CAS: 23687-25-4; Isoquinolin-4-Amine

相似化合物

1315303-80-0 23707-37-1 1423031-91-7

上下游产品

4-bromoisoquinoline 4-azidoisoquinoline ethanethiol 4-nitro-isoquinoline 4-acetamidoisoquinoline N-(isoquinolin-4-yl)benzamide N-acetyl-sulfanilic acid-[4]isoquinolylamideN-acetyl-sulfanilic acid-[4]isoquinolylamide 5,6,7,8-tetrahydro-[4]isoquinolylamine

4-溴异喹啉置于(Cypf-T-Bu)Pdcl2 Lithium Amide体系中,用 乙二醇二甲醚 用作溶剂,化学反应 20.0H,以82%的收率获得4-氨基异喹啉
参考文献:氨和锂酰胺与芳基卤化物的钯催化偶联
标题:氨和锂酰胺与芳基卤化物的钯催化偶联
摘要:描述了芳基卤化物与氨或氨基锂的温和钯催化偶联,形成伯芳胺作为主要产物.这些反应以极好的选择性形成伯芳胺而不是二芳胺的形成(芳胺与二芳胺的比例为 9.5:1 至超过 50:1).此外,第一个带有末端-Nh2配体的有机钯配合物已经被分离出来.该配合物还原消除形成芳胺.
Doi:10.1021/ja064005T

专利信息

专利号:US-8058477-B2
优先权日:2006-03-21
标 题 :Process for the synthesis of arylamines from the reaction of an aromatic compound with ammonia or a metal amide
发明人：HARTWIG JOHN F; SHEN QILONG
权利人:HARTWIG JOHN F; SHEN QILONG; UNIV YALE
摘要:A catalytic process for the synthesis of aromatic primary amines, reagent compositions for effecting the process, and transition metal complexes useful in the process, are provided.

专利号:US-2008171873-A1
优先权日:2007-01-12
标题:Synthesis of selected stereoisomers of certain substituted alcohols
发明人：HARMS ARTHUR E
权利人:HARMS ARTHUR E
摘要:A process for producing one selected stereoisomer of a substituted alcohol comprises reacting a stereoisomeric amine with a halogen-substituted heterocyclic compound, or a stereoisomeric ketone or aldehyde with an amino-substituted heterocyclic compound. The process avoids the production of a racemic mixture of stereoisomers of the prior art. Such a stereoisomeric substituted alcohol can be used for anti-inflammatory therapy.

专利号:WO-2008088969-A2
优先权日:2007-01-12
标 题 :Synthesis of selected stereoisomers of certain substituted alcohols

专利号:US-2009234126-A1
优先权日:2006-03-21
标 题:Process for the Synthesis of Arylamines from the Reaction of an Aromatic Compound with Ammonia or a Metal Amide

专利号:JP-2009530403-A
优先权日:2006-03-21
标 题 :Synthesis of arylamines from reactions of aromatic compounds with ammonia or metal amides.

专利号:CA-2646978-A1
优先权日:2006-03-21
标 题:Process for the synthesis of arylamines from the reaction of an aromaticcompounds with ammonia or a metal amide