CAS: 72537-17-8; 3-Chloro-2-Fluoro-5-(Trifluoromethyl)Pyridine

相似化合物

71701-96-7 69045-84-7 69045-82-5

上下游产品

2-amino-3-chloro-5-(trifluoromethyl)pyridine 2,3-dichloro-5-trifluoromethylpyridine 2,3-dichloro-5-(trichloromethyl)pyridine 1-[4-((3-chloro-5-(trifluoromethyl)-2-pyridinyl)oxy)-2-hydroxyphenyl]ethanone 2-(4'-hydroxyphenoxy)-3-chloro-5-trifluoromethylpyridine 3-chloro-2-[4-(prop-2-enyloxy)phenoxy]-5-(trifluoromethyl)pyridine 4-[(3-chloro-5-(trifluoromethyl)-2-pyridinyl)oxy]-2-(hydroxymethyl)phenol

2,3-二氯-5-三氟甲基吡啶置于potassium Fluoride体系中,用 二甲基亚砜 作为反应溶剂,以93.6%的收率获得产物3-氯-2-氟-5-(三氟甲基)吡啶
参考文献:3-氯-5-三氟甲基吡啶类化合物及中间体的制备方法
标题:3-氯-5-三氟甲基吡啶类化合物及中间体的制备方法
摘要:本发明公开了一种3-氯-5-三氟甲基吡啶类化合物及中间体的制备方法.本发明的如式3所示的化合物的制备方法,其包括如下步骤:有机溶剂和水的混合溶剂中,相转移催化剂的作用下,将如式2所示的化合物与金属氰化物进行取代反应,制得如式3所示的化合物;进一步包括如下步骤:溶剂中,氟化试剂作用下,将如式1所示的化合物进行氟化反应,制得所述如式2所示的化合物;也可进一步包括如下步骤:在氯化氢和乙醇作用下,将如式3所示的化合物进行pinner反应,然后进行水解成酯反应,制得如式4所示的化合物.本发明的3-氯-5-三氟甲基吡啶类化合物的制备方法成本低,生产安全性高,操作简单,收率较高,更适于工业化生产.

专利信息

专利号:WO-2011092618-A1
优先权日:2010-01-28
标题 :Method for the preparation of fluazinam
发明人：PASTORIO ANDREA; MORA CLAUDIA
权利人:FINCHIMICA SRL; PASTORIO ANDREA; MORA CLAUDIA
摘要:A method for the synthesis of 3-chloro, N- (3-chloro-5- trifluoromethyl-2-pyridyl), α, α, α-trif luoro, 2,6-dinitro- p-toluidine (Fluazinam) comprises an amination reaction of a pyridine, to obtain 2-amino, 3-chloro, 5- trif luoromethylpyridine, the addition of a strong base to the 2-amino, 3-chloro, 5-trif luoromethylpyridine, and a formation reaction of Fluazinam by coupling of the 2- amino-3-chloro-5-trif luoromethylpyridine with the 2,4- dichloro, 3,5-dinitro, benzotrif luoride. The amination reaction is conducted with anhydrous ammonia in an organic solvent. Furthermore, the coupling reaction as above takes place directly in the solution of Pyridine 2 coming from the amination step.

专利号:US-7812161-B2
优先权日:2007-03-05
标 题 :Synthesis of GlyT-1 inhibitors
发明人：PFLEGER CHRISTOPHE; WALDMEIER PIUS; WANG SHAONING
权利人:HOFFMANN LA ROCHE
摘要:The present invention relates to a process for preparation of a compound of formula I n nwhereinn Het, R 1 , R 2 , R 3 , and n are as defined herein and pharmaceutically acceptable acid addition salts thereof, which comprises reacting a compound of formula 21 with a compound of formula 8 to obtain a compound of formula 11 and coupling the compound of formula 11 in the presence of a coupling reagent or the corresponding acid halogenide with a compound of formula 15 to obtain a compound of formula I.

专利号:WO-2008107334-A2
优先权日:2007-03-05
标题:Process for the synthesis of glyt-1 inhibitors

专利号:US-2008221327-A1
优先权日:2007-03-05
标题:Synthesis of glyt-1 inhibitors

专利号:EP-2131843-B1
优先权日:2007-03-05
标题 :Process for the synthesis of glyt-1 inhibitors

专利号:CN-110143916-B
优先权日:2019-05-12
标题 :Synthesis process of fluazinam