CAS: 25177-85-9; 2,3-Dihydro-1H-Indene-2-Carboxylic Acid

上下游产品

CAS号26453-01-0 2,3-二氢-1H-茚-2-甲腈 | CAS号66014-45-7 2,2-Bisethoxyca... | CAS号81290-34-8 ethyl indan-2-c... | CAS号2437-08-3 茚满-2,2-二羧酸 | CAS号141738-19-4 Spiro[1,3-dioxa... | CAS号91-13-4 α,α'-二溴邻二甲苯 | CAS号88-99-3 邻苯二甲酸 | CAS号105-53-3 丙二酸二乙酯 | CAS号55589-21-4 2-hydroxy-1,3-d... | CAS号496-11-7 茚满 | CAS号1006-27-5 earthy indane | CAS号39060-95-2 2-(2,3-dihydro-... | CAS号95-13-6 茚 | CAS号209225-00-3 2,3-二氢-4-硝基-1H-... | CAS号209225-01-4 (9ci)-2,3-二氢-5-... | CAS号5445-45-4 (2,3-二氢-1氢-茚-2-基)甲醇 | CAS号175079-50-2 (9ci)-2,3-二氢-1H... | CAS号37414-44-1 2,3-二氢-1h-茚-2-甲醛 | CAS号146737-65-7 茚烷-2-甲胺盐酸盐

2-Hydroxy-Indan-2-Carbonitrile置于盐酸,氢氧化钾,Pd-Baso4,乙醇,Phosphorus Pentoxide,苯体系中,化学反应生成2-茚羧酸
参考文献:Perold; V. Reiche,Journal Of The South African Chemical Institute,1957,Vol. 10,P. 5,10
标题:Perold; V. Reiche,Journal Of The South African Chemical Institute,1957,Vol. 10,P. 5,10

专利信息

专利号:WO-9717071-A1
优先权日:1995-11-08
标 题 :Stereoselective synthesis of endothelin receptor antagonists
发明人：MILLS ROBERT JOHN; KOWALSKI CONRAD JOHN; PING LI-JEN; GOMBATZ KERRY JOSEPH
权利人:SMITHKLINE BEECHAM CORP; MILLS ROBERT JOHN; KOWALSKI CONRAD JOHN; PING LI JEN; GOMBATZ KERRY JOSEPH
摘要:The present invention is directed to a synthetic route for preparing endothelium receptor antagonists of formulae (7B) and (7A) and to the chiral intermediates.

专利号:JP-2000507918-A
优先权日:1995-11-08
标 题:Stereoselective synthesis of endothelin receptor antagonists

专利号:EP-0915699-A1
优先权日:1995-11-08
标 题 :Stereoselective synthesis of endothelin receptor antagonists

专利号:EP-0915699-A4
优先权日:1995-11-08
标题:STEREPSELECTIVE SYNTHESIS OF ENDOTHELIN RECEPTOR ANTAGONISTS

专利号:US-7807709-B2
优先权日:2005-03-23
标题 :Organic compounds
发明人：EHRHARDT CLAUS; IRIE OSAMU; LORTHIOIS EDWIGE LILIANE; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; SELLNER HOLGER
权利人:NOVARTIS AG
摘要:The invention relates to the use of (3,4-di-, 3,3,4-tri, 3,4,4-tri- or 3,3,4,4-tetra-)substituted pyrrolidine compounds for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; compounds that are part of a subclass of these substituted pyrrolidine compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; new compounds that are part of a subclass of these substituted pyrrolidine compounds; pharmaceutical formulations comprising said substituted pyrrolidine compounds, and/or a method of treatment comprising administering said substituted pyrrolidine compounds, a method for the manufacture especially of said new substituted pyrrolidine compounds, as well as novel intermediates, starting materials and/or partial steps for their synthesis.

专利号:US-9695191-B2
优先权日:2009-08-05
标题 :Conformationally constrained, fully synthetic macrocyclic compounds
发明人：OBRECHT DANIEL; ERMERT PHILIPP; OUMOUCH SAID; LACH FRANCK; LUTHER ANATOL; MARX KARSTEN; MÖHLE KERSTIN
权利人:OBRECHT DANIEL; ERMERT PHILIPP; OUMOUCH SAID; LACH FRANCK; LUTHER ANATOL; MARX KARSTEN; MÖHLE KERSTIN; POLYPHOR AG
摘要:Conformationally restricted, spatially defined 12-30 membered macrocyclic ring systems of type (I) are constituted by three distinct building blocks: an aromatic template a, a conformation modulator b and a spacer moiety c as detailed in the description and the claims. Macrocycles of type (I) are readily manufactured by parallel synthesis or combinatorial chemistry. They are designed to interact with specific biological targets. In particular, they show agonistic or antagonistic activity on the motilin receptor (MR receptor), on the serotonin receptor of subtype 5-HT 2B (5-HT 2B receptor), and on the prostaglandin F2•receptor (FP receptor). They are thus potentially useful for the treatment of hypomotility disorders of the gastrointestinal tract such as diabetic gastroparesis and constipation type irritable bowl syndrome; of CNS related diseases like migraine, schizophrenia, psychosis or depression; of ocular hypertension such as associated with glaucoma and preterm labour.