CAS: 4497-04-5; 3-Morpholinopropanoic Acid

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CAS号33611-43-7 4-吗啉丙酸甲酯 | CAS号110-91-8 吗啉 | CAS号292638-85-8 丙烯酸甲酯 | CAS号57-57-8 丙内酯 | CAS号62131-51-5 phenyl 3-morpho...

4-吗啉丙酸甲酯置于potassium Hydroxide,盐酸体系中,用 水 作为反应溶剂,化学反应生成 3-(4-吗啉基)丙酸
参考文献:开发了一系列作为g-四链体配体的双三唑†
标题:开发了一系列作为g-四链体配体的双三唑†
摘要:端粒酶(一种保护染色体末端的特殊复合物)的维护是由端粒酶复合物提供的,端粒酶是80%以上的癌细胞激活但在大多数正常细胞中却不存在的关键因素.靶向端粒维持机制可能会阻止多种癌症类型的肿瘤生长.染色体的端粒末端由富含鸟嘌呤的dna的非编码重复序列组成.这些富含g的末端可以折叠成称为g-四链体的结构.通过称为g4配体的小结合分子稳定g-四链体可以阻止端粒酶维持癌细胞中端粒的完整性.g-四链体也可以存在于基因组的其他部分,尤其是在癌基因的启动子序列中,并且也是有趣的药物靶标.这里,我们描述了一系列新的新型双三唑的开发,这些双三唑旨在稳定地将g-四链体结构作为g4配体来稳定.fret分析显示两种化合物是中等有效的g4结合剂,对由hsp90A启动子序列形成的四链体具有特定的亲和力,并且对g-四链体dna具有非常好的选择性与双链dna.但是,Cd光谱法未能提供有关由于其与配体之一相互作用而导致的人类端粒g
DOI:10.1039/c7Ra07257K

专利信息

专利号:US-8053165-B2
优先权日:2008-03-18
标 题:Hydroxyl-containing monomer, polymer, resist composition, and patterning process
发明人：KINSHO TAKESHI; OHASHI MASAKI; HASEGAWA KOJI; WATANABE TAKERU
权利人:SHINETSU CHEMICAL CO
摘要:A hydroxyl-containing monomer of formula (1) is provided wherein R 1 is H, F, methyl or trifluoromethyl, R 2 and R 3 are monovalent C 1 -C 15 hydrocarbon groups, or R 2 and R 3 may form an aliphatic ring. The monomers are useful for the synthesis of polymers which have high transparency to radiation of up to 500 nm and the effect of controlling acid diffusion so that the polymers may be used as a base resin to formulate radiation-sensitive resist compositions having a high resolution.

专利号:US-7615634-B2
优先权日:2003-02-10
标题:4-aminopyrimidine-5-one derivatives
发明人：BARTKOVITZ DAVID JOSEPH; CHU XIN-JIE; DING QINGJIE; JIANG NAN; LOVEY ALLEN JOHN; MOLITERNI JOHN ANTHONY; MULLIN JR JOHN GUILFOYLE; VU BINH THANH; WOVKULICH PETER MICHAEL
权利人:HOFFMANN LA ROCHE
摘要:Novel intermediate compounds are disclosed. These compounds are useful in the synthesis of 4-aminopyrimidine-5-one derivatives that inhibit cyclin-dependent kinases, in particular cyclin-dependent kinase 4 (Cdk4). The 4-aminopyrimidine-5-one derivatives and their pharmaceutically acceptable salts have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors.

专利号:US-2009111810-A1
优先权日:2007-10-23
标题:Substituted pyrimidine-5-carboxamide and 5-carboxylic ester kinase inhibitors
发明人：CONNOLLY PETER J; HUGHES TERRY V; WETTER STEVEN K
权利人:CONNOLLY PETER J; HUGHES TERRY V; WETTER STEVEN K
摘要:The present invention is directed to substituted pyrimidine-5-carboxamide and 5-carboxylic ester compounds of Formula (I): n n n n n n n n n n and forms thereof wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and L are as defined herein and their synthesis and use as kinase inhibitors for treating a chronic or acute protein kinase mediated disease.

专利号:US-8367825-B2
优先权日:2005-12-21
标 题 :Substituted pyrimidinyl oxime kinase inhibitors
发明人：GUOZHANG XU; LEE LILY; HUGHES TERRY V; WETTER STEVEN K; CONNOLLY PETER J; ABAD MARTA C; EMANUEL STUART L; KAMACHI PRABHA S; MIDDLETON STEVEN A; BATTISTA KATHLEEN A; BIGNAN GILLES C
权利人:JANSSEN PHARMACEUTICA NV; GUOZHANG XU; LEE LILY; HUGHES TERRY V; WETTER STEVEN K; CONNOLLY PETER J; ABAD MARTA C; EMANUEL STUART L; KAMACHI PRABHA S; MIDDLETON STEVEN A; BATTISTA KATHLEEN A; BIGNAN GILLES C
摘要:The present invention is directed to substituted pyrimidine compounds of formula (I): n nand forms thereof, their synthesis and use for treating, preventing or ameliorating a chronic or acute protein kinase mediated disease, disorder or condition.