CAS: 79397-50-5; H-Dl-Pro-Ome.Hcl

相似化合物

145681-01-2 5211-23-4 52183-82-1

上下游产品

methanol rac-Pro-OH N-tert-butoxycarbonyl-proline L-prolineL-prolineoxazine(3R,8aS)-3-phenyl-3-(2-propenyl)-1,4-dioxo-3,4,6,7,8,8a-hexahydro-1H-pyrrolo2,1-c1,4oxazine prolinatemethyl (2S,1'S)-N-(1-hydroxy-1-phenyl-3-butenyl)-formylprolinate -(R,S)-Pro-OMeN-(R)-2-Methoxy-2-(trifluoromethyl)phenylacetyl-(R,S)-Pro-OMe 1-[2-(4-Chloro-phenoxy)-acetyl]-pyrrolidine-2-carboxylic acid methyl ester

专利信息

专利号:US-5654343-A
优先权日:1993-10-13
标 题:Method of treating a nitric oxide-associated disease with phenanthrene derivatives
发明人：MORITOKI HIDEKI; TAKAISHI YOSHIHISA; ADACHI MASAKAZU; ONO YUKIHISA
权利人:OTSUKA PHARMA CO LTD
摘要:PCT No. PCT/JP94/01695 Sec. 371 Date Jun. 6, 1995 Sec. 102(e) Date Jun. 6, 1995 PCT Filed Oct. 11, 1994 PCT Pub. No. WO95/10266 PCT Pub. Date Apr. 20, 1995This invention provides a nitric oxide synthesis inhibitor composition comprising, as an active ingredient, at least one member of the group consisting of various phenanthrene derivatives, typically represented by the following general formula (1), and salts thereof. (1) The nitric oxide synthesis inhibitor composition of this invention is useful for the prophylaxis and therapy of nitric oxide-associated diseases such as endotoxin shock.

专利号:WO-0010565-A1
优先权日:1998-08-18
标 题 :Growth hormone secretagogues
发明人：DODGE JEFFREY ALAN; HAUSER KENNETH LEE; HEIMAN MARK LOUIS; JONES SCOTT ALAN; ALT CHARLES ARTHUR; BRYANT HENRY UHLMAN; COHEN JEFFREY DANIEL; COPP JAMES DENSMORE; FAHEY KENNAN JOSEPH; GRITTON WILLIAM HARLAN; JUNGHEIM LOUIS NICKOLAUS; KENNEDY JOSEPH HENRY; LUGAR CHARLES WILLIS III; MUEHL BRIAN STEPHEN; PALKOWITZ ALAN DAVID; RATZ ANDREW MICHAEL; RHODES GARY ANTHONY; ROBEY ROBERT LEWIS; SEYLER DAVID EDWARD; SHEPHERD TIMOTHY ALAN; THRASHER KENNETH JEFF; TRANKLE WILLIAM GEORGE
权利人:LILLY CO ELI; DODGE JEFFREY ALAN; HAUSER KENNETH LEE; HEIMAN MARK LOUIS; JONES SCOTT ALAN; ALT CHARLES ARTHUR; BRYANT HENRY UHLMAN; COHEN JEFFREY DANIEL; COPP JAMES DENSMORE; FAHEY KENNAN JOSEPH; GRITTON WILLIAM HARLAN; JUNGHEIM LOUIS NICKOLAUS; KENNEDY JOSEPH HENRY; LUGAR CHARLES WILLIS III; MUEHL BRIAN STEPHEN; PALKOWITZ ALAN DAVID; RATZ ANDREW MICHAEL; RHODES GARY ANTHONY; ROBEY ROBERT LEWIS; SEYLER DAVID EDWARD; SHEPHERD TIMOTHY ALAN; THRASHER KENNETH JEFF; TRANKLE WILLIAM GEORGE
摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

专利号:US-4743616-A
优先权日:1984-07-31
标题 :Novel biologically active compound having anti-prolyl endopeptidase activity
发明人：TANAKA TAKAHARU; HIGUCHI NAOKI; SAITOH MASAYUKI; HASHIMOTO MASAKI
权利人:SUNTORY LTD
摘要:A novel compound that exhibits inhibitory activity against prolyl endopeptidase and a method for chemical synthesis of said compound, as well as its use as a prolyl endopeptidase inhibitor and an anti-amnesic agent that contains said compound as the active ingredient are provided.

专利号:US-3948971-A
优先权日:1972-05-03
标题 :N-protected-α-amino acid compounds
发明人：VEBER DANIEL F; BRADY STEPHEN F
权利人:MERCK & CO INC
摘要:Novel N-protected-α-amino acid compounds are disclosed in which the amino functionality is protected by a 1-methylcyclobutyloxycarbonyl or 1-methylcyclohexyloxycarbonyl. Processes for the synthesis of amino acids containing these protecting groups and the use of these novel amino acid compounds in the preparation of peptides are also disclosed.

专利号:WO-0144179-A1
优先权日:1999-12-17
标题 :Novel succinate compounds, compositions and methods of use and preparation
发明人：JAIN RAKESH; NI ZHI-JIE; PATEL DINESH V; YUAN ZHENGYU
权利人:VERSICOR INC; JACOBS JEFFREY W; JAIN RAKESH; NI ZHI JIE; PATEL DINESH V; YUAN ZHENGYU
摘要:Novel hydroxamic acid compounds of Formula (I) are disclosed. These hydroxamates inhibit peptide deformylase (PDF), an enzyme present in prokaryotes. The hydroxymates are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as matrix metalloproteinases (MMPs). Methods of synthesis and of use of the compounds are also disclosed.

专利号:US-6992097-B2
优先权日:1998-08-18
标 题 :Growth hormone secretagogues
发明人：HAUSER KENNETH LEE; DODGE JEFFREY ALAN; HEIMAN MARK LOUIS; JONES SCOTT ALAN; ALT CHARLES ARTHUR; BRYANT HENRY UHLMAN; COHEN JEFFREY DANIEL; COPP JAMES DENSMORE; FAHEY KENNAN JOSEPH; GRITTON WILLIAM HARLAN; JUNGHEIM LOUIS NICKOLAUS; KENNEDY JOSEPH HENRY; LUGAR III CHARLES WILLIS; MUEHL BRIAN STEPHEN; PALKOWITZ ALAN DAVID; RATZ ANDREW MICHAEL; RHODES GARY ANTHONY; ROBEY ROGER LEWIS; SEYLER DAVID EDWARD; SHEPHERD TIMOTHY ALAN; THRASHER KENNETH JEFF; TRANKLE WILLIAM GEORGE
权利人:LILLY CO ELI
摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.