CAS: 1315478-13-7; 2-(2-Butyl-4-Hydroxy-6-Methylpyrimidin-5-yl)-N,N-Dimethylacetamide

英文名称2-(2-Butyl-4-Hydroxy-6-Methylpyrimidin-5-yl)-N,N-Dimethylacetamide
中文名称2-丁基-1,6-二氢-N,N,4-三甲基-6-氧代-5-嘧啶乙酰胺
IUPAC名称2-(2-butyl-4-hydroxy-6-methylpyrimidin-5-yl)-N,N-dimethylacetamide
其它别名2-(2-Butyl-4-Methyl-6-Oxo-1,6-Dihydropyrimidin-5-yl)N,N-Dimethylacetamide; 2-(2-Butyl-4-Hydroxy-6-Methylpyrimidin-5-yl)-N,N-Dimethylacetamide; 2-Butyl-1,6-Dihydro-N,N,4-Trimethyl-6-Oxo-5-Pyrimidineacetamide; Butyl-1,6-Dihydro-N,N,4-Trimethyl-6-Oxo-5-Pyrimidineacetamide; 2- (2-Butyl-4-Hydroxy-6-Methylpyrimidin-5-yl) -N, N-Dimethylacetamide / Non-Masartan Intermediate; Fimasartan Impurity A; Fimasartan-1; 2-(2-N-Butyl-4-Hydroxy-6-Methyl-Pyrimidin-5-yl)-N,Ndimethylacetamide
CAS编号1315478-13-7
MFCD编号:MFCD28098708
FDA UNII编号:M69UA4K5A8
分子式:C13H21N3O2
分子量:251.33
产品CID: 482390
产品分类医药中间体 → 嘧啶类化合物

相似结构搜索
InChIKey: OAMDXZTUOHORAO-UHFFFAOYSA-N
InChI=1S/C13H21N3O2/c1-5-6-7-11-14-9(2)10(13(18)15-11)8-12(17)16(3)4/h5-8H2,1-4H3,(H,14,15,18)…
计算化学: 氢键受体数3.0氢键供体数1.0可旋转键数5.0

MSDS等安全信息

警示词Warning
危险描述H302-H315-H319-
防范说明P264-P270-P280-P301+P312+P330-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362+P364-P501-

上下游产品

2-丁基-1,6-二氢-4-甲基-6-氧代-5-嘧啶乙酸 2-(2-N-Butyl-4-Hydroxy-6-Methyl-Pyrimidin-5-yl)Acetic Acid 1315478-16-0
Methyl 2-(2-Butyl-4-Methyl-6-Oxo-1,6-Dihydropyrimidin-5-yl)Acetate
2-丁基-1,4-二氢-6-甲基-4-氧代-5-嘧啶乙酸乙酯 2-N-Butyl-5-Ethoxycarbonylmethyl-4-Hydroxy-6-Methylpyrimidine

合成工艺路线路线简述

合成目标产物 2-(2-Butyl-4-Hydroxy-6-Methylpyrimidin-5-yl)-N,N-Dimethylacetamide 主要起始原料 2-Butyl-1,6-Dihydro-4-Methyl-6-Oxo-5-Pyrimidineacetic Acid And Dimethylamine Hydrochloride
(文献来源)合成步骤主要原料 2-Butyl-1,6-Dihydro-4-Methyl-6-Oxo-5-Pyrimidineacetic Acid 和 Dimethylamine Hydrochloride

戊腈置于n-甲基吗啉,盐酸,盐酸-N-乙基-N'-(3-二甲氨基丙基)碳二亚胺,Potassium Hydroxide体系中,用甲醇,二氯甲烷用作溶剂,化学反应 29.0H,反应生成2-丁基-1,6-二氢-N,N,4-三甲基-6-氧代-5-嘧啶乙酰胺
参考文献:一种非马沙坦的制备方法
标题:一种非马沙坦的制备方法
摘要:本发明公开了非马沙坦的一种制备方法,以戊腈为原料制得戊脒盐酸盐,再与乙酰丁二酸二乙酯进行关环反应,酰胺化反应制得2‑(2‑正丁基‑4‑羟基‑6‑甲基嘧啶‑5‑基)‑n,N‑二甲基乙酰胺(中间体ⅱ),中间体ⅱ经劳森试剂硫代羰基化得2‑(2‑正丁基‑4‑羟基‑6‑甲基嘧啶‑5‑基)‑n,N‑二甲基硫代乙酰胺(中间体ⅲ),中间体ⅲ经n‑烷基化反应及脱三苯甲基保护基团,即制得非马沙坦.本发明制备方法具有反应选择性高,合成收率高,反应效率高等优点.