专利号:WO-2024168123-A1 优先权日:2023-02-09 标 题 :Synthesis of core 2 o-sialyl lewis-x polysaccharides 发明人:CHAIKOF ELLIOT; DHAKAL BIBEK; MANDHAPATI APPI; ERADI PRADHEEP 权利人:BETH ISRAEL DEACONESS MEDICAL CT INC 摘要:Provided herein are methods and compounds useful in the preparation of Core 2 O -sialyl Lewis x polysaccharides including compounds of Formula (C).
专利号:US-6005103-A 优先权日:1993-11-19 标题 :Pyrone derivatives as protease inhibitors and antiviral agents 发明人:DOMAGALA JOHN MICHAEL; LUNNEY ELIZABETH; PARA KIMBERLY SUZANNE; PRASAD JOSYULA VENKATA NAGENDR; TAIT BRADLEY DEAN 权利人:WARNER LAMBERT CO 摘要:The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized pyrones and of related structures.
专利号:WO-2018192923-A1 优先权日:2017-04-18 标题 :Alpha alkylation of aldehyde with a polycyclic olefin 发明人:QUINTAINE JULIE; MACMILLAN DAVID W C 权利人:FIRMENICH & CIE 摘要:The present invention relates to the field of organic synthesis and more specifically to the alpha alkylation of an aldehyde with a polycyclic olefin followed by a ring opening step in order to provide compound of formula (I) in the form of any one of its stereoisomers or a mixture thereof and wherein R represents a hydrogen atom or C 1-8 linear alkyl group; R 1 , R 2 , R 3 and R 4 represent, when taken separately, independently of each other, a hydrogen atom or a C 1-2 linear alkyl group or a C 3-4 linear or branched alkyl group; or R 2 and R 3 , when taken together, represent a C 4-10 linear, branched or cyclic alkanediyl group and n is 1 or 2.
专利号:US-9308194-B2 优先权日:2013-11-28 标 题:Indanyloxyphenylcyclopropanecarboxylic acids 发明人:LINGARD IAIN; HAMPRECHT DIETER 权利人:BOEHRINGER INGELHEIM INT 摘要:A compound of formula I, n nwherein the groups R 1 , R 2 , R 3 , X, m, and n are defined as in claim 1 , which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2. Furthermore, the invention relates to novel intermediates, useful for the synthesis of compounds of formula I.
专利号:EP-0729465-B1 优先权日:1993-11-19 标 题:Pyrone derivatives as protease inhibitors and antiviral agents 发明人:DOMAGALA JOHN MICHAEL; LUNNEY ELIZABETH; PARA KIMBERLY SUZANNE; PRASAD JOSYULA VENKATA NAGENDR; TAIT BRADLEY DEAN 权利人:PARKE DAVIS & CO 摘要:The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized pyrones and of related structures.
专利号:NL-9100854-A 优先权日:1990-05-17 标 题 :METHOD FOR PREPARING INTERMEDIATES USE FOR THE SYNTHESIS OF BENZODIAZEPINES.
[参考文献]: Sarah E Appleton, Et Al. Monomeric, One- And Two-Dimensional Networks Incorporating (2,6-Me2C6H3S)2Pb Building Blocks. Dalton Trans. 2004 Nov 7:(21):3515-20.
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