CAS: 27258-33-9; 1-Methyl-1H-Pyrazole-5-Carbaldehyde

相似化合物

66121-72-0 16034-46-1 84547-61-5

上下游产品

1-methyl-1H-imidazole N,N-dimethyl-formamide 1-methyl-1H-pyrazole 4-(dimethylamino)-1,1-dimethoxy-but-3-en-2-one (1-methyl-1H-pyrazol-5-yl)methanol methyl 7-{4-[2-(butoxy)ethoxy]phenyl}-1-[(1-methyl-1H-pyrazol-5-yl)methyl]-2,3-dihydro-1H-1-benzazepine-4-carboxylate 4-{[(1-methyl-1H-pyrazol-5-yl)methyl]sulfanyl}aniline 7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(1-methyl-1H-pyrazol-5-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

5-(Dimethoxymethyl)-1-Methyl-1H-Pyrazole置于盐酸体系中,用 四氢呋喃,水 用作溶剂,化学反应 48.0H,以3.49 G的收率获得1-甲基-1H-吡唑-5-甲醛
参考文献: Pyrimidine Pde10 Inhibitors[fr] Inhibiteurs Pyrimidines De Pde10
标题: Pyrimidine Pde10 Inhibitors[fr] Inhibiteurs Pyrimidines De Pde10
摘要:本发明涉及嘧啶化合物,这些化合物用作治疗与磷酸二酯酶10(pde10)相关的中枢神经系统障碍的治疗剂.本发明还涉及使用这些化合物来治疗神经和精神障碍,如精神分裂症,精神疾病或亨廷顿病,以及与纹状体功能减退或基底神经节功能障碍相关的疾病.

专利信息

专利号:US-2016153015-A1
优先权日:2013-06-27
标 题 :Synthesis method for l-heterocyclic amino acid and pharmaceutical composition having thereof
发明人：HONG HAO; ZHENG CHANGSHENG; GUO LINA
权利人:ASYMCHEM LAB TIANJIN CO LTD; ASYMCHEM LIFE SCIENCE TIANJIN CO LTD; TIANJIN ASYMCHEM PHARMACEUTICAL CO LTD; ASYMCHEM LAB FUXIN CO LTD; JILIN ASYMCHEM LAB CO LTD
摘要:A synthesis method for an L-heterocyclic amino acid and a pharmaceutical composition having the said amino acid are provided in the present disclosure. The synthesis method comprises: step A: preparing a heterocyclic keto acid, wherein the heterocycle in the heterocyclic keto acid is selected from any one of a five-membered heterocycle, a six-membered heterocycle, a seven-membered heterocycle, an alkyl-substituted five-membered heterocycle, an alkyl-substituted six-membered heterocycle, and an alkyl-substituted seven-membered heterocycle, and the keto acid group in the heterocyclic keto acid has a structural formula of n n n n n n n n n n and is located on any one of the carbon positions of the heterocycle, and step B: mixing the heterocyclic keto acid with ammonium formate, a phenylalanine dehydrogenase, a formate dehydrogenase and a coenzyme NAD + , and carrying out a reductive amination reaction to generate L-heterocyclic amino acid, wherein the amino acid sequence of the phenylalanine dehydrogenase is SEQ ID No. 1.

专利号:US-11267820-B2
优先权日:2015-09-09
标 题 :Tricyclic fused pyridin-2-one derivatives and their use as BRD4 inhibitors
发明人：VADIVELU SARAVANAN; RAJAGOPAL SRIDHARAN; RAMAIAH MANJUNATHA M; GONDRALA PAVAN KUMAR; CHINNAPATTU MURUGAN; SIVANANDHAN DHANALAKSHMI; PARIKH PAYAL KIRAN; MULAKALA CHANDRIKA
权利人:JUBILANT BIOSYS LTD
摘要:The present disclosure describes heterocyclic compounds of Formula I or, its stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms and pharmaceutically active derivatives thereof and pharmaceutical compositions containing them as the active ingredient. The present disclosure also describes the synthesis and characterization of aforementioned compounds to exhibit high anticancer activity. The compounds of the present disclosure are useful as medicaments and their use in the manufacture of medicaments for treatment, prevention, or suppression of diseases, an conditions mediated b one or more BET family of bromodomains.

专利号:US-9957277-B2
优先权日:2015-11-25
标题 :eIF4A-inhibiting compounds and methods related thereto
发明人：ERNST JUSTIN T; REICH SIEGFRIED H; SPRENGELER PAUL A; TRAN CHINH VIET; PACKARD Garrick Kenneth; XIANG ALAN X; NILEWSKI CHRISTIAN; MICHELS THEO
权利人:EFFECTOR THERAPEUTICS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. n nFor Formula I compounds X, Y, R 1 , R 2 , R 3a , R 3b , R 4a , R 4b and R 5 are as defined in the specification. The inventive Formula I compounds are inhibitors of eIF4A and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.