CAS: 96515-79-6; 5-Chloro-2-Fluorobenzaldehyde

上下游产品

CAS号352-33-0 对氯氟苯 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号768-66-1 2,2,6,6-四甲基哌啶 | CAS号452-66-4 5-氯-2-氟甲苯 | CAS号20028-71-1 6-氯喹唑啉-2-胺 | CAS号869478-16-0 tert-Butyl 4-(4... | CAS号67092-18-6 2,6-二氯喹唑啉

5-氯-2-氟甲苯置于chromium(Vi) Oxide,硫酸,乙酸酐体系中,化学反应 2.0H,反应生成 5-氯-2-氟苯甲醛
参考文献:具有4-(二取代苯基)环和氨基烷基酯基的1,4-二氢吡啶衍生物的合成和降压活性:高效且持久的钙拮抗剂.
标题:具有4-(二取代苯基)环和氨基烷基酯基的1,4-二氢吡啶衍生物的合成和降压活性:高效且持久的钙拮抗剂.
摘要:合成了带有4-(二取代的苯基)环和氨基乙基酯或氨基-2,2-二甲基-丙基酯的新的1,4-二氢吡啶衍生物,并在血压正常的大鼠和自发性高血压的大鼠中检查了它们的降压活性.讨论了苯基取代基和酯基对降压活性的影响.几种化合物显示出比尼卡地平更有效的降压活性,大多数化合物具有更长的作用时间.其中,7B.Hcl(tc-81)表现出强效和持久的活性,被选作进一步药理研究的候选药物.
DOI:10.1248/cpb.40.2049

专利信息

专利号:US-11034695-B2
优先权日:2016-09-23
标 题:Dopamine-β-hydroxylase inhibitors
发明人：SOARES DA SILVA PATRÃ?CIO; ROSSI TINO; KISS LASZLO ERNO; BELIAEV ALEXANDER; LEAL PALMA PEDRO NUNO
权利人:BIAL—PORTELA & CA S A; BIAL—PORTELA & Cᵃ S A
摘要:This invention relates to: (a) compounds of Formula Ia (with R1, R4, R5, R6, n and A as defined herein) and pharmaceutically acceptable salts or solvates thereof that are useful as dopamine-β-hydroxylase inhibitors; (b) pharmaceutical compositions comprising such compounds, salts or solvates; (c) the use of such compounds, salts or solvates in therapy; (d) therapeutic methods of treatment using such compounds, salts or solvates; and (e) processes and intermediates useful for the synthesis of such compounds.

专利号:CN-104098577-B
优先权日:2014-07-12
标 题:A kind of high-efficiency synthesis method of azoloindolone condensed heterocyclic ring