CAS: 85909-08-6; Tert-Butyl 2-Oxopyrrolidine-1-Carboxylate

该化合物是一种多用途的N-Boc-保护性长效磷,广泛用作有机合成和制药研究的中间体,其主要优点包括在标准条件下高度稳定,便利处理和储存,以及作为丙烯酮衍生物的前体的作用.乙型-丁基氧碳基(Boc)保护组在多步反应中增强选择性,在温酸条件下能够有效减少保护.该化合物在浸泡和环流合成中特别有用,提供与广泛各种试剂的兼容性.其定义明确的再活动特征使它成为在医药化学和材料科学应用中建造复杂分子结构的可靠建筑块.

英文名称Tert-Butyl 2-Oxopyrrolidine-1-Carboxylate
中文名称1-(叔丁氧基羰基)-2-吡咯烷酮
IUPAC名称tert-butyl 2-oxopyrrolidine-1-carboxylate
其它别名1-(Tert-Butoxycarbonyl)-2-Oxopyrrolidine; 1-(Tert-Butoxycarbonyl)-2-Pyrrolidinone; N-Boc-Pyrrolidone; Tert-Butyl Oxopyrrolidine-1-Carboxylate; Pyrrolidin-2-One, N-Boc Prote
CAS编号85909-08-6
MFCD编号:MFCD00674099
EINECS号:617-776-7
FDA UNII编号:9GS4FVG7EW
分子式:C9H15NO3
分子量:185.22
产品CID: 1858526
产品分类首页→产品中心

相似结构搜索
InChIKey: GJJYYMXBCYYXPQ-UHFFFAOYSA-N
InChI=1S/C9H15NO3/c1-9(2,3)13-8(12)10-6-4-5-7(10)11/h4-6H2,1-3H3…
计算化学: 氢键受体数3.0氢键供体数0.0可旋转键数2.0

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
严重眼刺激类别2A
警示词Warning(警告)
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P271-P280-P302+P352-P305+P351+P338
UN编号NONH for all modes of transport
危险品标志Xi
安全声明26-36
危险类别码36/37/38
WGK Germany3

欧盟法规

REACH注册ECHA物质C&L通报REACH预注册

上下游产品

合成工艺路线路线简述

24424-99-5 = 85909-08-6
反应条件:1.1 Catalysts: Sodium Methoxide,(T-4)-Methoxy[2-[(Methylamino-Kn)Methyl]Phenyl-Kc][2-[(Methylamino)Methyl]Phenyl...; 12 H,70 °C
标题:Double Molecular Recognition With Aminoorganoboron Complexes: Selective Alcoholysis Of β-Dicarbonyl Derivatives
作者:Oishi,Shunsuke; Et Al
参考文献:Angewandte Chemie 日期:2012 卷标:51(22) 页码:5395-5399]

24424-99-5 = 85909-08-6
反应条件:1.1 Catalysts: 4-(Dimethylamino)Pyridine; 16 H,25 - 27 °C
标题:An Efficient Synthesis Of An αvβ3 Antagonist
作者:Yasuda,Nobuyoshi; Et Al
参考文献:Journal Of Organic Chemistry 日期:2004 卷标:69(6) 页码:1959-1966]

57294-38-9 = 85909-08-6
反应条件:1.1 Reagents: Oxalyl Chloride,Pyridine Solvents: Dichloromethane; 4 H,Rt
标题:Syntheses Of Phosphonic Esters Of Alendronate,Pamidronate And Neridronate
作者:Guenin,Erwann; Et Al
参考文献:European Journal Of Organic Chemistry 日期:2007 卷标:(20) 页码:3380-3391]

202925-92-6 = 85909-08-6
反应条件:1.1 Reagents: Sodium Periodate Solvents: Carbon Tetrachloride,Acetonitrile,Water; 10 Min,Rt1.2 Catalysts: Ruthenium Trichloride; 16 H,Rt
标题:A Facile Approach To Trans-4,5-Pyrrolidine Lactam And Application In The Synthesis Of Nemonapride And Streptopyrrolidine
作者:Huang,Wei; Et Al
参考文献:Tetrahedron 日期:2011 卷标:67(40) 页码:7829-7837]

86953-79-9 = 85909-08-6
反应条件:1.1 Reagents: Tert-Butyl Hydroperoxide,Iodobenzene Diacetate Solvents: Nitromethane,Decane; 30 Min,0 °C; 18 H,0 °C1.2 Reagents: Sodium Sulfite
标题:Oxidative Transformation Of Cyclic Ethers/amines To Lactones/lactams Using A Dib/tbhp Protocol
作者:Zhao,Yi; Et Al
参考文献:Rsc Advances 日期:2013 卷标:3(43) 页码:19765-19768]

86953-79-9 = 85909-08-6
反应条件:1.1 Reagents: Hydrochloric Acid,Oxygen Catalysts: 1-Butanaminium,N,N,N-Tributyl-,Eicosa-μ-Oxodi-μ5-Oxodecaoxodecatungstate(4-) (... Solvents: Acetonitrile,Dichloromethane,Water; 45 Min,Rt
标题:Selective C(Sp3)-H Aerobic Oxidation Enabled By Decatungstate Photocatalysis In Flow
作者:Laudadio,Gabriele; Et Al
参考文献:Angewandte Chemie 日期:2018 卷标:57(15) 页码:4078-4082]

75178-87-9 = 85909-08-6
反应条件:1.1 Reagents: Oxygen Catalysts: 2,6-Dimethoxy-1,4-Benzoquinone,(Tb-5-22)-[[2,2′-[(Methylimino-Kn)Bis[3,1-Propanediyl(Nitrilo-Kn)Methylidyne]]Bi...,Tetracarbonyl-μ-Hydro[(1,2,3,4,5-η)-1-Hydroxylato-2,3,4,5-Tetraphenyl-2,4-Cyclop... Solvents: Toluene; 18 H,100 °C
标题:Biomimetic Aerobic Oxidation Of Amino Alcohols To Lactams
作者:Babu,Beneesh P.; Et Al
参考文献:Chemistry - A European Journal 日期:2012 卷标:18(37) 页码:11524-11527]

56-12-2 = 85909-08-6 [标题:Reaction Conditions
标题:Product Class 10: γ-Lactams And Larger Ring Lactams
作者:Smith,M. B.
参考文献:Science Of Synthesis 日期:2005 卷标:21 页码:647-711]

24424-99-5 = 85909-08-6
反应条件:1.1 Catalysts: 4-(Dimethylamino)Pyridine Solvents: Acetonitrile; 2 H,Rt
标题:Enantioselective Synthesis Of Martinelline Chiral Core And Its Diastereomer Using Asymmetric Tandem Michael-Aldol Reaction
作者:Yoshitomi,Yayoi; Et Al
参考文献:Tetrahedron 日期:2008 卷标:64(51) 页码:11568-11579]

86953-79-9 = 85909-08-6
反应条件:1.1 Reagents: Potassium Carbonate,Oxygen,1-[(1,1-Dimethylethyl)Dioxy]-1,2-Benziodoxol-3(1H)-One Solvents: Benzene
标题:Radical Oxidation Of Amides And Related Compounds With Hypervalent Tert-Butylperoxyiodanes: Synthesis Of Imides And Tert-Butylperoxyamide Acetals
作者:Ochiai,Masahito; Et Al
参考文献:Tetrahedron Letters 日期:1999 卷标:40(30) 页码:5541-5544]

15761-39-4 = 85909-08-6
反应条件:1.1 Reagents: Oxygen Catalysts: 2-Propanol,2-Methyl-,Cerium(4+) Salt Solvents: Toluene; 6 H,Rt
标题:Cerium(Iv) Carboxylate Photocatalyst For Catalytic Radical Formation From Carboxylic Acids: Decarboxylative Oxygenation Of Aliphatic Carboxylic Acids And Lactonization Of Aromatic Carboxylic Acids
作者:Shirase,Satoru; Et Al
参考文献:Journal Of The American Chemical Society 日期:2020 卷标:142(12) 页码:5668-5675]

15761-39-4 = 85909-08-6
反应条件:1.1 Reagents: Oxygen Catalysts: Manganese,Bis[4,4′-Bis(1,1-Dimethylethyl)-2,2′-Bipyridine-Kn1,Kn1′]Bis(1,1,1-Tr... Solvents: Acetonitrile,1,2-Dichloroethane; 12 H,1 Atm,45 °C
标题:Decarboxylative Oxygenation Of Carboxylic Acids With O2Via A Non-Heme Manganese Catalyst
作者:Guan,Renpeng; Et Al
参考文献:Green Chemistry 日期:2022 卷标:24(7) 页码:2946-2952]

247232-86-6 = 85909-08-6
反应条件:1.1 Reagents: Cupric Chloride,Oxygen Catalysts: Palladium Solvents: Acetonitrile,Water
标题:Palladium(Ii)-Mediated Oxidative Cyclization Of N-Acyl Aminoalkynes: A New Route To γ-Lactams
作者:Doan,Huynh Dong; Et Al
参考文献:Tetrahedron Letters 日期:1999 卷标:40(37) 页码:6765-6768]

24424-99-5 + 147-85-3 = 85909-08-6
反应条件:1.1 Reagents: Sodium Hydroxide Solvents: 1,4-Dioxane,Water; 20 Min,0 °C1.2 Rt1.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 12.1 Reagents: Oxygen Catalysts: Manganese,Bis[4,4′-Bis(1,1-Dimethylethyl)-2,2′-Bipyridine-Kn1,Kn1′]Bis(1,1,1-Tr... Solvents: Acetonitrile,1,2-Dichloroethane; 12 H,1 Atm,45 °C
标题:Decarboxylative Oxygenation Of Carboxylic Acids With O2Via A Non-Heme Manganese Catalyst
作者:Guan,Renpeng; Et Al
参考文献:Green Chemistry 日期:2022 卷标:24(7) 页码:2946-2952]

24424-99-5 + 56-12-2 = 85909-08-6
反应条件:1.1 -2.1 Reagents: Oxalyl Chloride,Pyridine Solvents: Dichloromethane; 4 H,Rt
标题:Syntheses Of Phosphonic Esters Of Alendronate,Pamidronate And Neridronate
作者:Guenin,Erwann; Et Al
参考文献:European Journal Of Organic Chemistry 日期:2007 卷标:(20) 页码:3380-3391

N-Boc-Gamma-氨基丁酸置于草酰氯体系中,用二氯甲烷作为反应溶剂,化学反应 4.0H,以97%的收率获得产物1-(叔丁氧羰基)-2-吡咯烷酮
参考文献:阿仑膦酸盐,帕米膦酸盐和奈立膦酸盐的膦酸酯的合成
标题:阿仑膦酸盐,帕米膦酸盐和奈立膦酸盐的膦酸酯的合成
摘要:研究了获得氨基双膦酸 (Nbps) Pamidronate,Alendronate 和 Neridronate 膦酸酯的几种合成途径.一般指导原则是将 N 保护的氨基酸作为邻苯二甲酰亚胺酯或酰氯活化.发现琥珀酰亚胺酯的反应性较低并很快被废弃.当从 Boc 或 Cbz 保护的氨基酸开始时,会形成 γ-内酰胺.邻苯二甲酰亚胺 N-保护基团允许以高产率获得这三种 Nbp 的烷基或芳基单酯,二酯(对称或非对称)和三酯.((C) Wiley-Vch Verlag Gmbh & Co. Kgaa,69451 Weinheim,Germany,2007).
DOI:10.1002/ejoc.200601067

海关参考信息

2905122000-异丙醇
2905143000-叔丁醇
2912110000-甲醛
2912120000-乙醛
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-9676783-B2
优先权日:2008-10-22
标题:Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds
发明人：HAAS JULIA; ANDREWS STEVEN W; JIANG YUTONG; ZHANG GAN
权利人:ARRAY BIOPHARMA INC
摘要:Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.

专利号:US-10906033-B2
优先权日:2016-03-28
标题 :Synthesis and application of chiral substituted polyvinylpyrrolidinones
发明人：HUA DUY H
权利人:UNIV KANSAS STATE
摘要:Chiral polyvinylpyrrolidinone (CSPVP), complexes of CSPVP with a core species, such as a metallic nanocluster catalyst, and enantioselective oxidation reactions utilizing such complexes are disclosed. The CSPVP complexes can be used in asymmetric oxidation of diols, enantioselective oxidation of alkenes, and carbon-carbon bond forming reactions, for example. The CSPVP can also be complexed with biomolecules such as proteins, DNA, and RNA, and used as nanocarriers for siRNA or dsRNA delivery.

专利号:WO-2022193806-A1
优先权日:2021-03-15
标题 :Method for asymmetric catalytic synthesis of nicotine

专利号:CN-114836490-A
优先权日:2022-04-29
标题:Application of an imine reductase in catalytic synthesis of chiral 2-arylpyrrolidines

专利号:US-6423845-B1
优先权日:1999-11-23
标题 :Process and intermediates to a tetrahydro-[1,8]- Naphthyridine
发明人：RIVERA NELO R; XIAO YI; YASUDA NOBUYOSHI
权利人:MERCK & CO INC
摘要:A novel process is provided for the preparation of 3-(5,6,7,8-tetrahydro-[1,8]-naphthyridin-2-yl)-propylamine which is useful in the synthesis of alphav integrin receptor antagonists. Also provided are useful intermediates obtained from the process.

其他信息查阅

南通嘉星泰生物科技有限公司

网址: http://www.jxtbio.com
企业联系电话：18795782766;13773776703👤
地址:江苏省如皋市石庄镇张扬园村十组42号

⚠️ 未注册 · 未认证企业

备注: 📌 数据来源说明：本展台内容基于各搜索引擎等公开数据整理，仅作展示用途。请用户自行辨别
✉️ 若企业需抹除展台内容或有异议，请通过页面底部联系方式告知我们，我们会尽快处理。

北京偶合科技有限公司

网址: http://www.ouhechem.com
企业联系电话：010-51280831(不占线);010-82967028👤
地址:北京市海淀区西三旗桥东上奥世纪2b-1328室

⚠️ 未注册 · 未认证企业

南京江恒医药化工有限公司

网址: http://www.serpharm.cn
电话: 13951936332 18305166317👤

⚠️ 未注册 · 未认证企业

备注: 📌 数据来源说明：本展台内容基于各搜索引擎等公开数据整理，仅作展示用途。请用户自行辨别 ✉️ 若企业需抹除展台内容或有异议，请通过页面底部联系方式告知我们，我们会尽快处理。

安徽德信佳生物医药有限公司

网址: http://www.jndxj.com
企业联系电话：0531-82375892/15562613975👤
地址:安徽省阜阳市太和县经济开发区和谐大道9号

⚠️ 未注册 · 未认证企业

上海祺研医药科技有限公司

网址: http://www.shqypharm.com
企业联系电话：15021941186;13818307224👤
地址:上海市新飞路1500弄3号

⚠️ 未注册 · 未认证企业

第 1 / 1 页

现货

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

实用工具

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献

摘要:Nolte, J. C.; Urlacher, V. B., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 3, 36.
摘要:Leipold, F.; Hussain, S.; France, S. P.; Turner, N. J., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 2, 359.
摘要:Pollegioni, L.; Molla, G., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 3, 244.
摘要:DiRocco, D. A.; Schultz, D. M., Science of Synthesis: Photocatalysis in Organic Synthesis, (2018) 1, 622.
摘要:Nicolai, S.; Waser, J., Science of Synthesis: Hypervalent Halogens in Organic Synthesis, (2025) .