人：BAIR KENNETH W; LANCIA JR DAVID R; LI HONGBIN; LOCH JAMES; LU WEI; MARTIN MATTHEW W; MILLAN DAVID S; SCHILLER SHAWN E R; TEBBE MARK J
权利人:FORMA THERAPEUTICS INC
摘要:The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:

专利号:WO-2011050245-A1
优先权日:2009-10-23
标 题:Bicyclic heteroaryls as kinase inhibitors
发明人：FENG YANGBO; CHEN YEN TING; SESSIONS HAMPTON; MISHRA JITENDRA K; CHOWDHURY SARWAT; YIN YAN; LOGRASSO PHILIP; LUO JUN-LI; BANNISTER THOMAS; SCHROETER THOMAS
权利人:FENG YANGBO; CHEN YEN TING; SESSIONS HAMPTON; MISHRA JITENDRA K; CHOWDHURY SARWAT; YIN YAN; LOGRASSO PHILIP; LUO JUN-LI; BANNISTER THOMAS; SCHROETER THOMAS
摘要:The invention is directed to heteroaryl compounds useful as inhibitors of various kinase enzymes. In various embodiments, the invention provides a heteroaryl compound having inhibitory bioactivity with respect to a Rho kinase, an AKT kinase, a p70S6K kinase, a LIM kinase, an IKK kinase, a Flt kinase, an Aurora kinase, or a Src kinase, or any combination thereof. Compounds of the invention include bicyclic heteroaryl compounds of formula (I), which can contain a bridging nitrogen atom at a ring junction. The invention further provides methods of synthesis of compounds of the invention, pharmaceutical compositions, pharmaceutical combinations, and methods of treatment of malconditions using compounds of the invention.

专利号:WO-0053313-A2
优先权日:1999-03-09
标 题:Lanthanide catalysts for synthesis of compounds and combinatorial libraries

专利号:CN-113549661-B
优先权日:2020-04-26
标题:Method and application of biocatalytic synthesis of L-4-Cl-kynurenine or L-4-Br-kynurenine

专利号:CN-114539123-A
优先权日:2022-02-28
标 题 :A method for one-step synthesis of TMC-205