CAS: 612-12-4; 1,2-Bis(Chloromethyl)Benzene

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CAS号612-14-6 邻苯二甲醇 | CAS号95-47-6 邻二甲苯 | CAS号50-00-0 甲醛 | CAS号100-44-7 氯化苄 | CAS号108-88-3 甲苯 | CAS号131-11-3 邻苯二甲酸二甲酯； 避蚊酯 | CAS号88-95-9 邻苯二甲酰氯 | CAS号861338-62-7 bis-(2-ethoxyme... | CAS号128-09-6 N-氯代丁二酰亚胺 | CAS号7647-01-0 盐酸 | CAS号108683-62-1 2-(chloromethyl... | CAS号110762-24-8 (2S)-2-amino-3-... | CAS号1075-30-5 Bicyclo[4.2.0]o... | CAS号496-14-0 二氢异苯并呋喃 | CAS号612-14-6 邻苯二甲醇 | CAS号142066-41-9 [2-(chloromethy... | CAS号496-12-8 异吲哚啉 | CAS号143767-54-8 2-乙酰基-1,2,3,4-四... | CAS号17300-02-6 邻亚二甲苯二胺 | CAS号4385-35-7 3-异色酮

邻苯二甲酸二甲酯置于lithium Aluminium Tetrahydride,乙醚体系中,化学反应生成 邻二氯苄
参考文献:Intestinal Permeability In Adult Patients With Growth Hormone Deficiency
标题:Intestinal Permeability In Adult Patients With Growth Hormone Deficiency
摘要:Pathological Disruption Of The Intestinal Mucosa Increases The Paracellular Pathway,Leading To An Increase In The Penetration Of Large Molecules. Since Growth Hormone (Gh) Has A Trophic Intestinal Effect,We Used A Double Marker Test To Enable Examination Of Intestinal Permeability,Which Reflects The State Of Integrity Of The Intestinal Mucosa,We Recruited 22 Adult Patients,Mean Age 54+/-13.3 Years,With Gh Deficiency Due To Partial Or Total Hypopituitarism. None Had Received Gh Treatment At Any Time,Although They Were All In Optimized Replacement Therapy. A Control Group Was Composed Of 19 Healthy Age-Matched Relatives. The Intestinal Permeability Test Was Performed With Lactulose (5 G) And Mannitol (1 G) After An Oral Load Of 100 Mi Of Aqueous Solution. The Urinary Lactu-Lose/mannitol Ratio And The Percentages Of Lactulose And Mannitol Excreted Were Determined On A 5-H Urine Collection. There Were No Significant Differences Between The Patients And The Control Group In The Lactulose/mannitol Ratio (0.087+/-0.059 Vs 0.077+/-0.064,Respectively) Or In The Urinary Excretion Percentages Of Lactulose (0.067+/-0.048% Vs 0.073+/-0.070%,Respectively) Or Mannitol (5.127+/-3.269% Vs 5.068+/-2.985%,Respectively). In Conclusion,No Increase In Intestinal Permeability Was Detected In Patients With Gh Deficiency,So That In Spite Of The Known Trophic Effects Of Gh On The Epithelial Crypt Cells,There Was No Intestinal Hyperpermeability In These Patients. (C) 2001,Editrice Kurtis.
DOI:10.1007/bf03343817

专利信息

专利号:US-6479685-B2
优先权日:1998-01-09
标题 :Metallocene catalysts for synthesis of high-melting polyolefin copolymer elastomers
发明人：WAYMOUTH ROBERT M; KRAVCHENKO RAISA L; MACIEJEWSKI PETOFF JENNIFER; HUNG JOYCE
权利人:TRUSTEES OF THE LELAND STANDAR
摘要:Metallocene catalysts having plural coordination geometries for synthesis of high melting polyolefin copolymers suitable as thermoplastic elastomers. The inventive catalysts comprise unbridged, substituted or unsubstituted cyclopentadienyl metallocene catalysts that are capable of inter-converting between states with different polymerization or copolymerization characteristics, which interconversion is controlled by selecting the substituents of the cyclopentadienyl ligands so that the rate of interconversion of the two states is within several orders of magnitude of the rate of formation of a single polymer chain. Where r i >r f the polymer can be characterized as multiblock; where r i
专利号:US-7189864-B2
优先权日:1990-11-19
标 题:Method of preparing intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.

专利号:US-6022996-A
优先权日:1990-11-19
标 题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.

专利号:EP-0641333-B1
优先权日:1992-05-20
标 题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO; MONSANTO CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide compound of formula (I) from a chiral alpha amino aldehyde and halomethyllithium as an organometallic methylene-adding reagent. In formula (I) R<1> is selected from alkyl, aryl, cycloalkyl, cycloalkylalkyl and arylalkyl, which are optionally substituted with a group selected from alkyl, halogen, NO2, OR<9> or SR<9>, where R<9> represents hydrogen or alkyl; and P<1> and P<2> independently are selected from amine protecting groups, including but not limited to, arylalkyl, substituted arylalkyl, cycloalkenylalkyl and substituted cycloalkenylalkyl, allyl, substituted allyl, acyl, alkoxycarbonyl, aralkoxycarbonyl and silyl.

专利号:EP-0855388-B1
优先权日:1993-11-23
标 题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P; FRESKOS JOHN J; DECRESCENZO GARY A; BERTENSHAW DEBORAH E; HEINTZ ROBERT M; ZHANG SUHONG; LIU CHIN; LANEMAN SCOTT A
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a cyanohydrin from a chiral alpha amino aldehyde.

专利号:US-5665827-A
优先权日:1996-11-07
标 题:Synthesis of multiblock polymers using group IIA and IIB metal cyclic organometallic initiators
发明人：HALL JAMES E
权利人:BRIDGESTONE CORP
摘要:The invention is a practical process for anionically synthesizing multiblock polymers containing a plurality of blocks formed from polar and/or non-polar monomers by using a cyclic organometallic compound initiator that comprises a divalent metal atom and an organic moiety contained in a ring, preferably a cycloorganomagnesium initiator. Activation of the ring metallic atom results in anionic polymerization of the monomers by addition into the initiator ring at the bonds between the metallic atom and its two adjacent carbon atoms, the metallic atom acting as a bridge between the two living ends of the propagating chain. The active chain ends can be coupled or terminated.