四氢糠醇置于t406石油添加剂,氯化亚砜体系中,用 二氯甲烷 用作溶剂,以91%的收率获得2-氯甲基四氢呋喃 参考文献:Thionyl Chloride-Benzotriazole In Methylene Chloride: A Convenient Solution For Conversion Of Alcohols And Carboxylic Acids Expeditiously Into Alkyl Chlorides And Acid Chlorides By Simple Titration 标题:Thionyl Chloride-Benzotriazole In Methylene Chloride: A Convenient Solution For Conversion Of Alcohols And Carboxylic Acids Expeditiously Into Alkyl Chlorides And Acid Chlorides By Simple Titration 摘要:在干燥的二氯甲烷中,以1:1等量混合的亚硫酰氯和苯并三唑溶液,在室温下能高效地将醇和羧酸分别转化为相应的烷基氯化物和酰氯,且通过简单的滴定法即可获得极佳的收率. Doi:10.1055/s-1999-2943
专利号:WO-2023286078-A1 优先权日:2021-07-13 标题:An improved process for the preparation of an intermediate of baloxavir morboxil 发明人:TALASANI SHYAM SUNDER REDDY; BUDIDETI SHANKAR REDDY; KOTTE RAJASHEKAR; SATTI VENKATA REDDY; MALA NAGENDRA; MUDDASANI PULLA REDDY; NANNAPANENI VENKAIAH CHOWDARY 权利人:NATCO PHARMA LTD 摘要:The present invention provides an improved process for the preparation of (12aR)-3,4,12,12a-tetrahydro-7-(phenylmethoxy)-1H-[1,4]oxazino[3,4-c] pyrido[2,1-f] [1,2,4]triazine-6,8-dione of Formula (I). Formula I which is a key intermediate in the synthesis of Baloxavir Morboxil of Formula (II).
专利号:US-4528195-A 优先权日:1978-02-01 标题:Imidazole derivatives and salts thereof, their synthesis and intermediates and pharmaceutical formulations 发明人:THOROGOOD PETER B 权利人:THOROGOOD PETER B 摘要:Pharmaceutical formulations comprising an imidazole (or pharmaceutically acceptable salt thereof) of formula: ##STR1## wherein (i) A is an aliphatic hydrocarbon residue of from 1 to 4 carbon atoms and R is a naphthyl, tetrahydronaphthyl, heterocyclyl, arylthio, arylalkylthio, aryloxy, arylalkyloxy, arylhydroxymethylene, arylcarbonyl, arylalkylcarbonyl, alkyloxy, alkylthio or a substituted cycloalkyl or cycloalkenyl group or n (ii) A is an --SO 2 -- group and R is aryl or heterocyclyl or n (iii) A is a chemical bond and R is a heterocyclyl or n Some of these imidazoles and salts are novel. n Methods of preparing the imidazoles are disclosed. The imidazoles and their salts are useful in the treatment or prophylaxis of thrombo-embolic conditions, shock and angina pectoris.
专利号:CN-116606208-A 优先权日:2023-05-30 标题:Synthesis method of active ingredient (Z)-9-dodecen-1-ol acetate of sex pheromone of Spodoptera frugiperda
专利号:CN-113666800-B 优先权日:2021-09-06 标 题:A kind of synthesis method of 4-pentyn-1-ol
摘要:Suginome, M.; Ohmura, T., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 171. 摘要:Summary Tables of Biological Tests, National Research Council Chemical-Biological Coordination Center., 4(319), 1952