CAS: 98995-40-5; 4-Isopropoxybenzene-1-Sulfonyl Chloride

上下游产品

CAS号825-90-1 4-羟基苯磺酸钠

Sodium P-Hydroxybenzenesulfonate置于氯化亚砜,N,N-二甲基甲酰胺,Sodium Hydroxide体系中,用 甲醇,二氯甲烷 作为反应溶剂,化学反应 52.0H,反应生成 4-异丙氧基苯磺酰氯
参考文献:Design And Bio-Evaluation Of Indole Derivatives As Potent Kv1.5 Inhibitors
标题:Design And Bio-Evaluation Of Indole Derivatives As Potent Kv1.5 Inhibitors
摘要:Atrial Fibrillation (Af) Is One Of The Common Arrhythmias That Threaten Human Health. Kv1.5 Potassium Channel Is Reported As An Efficacious And Safe Target For The Treatment Of Af. In This Paper,We Designed And Synthesized Three Series Of Compounds Through Modifying The Lead Compound Rh01617 That Was Screened Out By The Pharmacophore Model We Reported Earlier. All Of The Compounds Were Evaluated By The Whole-Patch Lamp Technology And Most Of Them Possessed Potent Inhibitory Activities Against Kv1.5. Compounds Iiii And Iiil Were Evaluated For The Target Selectivity As Well As The Pharmacodynamic Effects In An Isolated Rat Model. Due To The Promising Pharmacological Behavior,Compound Iiil Deserves Further Pharmacodynamic And Pharmacokinetic Evaluations. (C) 2013 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmc.2013.08.041

专利信息

专利号:EP-1836163-B1
优先权日:2004-12-23
标题 :Pyrrolidine derivatives for the treatment of a disease depending on the activity of renin
发明人：BREITENSTEIN WERNER; COTTENS SYLVAIN; EHRHARDT CLAUS; JACOBY EDGAR; LORTHIOIS EDWIGE LILIANE JEANNE; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; SELLNER HOLGER; SIMIC OLIVER
权利人:NOVARTIS AG
摘要:Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula I wherein the substituents are as described in the specification.

专利号:US-2008194629-A1
优先权日:2005-05-03
标题 :3-Mono-and 3,5-Disubstituted Piperidine Derivatives as Renin Inhibitors
发明人：BAESCHLIN DANIEL KASPAR; BREITENSTEIN WERNER; EHRHARDT CLAUS; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; ZIMMERMANN JUERG; RUDISSER SIMON; VANGREVELINGHE ERIC; IRIE OSAMU; UMEMURA ICHIRO; SUZUKI MASAKI; MOGI MUNETO; KANAZAWA TAKANORI; YOKOKAWA FUMIAKI; NIHONYANAGI ATSUKO
权利人:BAESCHLIN DANIEL KASPAR; BREITENSTEIN WERNER; EHRHARDT CLAUS; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; ZIMMERMANN JUERG; RUDISSER SIMON; VANGREVELINGHE ERIC; IRIE OSAMU; UMEMURA ICHIRO; SUZUKI MASAKI; MOGI MUNETO; KANAZAWA TAKANORI; YOKOKAWA FUMIAKI; NIHONYANAGI ATSUKO
摘要:The invention relates to 3,5-piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,5-piperidine compound, and/or a method of treatment comprising administering a 3,5-piperidine compound, a method for the manufacture of a 3,5-piperidine compound, and novel intermediates and partial steps for their synthesis. Especially, the 3,5-piperidine compounds have the formula I, wherein the symbols have the meanings described in the specification.

专利号:WO-2010039911-A1
优先权日:2008-10-01
标题 :Calcilytic compounds
发明人：JEONG JAE U; MARQUIS ROBERT W JR
权利人:GLAXOSMITHKLINE LLC; JEONG JAE U; MARQUIS ROBERT W JR
摘要:Novel calcilytic compounds, pharmaceutical compositions, methods of synthesis and methods of using them are provided.