CAS: 180258-46-2; Ethyl 4-Amino-1-Methyl-1H-Imidazole-2-Carboxylate Hydrochloride

相似化合物

109012-23-9 30148-21-1 128293-62-9

1-甲基-4-硝基咪唑-2-羧酸乙酯置于palladium-Carbon 盐酸,氢气体系中,用 乙醚,乙醇,乙酸乙酯 用作溶剂,以78%的收率获得4-氨基-N-甲基咪唑-2-羧酸乙酯盐酸盐
参考文献:Complex Formation Between Dsdna And Pyrrole Imidazole Polyamides
标题:Complex Formation Between Dsdna And Pyrrole Imidazole Polyamides
摘要:提供了一种形成双链dna与杂环,脂肪族氨基酸(特别是ω-氨基酸)和极性末端基团寡聚体复合物的方法和组合物.通过选择合适的靶序列和寡聚体的组成,可以获得具有低解离常数的复合物.复合物的形成可用于特定双链dna序列的识别,用于抑制基因转录,并作为抑制不需要的细胞增殖或不需要的基因表达的治疗方法.

专利信息

专利号:US-6683189-B1
优先权日:1996-02-26
标 题 :Method for the synthesis of pyrrole and imidazole carboxamides on a solid support
发明人：DERVAN PETER B; BAIRD ELDON
权利人:CALIFORNIA INST OF TECHN
摘要:The present invention describes a novel method for the solid phase synthesis of polyamides containing imidazole and pyrrole carboxamides. The polyamides are prepared on a solid support from aromatic carboxylic acids and aromatic amines with high stepwise coupling yields (>99%), providing milligram quantities of highly pure polyamides. The present invention also describes the synthesis of analogs of the natural products Netropsin and Distamycin A, two antiviral antibiotics. The present invention also describes a novel method for the solid phase synthesis of imidazole and pyrrole carboxamide polyamide-oligonucleotide conjugates. This methodology will greatly increase both the complexity and quantity of minor-groove binding polyamides and minor-groove binding polyamide-oligonucleotide conjugates which can be synthesized and tested.

专利号:US-6545162-B1
优先权日:1996-02-26
标 题:Method for the synthesis of pyrrole and imidazole carboxamides on a solid support

专利号:US-6090947-A
优先权日:1996-02-26
标题:Method for the synthesis of pyrrole and imidazole carboxamides on a solid support

专利号:EP-0885189-B9
优先权日:1996-02-26
标题 :Method for the synthesis of poly-pyrrole and poly-imidazole carboxamides on a solid support

专利号:EP-0885189-B1
优先权日:1996-02-26
标题:Method for the synthesis of poly-pyrrole and poly-imidazole carboxamides on a solid support