CAS: 625-77-4; Diacetamide

该化合物是一种有机化合物,其特性为氨化物功能组;它是在水和乙醇等极地溶剂中溶解的白的,白的晶状固体,因其能形成氢联结;N-乙基甲酸盐的分子配方为C4H9NO2,其分子重量约为101.12克/摩尔;该化合物经常用于有机合成,并用作生产药品和农用化学品中的中间体;其结构上有一个乙酰胺协会的乙酰基体,有助于其再活性和潜在应用于各种化学反应;N-乙基甲基甲酸盐在标准条件下具有中度稳定性,但可能在高热或强酸或基中分解;安全数据表明,应谨慎处理该化合物,因为接触皮肤或眼睛时可能会引起刺激.

结构式图片

上下游产品

CAS号60-35-5 乙酰胺 | CAS号108-24-7 乙酸酐 | CAS号1641-36-7 丁基铵乙酸盐 | CAS号75-05-8 乙腈 | CAS号75-36-5 乙酰氯 | CAS号123194-00-3 4-氨基-1-甲基-4-哌啶甲腈 | CAS号830-03-5 4-硝基苯基乙酸酯 | CAS号2032-35-1 2-溴-1,1-二乙氧基乙烷 | CAS号86774-75-6 2,4,6-trimethyl... | CAS号64-19-7 冰醋酸 | CAS号557-30-2 乙二肟 | CAS号3148-73-0 N,N'-二乙酰基肼 | CAS号14277-00-0 N'-phenylethani... | CAS号71607-45-9 N,N-diphenylace... | CAS号103-84-4 N-乙酰苯胺 | CAS号14674-17-0 2-(o-Nitropheny... | CAS号60-35-5 乙酰胺 | CAS号2302-87-6 Acetic acid,2-(... | CAS号588-46-5 N-乙酰苄胺 | CAS号57152-94-0 (E)-3-phenyl-N-...

合成工艺路线路线简述

  • 616-05-7 = 625-77-4 + 823-94-9 + 10601-70-4 [标题:Reaction Conditions
    标题:High-Temperature Transnitrilation Of 2-Bromocaproic Acid
    作者:Polivin,Yu. N.; Et Al
    参考文献:Izvestiya Akademii Nauk Sssr 日期:1990 卷标:(7) 页码:1682-4
N-乙基乙酰胺置于吡啶,N-羟基邻苯二甲酰亚胺,Sodium Perchlorate体系中,用 乙腈 作为反应溶剂,以69%的收率获得产物二乙酰基胺
参考文献:Masui,Masaichiro; Hara,Seijiro; Ozaki,Shigeko,Chemical And Pharmaceutical Bulletin,1986,Vol. 34,# 3,P. 975-979
标题:Masui,Masaichiro; Hara,Seijiro; Ozaki,Shigeko,Chemical And Pharmaceutical Bulletin,1986,Vol. 34,# 3,P. 975-979

海关参考信息

专利信息


专利号:US-2024024489-A1
优先权日:2020-11-20
标 题:Protected disaccharides, their process of preparation and their use in the synthesis of zwitterionic oligosaccharides, and conjugates thereof
发明人:MULARD LAURENCE; DHARA DEBASHIS; PFISTER HELENE; PAOLETTI JULIE; PHALIPON ARMELLE; GUERREIRO-INVERNO CATHERINE
权利人:PASTEUR INSTITUT
摘要:The present invention provides zwitterionic oligosaccharides, in particular fragments of the surface polysaccharides from Shigella sonnei and Shigella sonnei conjugates comprising them. The present invention also provides protected disaccharides, their process of preparation and their use in the synthesis of zwitterionic oligosaccharides, and conjugates thereof, the disaccharide repeating unit of Shigella sonnei being: (I)

专利号:US-4892687-A
优先权日:1986-10-08
标题:Process for synthesis of amidoacids using a cobalt catalyst and a bidental phosphine ligand
发明人:LIN JIANG-JEN
权利人:TEXACO INC
摘要:A process is disclosed for producing N-acetyl-aminoacid which comprises reacting a feedstock from the group consisting of simple olefins, acetamide and synthesis gas with a catalyst comprising a cobalt-containing compound promoted by a bidental-phosphine ligand in a solvent at a pressure of 500 psi or greater and a temperature of 50 DEG C. or greater. The presence of the ligand increases both reaction rate and cobalt catalyst stability.

专利号:WO-2024258356-A1
优先权日:2023-06-16
标 题 :Isomeric aminophytosphingosines, a method of their production and use
发明人:MARTINKOVA MIROSLAVA; SPAKOVA RASCHMANOVA JANA; NOVOTNA MICHAELA; PONCAKOVA TATIANA; BAGO PILATOVA MARTINA; KESELAKOVA ALEXANDRA; GAL PETER
权利人:UNIVERZITA PAVLA JOZEFA SAFARIKA V KOSICIACH
摘要:Stereoselective synthesis of 3,4-diamino-1,2-diols possessing a long hydrocarbon chain was carried out via olefin cross-metathesis between a commercial tetradec-1-ene and known diastereoisomeric trichloroacetamides prepared in our laboratory. Subsequent modification of the obtained coupling products used an approach based on functional group interconversions, which was accompanied by the rational choice of deprotection protocols. The resulting molecules represent novel isomeric amino analogues of natural D-ribo-phytosphingosine, which on the basis of their structure could have the status of skin sphingomimetics, i.e. substances that can affect the properties of the skin and dermis in terms of improving the quality of the lipid matrix (e.g. change in permeability, hydration), or stimulating the biosynthesis of procollagen in deeper structures. The cytotoxic effect of the prepared aminoisophytosphingosines was examined on two human non-malignant cell lines (BJ and HaCaT) and the screening results confirmed the safety in at least three representatives of the prepared series of compounds. In addition, the ability of the synthesized derivatives to inhibit cancer cell proliferation was also investigated. The results of preliminary anticancer screening showed weaker antiproliferative potential of these unusual sphingoid bases.

专利号:US-4789758-A
优先权日:1985-01-07
标题 :Process for the production of an N-protected-L-α-aspartyl-L-phenylalanine
发明人:TAKEMOTO TADASHI; YUKAWA TOSHIHIDE; HISAMITSU KUNIO
权利人:AJINOMOTO KK
摘要:A process is described for the synthesis of N-protected-L-α-aspartyl-L-phenylalanine by both (a) the rection of an N-protected-L-aspartic anhydride and a R 1 -L-phenylalanine, and (b) the reaction of an N-protected-L-aspartic anhydride and L-phenylalanine in an aqueous medium in the presence of R 2 , where R 1 may be an alkali metal salt, alkaline earth metal salt, ammonium salt or organic amine salt, and R 2 may be an ammonium salt or an alkali or alkaline earth metal salt of an inorganic or organic acid.

专利号:WO-2025068371-A1
优先权日:2023-09-28
标 题:Inhibitors of the proprotein convertase furin, methods of production thereof and use
发明人:STEINMETZER TORSTEN; LANGE ROMAN WERNER; BOLLER CHARLOTTE; FRIEBERTSHÄUSER EVA; BLOCH KONSTANTIN
权利人:PHILIPPS UNIV MARBURG
摘要:The invention relates to novel inhibitors of the serine protease furin and to related furin-like proprotein convertases according to claim 1, and to methods of synthesis thereof and to use for production of medicaments for treatment of furin-dependent viral and bacterial infection diseases, and other disorders involving furin, such as cystic fibrosis, cancer, osteoarthritis, hypertension, and neurodegenerative disorders.

专利号:US-5236879-A
优先权日:1990-12-06
标 题 :Catalyst for purifying exhaust gas
发明人:INOUE SHUNJI; KASAHARA SENSHI; SEKIZAWA KAZUHIKO
权利人:TOSOH CORP
摘要:A catalyst for purifying an exhaust gas comprising: a crystalline aluminosilicate containing a rare earth or alkaline earth metal produced by allowing a rare earth or alkaline earth metal salt to exist in reactants for a synthesis of a crystalline aluminosilicate, and introduced therein, at least one element selected from the consisting of the group Ib metals and VIII metals of the periodic table.
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主要参考文献


1: Zhang F, Liu Y, Ma KQ, Yan H, Luo Y, Wu FC, Yang CT, Hu S, Peng SM. Highly selective extraction of uranium from wastewater using amine-bridged diacetamide- functionalized silica. J Hazard Mater. 2022 Aug 5;435:129022. doi: 10.1016/j.jhazmat.2022.129022. Epub 2022 Apr 27. 68(Pt 4):o933. doi: 10.1107/S1600536812008653. Epub 2012 Mar 3.
3: Wang JL. N,N'-Di-8-quinolyl-2,2'-(o-phenyl-ene-di-oxy)diacetamide. Acta Crystallogr Sect E Struct Rep Online. 2009 Oct 23;65(Pt 11):o2844. doi: 10.1107/S1600536809041312.
4: Li XF, An Y, Huang QH, Wen YH. N,N-Bis(quinolin-8-yl)-2,2'-[(1,3,4-thia- diazole-2,5-di-yl)bis-(sulfanedi-yl)]diacetamide monohydrate. Acta Crystallogr Sect E Struct Rep Online. 2011 Dec 1;67(Pt 12):o3291. doi: 10.1107/S1600536811047222. Epub 2011 Nov 12.

合成参考文献


参考文献:10.1038/ncomms14226
摘要:Niu L, Yi H, Wang S, Liu T, Liu J, Lei A. Photo-induced oxidant-free oxidative C–H/N–H cross-coupling between arenes and azoles. Nature Communications. 2017 Feb 01;8(1):14226. doi: 10.1038/ncomms14226.
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