CAS: 16133-25-8; Pyridine-3-Sulfonyl Chloride

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16133-25-8 478264-00-5 166337-57-1

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CAS号636-73-7 3-吡啶磺酸 | CAS号626-55-1 3-溴吡啶 | CAS号16133-26-9 吡啶-3-硫醇 | CAS号42899-76-3 吡啶-3-磺酰氯盐酸盐 | CAS号110-91-8 吗啉 | CAS号10026-13-8 五氯化磷 | CAS号462-08-8 3-氨基吡啶 | CAS号110-86-1 吡啶 | CAS号4810-40-6 N-乙基砒啶-3-磺酰胺 | CAS号142141-07-9 异噻唑并[5,4-c]吡啶-3... | CAS号63636-89-5 吡啶-2-磺酰胺 | CAS号62009-33-0 5-溴砒啶-3-磺酰胺 | CAS号26103-51-5 3-(吡咯啉-1-基磺酰)砒啶 | CAS号26103-48-0 4-(吡啶-3-基磺酰基)吗啉 | CAS号2922-45-4 吡啶-3-磺酰胺 | CAS号26103-49-1 3-(哌啶-1-基磺酰)砒啶 | CAS号737799-50-7 (R)-5,5-二甲基-3-(... | CAS号88184-87-6 phenyl-(3-piper...

3-吡啶磺酸置于五氯化磷,三氯氧磷体系中,化学反应生成吡啶-3-磺酰氯
参考文献:钯催化的 Pida 介导的氨基酸衍生物的 δ-C(Sp3)−h 乙酰氧基化:压倒性的竞争性分子内胺化
标题:钯催化的 Pida 介导的氨基酸衍生物的 δ-C(Sp3)−h 乙酰氧基化:压倒性的竞争性分子内胺化
摘要:通过使用钯催化和phi(Oac) 2 (Pida)作为末端氧化剂和乙酰氧基源,实现了氨基酸衍生物的选择性δ-C(Sp 3 )−h乙酰氧基化. N-So 2 Py 保护/导向基团在控制化学选择性(分子间 Co 对分子内 Cn 键形成)和区域选择性(有利于 δ-Ch 3而不是 γ-Ch 2活化)方面发挥着关键作用.
Doi:10.1002/anie.202209865

专利信息

专利号:US-8138272-B2
优先权日:2006-05-22
标 题:Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds
发明人：KONRADI ANDREI W; SMITH JENIFER L
权利人:KONRADI ANDREI W; SMITH JENIFER L; ELAN PHARM INC
摘要:This invention provides an improved synthesis of polymer conjugates of formula (I), n nof agricultural, therapeutic, and food additive compounds. In particular, a process is described for the preparation of conjugates by treating primary or secondary alcohol substituents of active compounds with polymeric nucleophiles using “Mitsunobuâ€? or related reaction conditions.

专利号:US-6943254-B2
优先权日:1997-03-07
标 题 :Synthesis of pyrazinyl pyridine-3-sulfonamide compounds
发明人：HOGAN PHILIP JOHN
权利人:ASTRAZENECA UK LTD
摘要:A process for the manufacture of: n n nwherein R is (1-4C)alkyl, carboxyl(1-4C)alkyl or 1,3,4-oxadiazol-2-yl comprises:n (a) reaction of the diazonium salt of 3-amino-2-chloropyridine with thionyl chloride in water and an electron transfer catalyst; (b) reaction with isobutyl-(3-methoxy-5-methylpyrazin-2-yl)carbamate and an alkali metal hydride in inert solvent; and (I) where R is (1-4C)alkyl, carboxy(1-4C)alkyl: (c) reaction with a boronic acid: n n (or an anhydride or ester therof) in the presence of a base and a palladium or nickel catalyst in solvent; and removal of the isobutoxy carbonyl group; or (ii) where R is 1,3,4-oxadiazol-2-yl (c) reaction with 4-methoxycarbonylphenylboronic acid (or an anhydride or ester thereof) with a source fluoride ion under aqueous conditions; (d) removal of the isobutoxycarbonyl protecting group; (e) conversion of the methyl ester group to the hydrazide; and (f) conversion to a 1,3,4-oxadiazol-2-yl moiety.

专利号:US-8697888-B2
优先权日:2012-01-06
标题 :Substituted (1-(methylsulfonyl)azetidin-3-yl)(heterocycloalkyl)methanone analogs as antagonists of muscarinic acetylcholine M1 receptors
发明人：LINDSLEY CRAIG W; CONN P JEFFREY; WOOD MICHAEL R; MELANCON BRUCE J; CHEUNG YIU-YIN
权利人:UNIV VANDERBILT
摘要:In one aspect, the invention relates to substituted (1-(methylsulfonyl)azetidin-3-yl)(heterocycloalkyl)methanone analogs, derivatives thereof, and related compounds, which are useful as antagonists of the muscarinic acetylcholine receptor M 1 (mAChR M 1 ); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-5521179-A
优先权日:1991-04-18
标题 :Heterocyclic amides
发明人：BERNSTEIN PETER R; SHAW ANDREW; THOMAS ROYSTON M; WARNER PETER; WOLANIN DONALD J
权利人:ZENECA LTD
摘要:The present invention relates to certain novel heterocyclic amides which are 1-pyridylacetamide compounds of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these heterocyclic amides, processes for preparing the heterocyclic amides, pharmaceutical compositions containing such heterocyclic amides and methods for their use.

专利号:EP-0630382-B1
优先权日:1992-04-16
标题 :Lactam dipeptides having hle inhibiting activity
发明人：BERSTEIN PETER ROBERT; THOMAS ROYSTON MARTIN; WARNER PETER; WOLANIN DONALD JOHN
权利人:ZENECA LTD
摘要:The present invention relates to certain novel heterocyclic compounds which are 1-pyridylacetamide compounds of formula (I), set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these heterocyclic compounds, processes for preparing the heterocyclic compounds, pharmaceutical compositions containing such heterocyclic compounds and methods for their use.

专利号:UA-68408-C2
优先权日:1998-12-23
标 题:3-azabicyclo[3.1.0]hexane derivatives as opiate receptor ligands, pharmaceutical and veterinary composition, method for treatment and method for synthesis of derivatives