CAS: 135944-09-1; Fmoc-D-Hophe-Oh

相似化合物

100564-78-1 1012-05-1 127862-89-9

上下游产品

D-homophenylalanine N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

D-苯基丁氨酸,9-芴甲基-N-琥珀酰亚胺基碳酸酯置于sodium Carbonate体系中,用 1,4-二氧六环,水 用作溶剂,以71.7%的收率获得fmoc-D-高苯丙氨酸
参考文献:Preptin Analogues: Chemical Synthesis,Secondary Structure And Biological Studies
标题:Preptin Analogues: Chemical Synthesis,Secondary Structure And Biological Studies
摘要:Peptide Hormones That Modulate Insulin Secretion Have Been Recognized To Have Therapeutic Potential,With Peptides Such As Amylin (Pramlintide Acetate,Symlin) And Exendin‐4 (Exenatide,Byetta) Now Commercially Available. Preptin Is A Peptide That Has Been Shown To Increase Insulin Secretion In Vitro And In Vivo. Here,We Describe The First Chemical Synthesis And Analysis Of A Short Series Of Preptin Analogues Based On The Rat Preptin Sequence. Phe 21 In The Preptin Sequence Was Substituted With The Non‐protein Amino Acids D‐phe,D‐hphe,3‐aminobenzoic Acid And 1‐aminocyclooctane‐1‐carboxylic Acid,Which Rendered The Preptin Analogues Resistant To Chymotryptic Protease Hydrolysis At This Position. Substitution Of Phe 21 With These Non‐protein Amino Acids Did Not Abrogate The Insulin Secretory Effect Of Preptin,With Analogues Showing A Similar Dose‐dependent Effect On Insulin Secretion From βtc6‐f7 Mouse β‐cells In Both The Presence And Absence Of Glucose As Unmodified Rat Preptin. Further Studies On The Stability Of The Preptin Analogues And Their Effect On Insulin Secretion Are In Progress.
Doi:10.1111/cbdd.12168

专利信息

专利号:US-8410028-B2
优先权日:2003-12-17
标 题:Methods for synthesis of encoded libraries
发明人：MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A
权利人:MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A; GLAXOSMITHKLINE LLC
摘要:The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.

专利号:US-2007042401-A1
优先权日:2003-12-17
标题 :Methods for synthesis of encoded libraries

专利号:US-2012245040-A1
优先权日:2003-12-17
标题 :Methods for synthesis of encoded libraries

专利号:US-2009062147-A1
优先权日:2003-12-17
标 题:Methods for synthesis of encoded libraries

专利号:US-7972994-B2
优先权日:2003-12-17
标 题 :Methods for synthesis of encoded libraries

专利号:US-7935658-B2
优先权日:2003-12-17
标 题 :Methods for synthesis of encoded libraries