CAS: 1378387-81-5; 1-(7-Bromo-9,9-Difluoro-9H-Fluoren-2-yl)-2-Chloroethanone

上下游产品

2-bromo-9H-fluorene 2-bromo-7-iodofluorene 2-chloro-N-methoxy-N-methylacetamide 2-bromofluoren-9-one (S)-6-(2-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-2-oxoethyl) 5-tert-butyl 5-azaspiro[2.4]heptane-5,6-dicarboxylate 3-[6-(9,9-difluoro-7-{2-[5-(2-methoxycarbonylamino-3-methyl-butyryl)-5-aza-spiro[2.4]hept-6-yl]-3H-imidazol-4-yl}-9H-fluoren-2-yl)-1H-benzoimidazol-2-yl]-2-aza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester 5-aza-spiro[2.4]heptane-5,6-dicarboxylic acid 5-benzyl ester 6-[2-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-2-oxo-ethyl] ester 6-[5-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-aza-spiro[2.4]heptane-5-carboxylic acid benzyl ester

4'-溴乙酰苯胺置于盐酸,Aluminum (III) Chloride,N-氟代双苯磺酰胺,Lithium Hexamethyldisilazane,Sodium Nitrite体系中,用 四氢呋喃,甲醇,正己烷,水,乙酸乙酯 用作溶剂,化学反应 21.5H,反应生成7-溴-2-(氯乙酰基)-9,9-二氟芴
参考文献:一种雷迪帕韦关键中间体的制备方法
标题:一种雷迪帕韦关键中间体的制备方法
摘要:本发明提供了一种雷迪帕韦关键中间体7‑溴‑2‑(氯乙酰基)‑9,9‑二氟芴的制备方法.本发明以4‑溴苯胺为起始原料,经氨基乙酰化,与苄氯付克烷基化,在浓盐酸中脱乙酰基,在铜催化下重氮化偶联得2‑溴芴,然后将2‑溴芴与氟试剂反应制得7‑溴‑9,9‑二氟芴,最后与氯乙酰氯经付克酰基化反应得到中间体7‑溴‑2‑(氯乙酰基)‑9,9‑二氟芴.本发明的合成路线短,工艺安全,操作简单方便,原料成本低,满足了工业生产需求.

专利信息

专利号:US-9718807-B2
优先权日:2012-06-05
标 题 :Synthesis of antiviral compound
发明人：SCOTT ROBERT WILLIAM; VITALE JUSTIN PHILIP; MATTHEWS KENNETH STANLEY; TERESK MARTIN GERALD; FORMELLA ALEXANDRA; EVANS JARED WAYNE
权利人:GILEAD PHARMASSET LLC
摘要:The present disclosure provides processes for the preparation of a compound of formula I: n nwhich is useful as an antiviral agent. The disclosure also provides compounds that are synthetic intermediates to compounds of formula I.

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优先权日:2012-06-05
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优先权日:2012-06-05
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优先权日:2012-06-05
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专利号:US-2016340345-A1
优先权日:2012-06-05
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专利号:EP-2855454-B1
优先权日:2012-06-05
标 题 :Synthesis of antiviral compound