CAS: 7452-59-7; Octyl Carbonochloridate

上下游产品

phosgene °Ctanol bis(trichloromethyl) carbonate tetrachloromethaneN-benzyloxycarbonylglycylglycylglycylglycine 2-°Ctyloxycarbonyloxy-propionic acid methyl ester 2-°Ctyloxycarbonyloxy-propionic acid butyl ester carbonic acid-(2-nitro-phenyl ester)-°Ctyl ester

光气,辛醇置于吡啶体系中,用 四氢呋喃,甲苯 作为反应溶剂,化学反应 0.33H,反应生成 氯甲酸正辛酯
参考文献:深入了解10-去甲氧基-10-甲基氨基秋水仙碱的氨基甲酸酯和硫代氨基甲酸酯的抗癌潜力
标题:深入了解10-去甲氧基-10-甲基氨基秋水仙碱的氨基甲酸酯和硫代氨基甲酸酯的抗癌潜力
摘要:秋水仙碱显示出非常高的抗有丝分裂活性,因此,它被用作产生新的抗癌药的先导化合物.为了开发具有更有利药理学特性的新型有用药物,已设计,合成和表征了一系列双重修饰的秋水仙碱衍生物.这些新型的10-去甲氧基-10-甲基氨基秋水仙碱氨基甲酸酯或硫代氨基甲酸酯衍生物已针对四种人类癌细胞系进行了抗增殖活性测试.另外,使用分子对接研究已将其作用方式评估为秋水仙碱结合位点抑制剂.大多数测试化合物显示出更大的细胞毒性(ic 50(在低纳摩尔范围内),并且具有比标准化学疗法(例如顺铂和阿霉素以及未修饰的秋水仙碱)更高的选择性指数.与秋水仙碱相比,它们在癌症治疗中的药理作用可能以较低的剂量实现,并导致较少的急性毒性问题.此外,我们提出了一种qsar模型,用于预测双修饰衍生物对两种肿瘤细胞系的抗增殖活性.
DOI:10.1016/j.Ejmech.2021.113282

专利信息

专利号:WO-0061545-A1
优先权日:1999-04-14
标题 :Methods for solid phase combinatorial synthesis of integrin inhibitors
发明人：GOPALSAMY ARIAMALA; YANG HUI YU
权利人:AMERICAN HOME PROD
摘要:Compounds of the formula (I) are useful in the treatment of various disorders including, but not limited to, cancer (tumor metathesis, tumorgenesis/tumor growth), angiogenesis (as in cancer, diabetic retinopathy, rheumatoid arthritis), restenosis (following balloon angioplasty or stent implantation), inflammation (as in rheumatoid arthritis, psoriasis), bone diseases (osteopenia induced by bone metastases, immobilization and glucocortocoid treatment, periodontal disease, hyperparathyroidism and rheumatoid arthritis), and as antiviral agents. Novel method of making compounds of formula (I) are also provided.

专利号:US-6586187-B1
优先权日:1999-04-14
标题:Methods for solid phase combinatorial synthesis of integrin inhibitors
发明人：GOPALSAMY ARIAMALA; YANG HUI Y
权利人:WYETH CORP
摘要:Compounds of the formulaare useful in the treatment of various disorders including, but not limited to, cancer (tumor metathesis, tumorgenesis/tumor growth), angiogenesis (as in cancer, diabetic retinopathy, rheumatoid arthritis), restenosis (following balloon angioplasty or stent implantation), inflammation (as in rheumatoid arthritis, psoriasis), bone diseases (osteopenia induced by bone metastases, immobilization and glucocortocoid treatment, periodontal disease, hyperparathyroidism and rheumatoid arthritis), and as antiviral agents. Novel method of making compounds of formula I are also provided.

专利号:US-7064122-B2
优先权日:2001-12-20
标题:Pancreatic lipase inhibitor compounds, their synthesis and use
发明人：WITTER DAVID; CASTELHANO ARLINDO
权利人:OSI PHARM INC
摘要:The subject invention features compounds having the structure: n n nwherein X is O, S, CH 2 or NR 5 ; Y is O or S; R 1 is H, substituted or unsubstituted C 1 -C 15 alkyl, C 1 -C 8 alkylaryl, —C(O)OR 4 , —C(O)NR 4 R 5 , —CR 6 R 6′ OR 4 , —CR 6 R 6′ OC(O)R 4 , —CR 6 R 6′ OC(O)NHR 7 , —C(O)NR 10 R 11 , —C(O)NR 8 R 9 NR 8 R 9 , —N(R 5 )C(O)NHR 5 , or CH 2 R 4 ; R 2 is a substituted or unsubstituted, straight chain C 1 —C 30 alkyl or branched C 3 -C 30 alkyl, aryl, alkylaryl, arylalkyl, heteroarylalkyl or cycloalkyl; R 3 is H or substituted or unsubstituted C 1 -C 6 alkyl or C 3 -C 10 cycloalkyl; R 4 is H or a substituted or unsubstituted, straight chain or branched, C 6 -C 30 alkyl, aryl, —CH 2 -aryl, aryl —C 1 -C 15 alkyl, heteroaryl-C 1 -C 15 alkyl or C 3 -C 10 cycloalkyl; R 5 is H or a substituted or unsubstituted, straight chain or branched, C 6 -C 30 alkyl, aryl C 1 -C 30 alkyl, heteroarylalkyl or cycloalkyl; R 6 and R 6′ are each independently H, substituted or unsubstituted C 1 -C 6 alkyl, dialkyl or C 3 -C 10 cycloalkyl or together form a 3-7 membered ring system; R 7 is H or substituted or unsubstituted C 1 -C 12 alkyl or C 3 -C 10 cycloalkyl; R 8 and R 9 are each independently H, substituted or unsubstituted C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 alkylaryl, or NR 8 R 9 together form a substituted piperazine or piperidine ring or a dihydro-1H-isoquinoline ring system, or a specific enantiomer thereof, or a specific tautomer, or a pharmaceutically acceptable salt thereof and a method for treating diabetes or obesity by administering a therapeutically effective amount of the compounds of the invention.

专利号:CN-217042496-U
优先权日:2022-04-14
标 题 :A kind of synthesis system of octyl thio chloroformate

专利号:JP-H0399052-A
优先权日:1989-08-25
标题 :Synthesis method of alkylsulfophenyl carbonate

专利号:CN-119504882-A
优先权日:2023-08-24
标题 :Synthesis method of GalNAc derivative