CAS: 28868-76-0; Dimethyl 2-Chloromalonate

相似化合物

36437-19-1 14064-10-9 4755-81-1

上下游产品

CAS号108-59-8 丙二酸二甲酯 | CAS号563-79-1 2,3-二甲基-2-丁烯 | CAS号762-42-5 丁炔二酸二甲酯 | CAS号51419-59-1 4-甲基苄磺酰氯 | CAS号4025-71-2 2-苯基-乙烷磺酰氯 | CAS号344-14-9 2-氟丙二酸二甲酯 | CAS号1733-15-9 1,1,2,2-Ethenet... | CAS号29340-86-1 dimethyl 2,2-di... | CAS号63014-04-0 4-正丙基苯磺酸氯 | CAS号5464-22-2 四甲基乙烷-1,1,2,2-四羧酸酯 | CAS号29653-30-3 dimethyl 2,2-di...

2-Chlor-3,3-Dimethoxy-Acrylsaeure-Methylester置于水体系中,用 乙醚 用作溶剂,化学反应生成氯丙二酸二甲酯
参考文献:Hoffmann,R.W. Et Al.,Chemische Berichte,1972,Vol. 105,P. 2104-2110
标题:Hoffmann,R.W. Et Al.,Chemische Berichte,1972,Vol. 105,P. 2104-2110

专利信息

专利号:WO-2014080341-A1
优先权日:2012-11-21
标题 :New process for the synthesis of trichloropyrimidine-amine derivatives
发明人：Czibula László; Dobay László; SZAVICSKÓ KRISZTINA; KISS-BARTOS DOROTTYA; Nagyné Bagdy Judit
权利人:RICHTER GEDEON NYRT
摘要:The invention relates to a new process for the synthesis of 2-(N-methyl)-amino-4,5,6- trichloro-l,3-pyrimidine, which is more economical than the known process, as well as the new compounds synthesized as intermediates in the process: 2-(N',N'-dimethylamino- methylene)-amino-4,5,6-trichloro-l,3-pyrimidine and 2-(N-formyl)-amino-4,5,6-trichloro-l,3- pyrimidine.

专利号:US-5981748-A
优先权日:1995-06-07
标题:Synthesis of optically pure compounds useful as GARFT inhibitors and their intermediates
发明人：VARNEY MICHAEL D; ROMINES WILLIAM H; PALMER CYNTHIA L
权利人:AGOURON PHARMA
摘要:The invention relates to methods of making compounds of the formula VII ##STR1## and their enantiomers, where Ar is a substituted or unsubstituted five- or six-membered aromatic group and B is either an amino acid linked through the amino portion to form an amide or a C 1 -C 6 alcohol linked through the alcohol portion to form an ester. These compounds are advantageously employed as intermediates to prepare optically pure compounds that are active GARFT inhibitors. In one method, a compound of the formula ##STR2## is reacted with a compound of the formula ##STR3## where X is a halogen.

专利号:ES-2206580-T3
优先权日:1995-06-07
标题 :SYNTHESIS OF OPTICALLY PURE COMPOUNDS USEFUL AS INJERTS OF INJERTO AND ITS INTERMEDIARIES.

专利号:DE-69629703-T2
优先权日:1995-06-07
标题 :SYNTHESIS OF OPTICALLY PURE COMPOUNDS AS GARFT INHIBITORS AND THEIR INTERMEDIATE PRODUCTS

专利号:EP-2922824-A1
优先权日:2012-11-21
标题 :New process for the synthesis of trichloropyrimidine-amine derivatives

专利号:US-5723607-A
优先权日:1993-01-29
标题:Compounds useful as antiproliferative agents and GARFT inhibitors
发明人：VARNEY MICHAEL D; ROMINES WILLIAM H; PALMER CYNTHIA L
权利人:AGOURON PHARMACETICALS INC
摘要:The invention generally relates to compounds of the formula I, which are in equilibrium with their 4-hydroxy tautomers, and their pharmaceutically acceptable salts: where n is 0 to 2; A is S, CH2, O, NH or Se, and when n is 0, A is not CH2, and when n is 1, A is not CH2 or NH; X is a substituted or unsubstituted C1-C3 alkyl, C2-C3 alkenyl, C2-C3 alkynyl or amino, or sulfur or oxygen; Ar is a substituted or unsubstituted monocyclic carbocycle or heterocycle, or fused or nonfused polycyclic carbocycle or heterocycle; and R1 and R2 are hydrogen or a moiety that forms together with the attached CO2 a readily hydrolyzable ester group. These compounds and their salts are useful as inhibitors of GARFT or as antiproliferative agents. The invention also pertains to pharmaceutical compositions and methods employing such compounds as GARFT inhibitors or antiproliferative agents. The invention also relates to compounds useful as intermediates for preparing such compounds, and to their synthesis.