CAS: 61281-37-6; Schisandrin B

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CAS号5780-07-4 肉豆蔻醛 | CAS号76763-88-7 (R)-dihydro-4-(...

Gomisin N置于chiralcel Od Column体系中,用 正己烷,异丙醇 作为反应溶剂,以7.8 Mg的收率获得产物戈米辛 N
参考文献:Identification Of Key Structural Characteristics Of Schisandra Chinensis Lignans Involved In P-Glycoprotein Inhibition
标题:Identification Of Key Structural Characteristics Of Schisandra Chinensis Lignans Involved In P-Glycoprotein Inhibition
摘要:The Aim Of The Present Study Was To Determine The Structural Requirements For Dibenzocyclooctadiene Lignans Essential For P-Glycoprotein Inhibition. Altogether 15 Structurally Related Lignans Isolated From Schisandra Chinensis Or Prepared By Modification Of Their Backbone Were Investigated,Including Three Pairs Of Enantiomers. P-Glycoprotein Inhibition Was Quantified Using A Doxorubicin Accumulation Assay In Human Promyelotic Leukemia Hl60/mdr Cells Overexpressing P-Glycoprotein. A Preliminary Quantitative Structure-Activity Relationship Analysis Revealed Three Main Structural Features Involved In P-Glycoprotein Inhibition: A 1,2,3-Trimethoxy Moiety,A 6-Acyloxy Group,And The Absence Of A 7-Hydroxy Group. The Most Effective Inhibitors,(-)-Gomisin N (1) And (+)-Deoxyschizandrin [(+)-2],Were Selected For Further Evaluation Of Their Effects. Both These Lignans Restored The Cytotoxic Effect Of Doxorubicin In Hl60/mdr Cells And When Combined With A Subtoxic Concentration Of This Compound Increased The Proportion Of G2/m Cells Significantly,Which Is A Usual Response To Treatment With This Anticancer Drug.
DOI:10.1021/np500521V

专利信息

专利号:US-12201669-B2
优先权日:2021-03-11
标 题:Small molecule suppressors of APOE gene expression and cerebral vascular amyloid pathology
发明人：TSAI LI-HUEI; BLANCHARD JOEL
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:The present disclosure provides methods of inhibiting amyloid synthesis in a subject using small molecule inhibitors. The invention also includes methods of treating disease associated with amyloid synthesis, such as Alzheimer's disease. The small molecule inhibitors disclosed herein are compounds which are non-immunosuppressant cyclosporin including the pharmaceutically acceptable salts thereof.

专利号:US-2009163573-A1
优先权日:2007-12-21
标 题:Compositions and methods for enhancing protein accretion in skeletal muscle
发明人：HEUER MARVIN A; CLEMENT KEN; MOLINO MICHELE; MACDOUGALL JOSEPH
权利人:MULTI FORMULATIONS LTD
摘要:A nutritional composition comprising at least an effective amount of geranylgeranylacetone or derivative of geranygeranylacetone and an effective amount of glutamine or derivative of glutamine, wherein the ingredients act substantially simultaneously to increase protein synthesis and inhibit protein degradation in skeletal muscle, via enhanced expression of heat shock proteins in cells, particularly heat shock protein 72. A method of same is also provided.

专利号:WO-2009079740-A1
优先权日:2007-12-21
标题:Compositions and methods for enhancing hypertrophy in skeletal muscle
发明人：HEUER MARVIN A; CLEMENT KEN; MOLINO MICHELE
权利人:MULTI FORMULATIONS LTD; MACDOUGALL JOSEPH; HEUER MARVIN A; CLEMENT KEN; MOLINO MICHELE
摘要:A nutritional composition comprising at least an effective amount of geranylgeranylacetone or derivative of geranygeranylacetone and an effective amount of glutamine or derivative of glutamine, wherein the ingredients act substantially simultaneously to increase protein synthesis and inhibit protein degradation in skeletal muscle, via enhanced expression of heat shock proteins in cells, particularly heat shock protein 72. A method of same is also provided.