CAS: 6119-70-6; (R)-(6-Methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-Vinylquinuclidin-2-yl)Methanol Sulfate Hydrate(2:1:4)

奎宁硫酸盐 在 水体系中,用 甲醇作为反应溶剂,反应 120.0H,获得 Quinine; Hydrogen Sulfate Dihydrate
参考文献:Us2009/163540
标题:Us2009/163540

专利信息

专利号:US-8450365-B2
优先权日:2009-05-12
标 题 :Efficient synthesis of galanthamine
发明人：MAGNUS PHILIP D; FAUBER BEN; SANE NEERAJ
权利人:MAGNUS PHILIP D; FAUBER BEN; SANE NEERAJ; UNIV TEXAS
摘要:The present invention relates to methods for the synthesis of galanthamine, morphine, intermediates, salts and derivatives thereof. In preferred embodiments, the invention relates to methods for improving the efficiency and overall yield of said morphine, morphine related derivatives and intermediates thereof. In further embodiments, the invention relates to methods for improving the efficiency and overall yield of galanthamine and intermediates thereof.

专利号:US-4699984-A
优先权日:1984-09-17
标 题 :Preparation of intermediates to 6-fluoro-7-(2,6-dimethylpyridyl)quinoline carboxylic acids and compounds
发明人：SINGH BALDEV
权利人:STERLING DRUG INC
摘要:Shown is the process which comprises heating 4-(2-fluorophenyl)-2,6-dimethyl-3,5-pyridinedicarboxylic acid to produce a mixture of 4-(2-fluorophenyl)-2,6-dimethylpyridine and 2,4-dimethyl-5H-[1]benzopyrano[3,4-c]pyridin-5-one, separating the components of said mixture and nitrating 4-(2-fluorophenyl)-2,6-dimethylpyridine to produce 4-(2-fluoro-5-nitrophenyl)-2,6-dimethylpyridine. Also shown are the 3-step synthesis of 4-(2-fluorophenyl)-2,6-dimethyl-3,5-pyridinedicarboxylic acid from 2-fluorobenzaldehyde and the five step synthesis of 1-ethyl-6-fluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxylic acid, a highly potent antibacterial agent, starting with 4-(2-fluoro-5-nitrophenyl)-2,6-dimethylpyridine. Other intermediates shown in said five step synthesis include 3-(2,6-dimethyl-4-pyridinyl)-4-fluorobenzeneamine and diethyl 4-fluoro-3-(2,6-dimethyl-4-pyridinyl)anilinomethylenemalonate.

专利号:US-8080397-B2
优先权日:1999-01-29
标 题 :Biocatalystic synthesis of quinic acid and conversion to hydroquinone by recombinant microbes
发明人：FROST JOHN W; FROST KAREN M
权利人:FROST JOHN W; FROST KAREN M; UNIV MICHIGAN STATE
摘要:A bioengineered synthesis scheme for the production of quinic acid from a carbon source is provided. Methods of producing quinic acid from a carbon source based on the synthesis scheme as well as conversion of quinic acid to hydroquinone are also provided.

专利号:US-6613552-B1
优先权日:1999-01-29
标 题:Biocatalytic synthesis of shikimic acid
发明人：FROST JOHN W; FROST KAREN M; KNOP DAVID R
权利人:UNIV MICHIGAN STATE
摘要:A bioengineered synthesis scheme for the production of shikimic acid from a carbon source is provided. Methods of producing shikimic acid from a carbon source based on the synthesis scheme are also provided.

专利号:US-6245937-B1
优先权日:1996-11-29
标题 :Liquid phase parallel synthesis of chemical libraries
发明人：CHENG SOAN; SAUNDERS JOHN
权利人:DUPONT PHARMACEUTICALS RES LAB
摘要:This invention features methods of biphasic synthesis for synthesizing combinatorial libraries and combinatorial libraries of chemical compounds utilizing the template, and combinatorial libraries of chemical compounds formed by the methods of this invention.

专利号:US-6194612-B1
优先权日:1995-10-17
标 题:Template for solution phase synthesis of combination libraries
发明人：BOGER DALE L; CHENG SOAN; MYERS PETER L
权利人:SCRIPPS RESEARCH INST; COMBICHEM INC
摘要:This invention features a template for synthesizing combinatorial libraries, methods of synthesizing combiatorial libraries of chemical compounds utilizing the template, and combinatorial libraries of chemical compounds formed by the methods of this invention.