CAS: 159991-23-8; Boc-D-3-Abu-Oh

相似化合物

52815-19-7 158851-30-0 193954-26-6

上下游产品

CAS号24424-99-5 二碳酸二叔丁酯 | CAS号28267-25-6 rac-3-氨基异丁酸-d3盐酸盐 | CAS号3775-73-3 (R)-3-氨基丁酸 | CAS号159877-47-1 (r)-n-b°C-3-氨基丁酸甲酯 | CAS号186521-98-2 (3S)-3-b°C-氨基-1... | CAS号186581-53-3 重氮甲烷 | CAS号3744-87-4 B°C-DL-丙氨酸 | CAS号869468-34-8 (+)-(4R)-4-[(te...

Boc-Dl-3-氨基乙酸置于麻黄碱体系中,用 乙醇 用作溶剂,以37.1 G的收率获得(3R)-3-[[(1,1-二甲基乙炔氧基)羰基]氨基]-丁酸
参考文献:(R)-3-氨基丁醇的制备方法
标题:(R)-3-氨基丁醇的制备方法
摘要:本发明涉及药物中间体合成技术领域,具体公开了一种度鲁特韦中间体(R)‑3‑氨基丁醇的制备方法,是以3‑(boc‑氨基)丁酸为起始原料,经过手性拆分得到式ⅰ化合物;再经过硼氢化钠和路易斯酸还原得到式ⅱ化合物;最后氨基脱保护得到(R)‑3‑氨基丁醇.本发明方法所用的原料价廉易得,反应条件温和,安全性可靠,工艺稳定性非常好,收率高,光学纯度高,绿色环保,适合于工业化生产.

专利信息

专利号:US-2012172350-A1
优先权日:2009-09-11
标题 :Histamine h3 inverse agonists and antagonists and methods of use thereof
发明人：CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN
权利人:CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are fused imidazolyl compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including, e.g., neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as, e.g., histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical compositions containing the compounds and their methods of use are also provided herein.

专利号:WO-0102375-A1
优先权日:1999-07-01
标 题:Process for synthesizing oxadiazoles
发明人：DENER JEFFREY MARK; LY CUONG QUOC
权利人:AXYS PHARM INC; DENER JEFFREY MARK; LY CUONG QUOC
摘要:The present invention relates to a process for the synthesis of a single as well as large array of oxadiazole based organic compounds. These oxadiazole based organic compounds are represented by compounds of formula (I).

专利号:WO-0034226-A1
优先权日:1998-12-10
标 题 :Polyamine transport inhibitors
发明人：POULIN RICHARD; AUDETTE MARIE; CHAREST-GAUDREALT RENE
权利人:UNIV LAVAL; ILEX ONCOLOGY INC; POULIN RICHARD; AUDETTE MARIE; CHAREST GAUDREALT RENE
摘要:The application discloses synthetic derivatives of original polyamines in which a carbon atom to the original polyamine comprises an amide group inhibits the e cellular uptake of a natural polyamine by specifically binding a cellular transporter for a natural polyamine . The synthetic derivatives are used to inhibit the activity of a natural polyamine transporter, in the treatment of disorders involving unrestrained cell proliferation and/or differentiation where control of polyamine transport is required When used in combination with a n inhibitor of polyamine synthesis.

专利号:EP-2305808-B1
优先权日:2001-06-20
标 题:Templated molecules and methods for using such molecules
发明人：PEDERSEN HENRIK; GOULIAEV ALEX HAAHR; SAMS CHRISTIAN KLARNER; SLØK FRANK ABILGAARD; FRESKGÃ…RD PER-OLA; HOLTMANN ANETTE; OLSEN EVA KAMPMANN; HUSEMOEN GITTE NYSTRUP; FELDING JAKOB; FRANCH THOMAS; THISTED THOMAS; HYLDTOFT LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER
权利人:NUEVOLUTION AS
摘要:The present invention relates to a method for synthesising templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g . therapeutic activity.

专利号:US-6949679-B1
优先权日:1998-04-21
标 题 :Polyamine transport inhibitors
发明人：POULIN RICHARD; AUDETTE MARIE; CHAREST-GAUDREAULT RENE
权利人:UNIV LAVAL
摘要:The present invention describes the design, synthesis and therapeutic use of a variety of novel inhibitors of polyamine transport. The main feature of this class of transport inhibitors is to incorporate a linker or side chain that prevents the uptake of polyamines and helps to conjugate polyamine analogs to form dimers with high inhibitory potency against polyamine uptake. These new compounds incorporate features that are designed to maximize their chemical and metabolic stability and their ability to bind to the polyamine transporter, and to minimize their toxicity by preventing their absorption by the cells. The purpose of such inhibitors is to prevent the uptake or salvaging of circulating polyamines by rapidly proliferating cells such as tumor cells, in order to potentiate the effect of therapeutic inhibitors of polyamine biosynthesis such as alpha-difluoromethylornithene.

专利号:US-9688980-B2
优先权日:2001-06-20
标 题 :Templated molecules and methods for using such molecules
发明人：PEDERSEN HENRIK; GOULIAEV ALEX HAAHR; FRANCH THOMAS; SAMS CHRISTIAN KLARNER; OLSEN EVA KAMPMANN; SLOK FRANK ABILGAARD; HUSEMOEN GITTE NYSTRUP; FELDING JAKOB; HYLDTOFT LENE; NORREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRODER; THISTED THOMAS; FRESKGARD PER-OLA; HOLTMANN ANETTE
权利人:NUEVOLUTION AS; NUEVOLUTION
摘要:The present invention relates to a method for synthesising templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g. therapeutic activity.