CAS: 21640-48-2; 3-(3-Chlorophenyl)Propanoic Acid

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乙基3-(3-氯苯基)丙酸酯置于sodium Hydroxide体系中,化学反应 3.0H,以143.2 G的收率获得3-(3-氯苯基)丙酸
参考文献:一种茚酮类化合物的制备方法
标题:一种茚酮类化合物的制备方法
摘要:本发明涉及有机合成领域,特别是涉及一种茚酮类化合物的制备方法.本发明提供一种茚酮类化合物的制备方法,包括:1)将式i化合物与式ii化合物进行缩合反应,制备获得式iii化合物;2)将式iii化合物在碱存在的条件下水解,制备获得式iv化合物;3)将式iv化合物酰化,关环,制备获得式v化合物.本发明所提供的茚酮类化合物的制备方法与现有技术相比,具有原料成本低,操作简便,三废少,收率高等优点,更适合工业化生产,相对于现有技术中的各种茚酮类化合物的制备方法优势明显,具有非常好的产业化前景.

专利信息

专利号:EP-3515880-B1
优先权日:2017-03-17
标题:Methods and compositions for synthesis of encoded libraries
发明人：LI JIN; MORGAN BARRY A; Wan jinqiao; DOU DENGFENG; LIU GUANSAI; CHANG YONG; CHEN QIUXIA; WANG XING; XU YANSHAN; HU DONGYAN; LIU JIAN; CHENG XUEMIN
权利人:HITGEN INC

专利号:US-2020149034-A1
优先权日:2017-03-17
标题:Methods and Compositions for Synthesis of Encoded Libraries

专利号:US-8338565-B2
优先权日:2008-08-20
标 题 :Macrocyclic compounds for inhibition of tumor necrosis factor alpha
发明人：LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P
权利人:LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P; ENSEMBLE THERAPEUTICS CORP
摘要:Disclosed herein are macrocyclic compounds and methods for their synthesis and use. In particular, macrocyclic compounds are disclosed that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.

专利号:CN-113527075-B
优先权日:2021-07-19
标题 :A kind of preparation method of one-step synthesis of 5-chloro-1-indanone

专利号:CN-113527075-A
优先权日:2021-07-19
标题 :A kind of preparation method of one-step synthesis of 5-chloro-1-indanone

专利号:CN-111116507-A
优先权日:2019-12-30
标 题:A kind of synthesis process of indoxacarb