CAS: 216854-23-8; (S)-Tert-Butyl Piperidin-3-Ylcarbamate

相似化合物

309956-78-3 127294-77-3 138060-07-8

上下游产品

CAS号92235-39-7 (S)-2-哌啶酮-3-氨基甲酸叔丁酯 | CAS号607376-86-3 (S)-2-(tert-but... | CAS号56-86-0 L-谷氨酸 | CAS号6525-53-7 谷氨酸二甲酯 | CAS号59279-60-6 N-叔丁氧羰基-L-谷氨酸二甲酯 | CAS号162955-48-8 (S)-(-)-2-(B°C-... | CAS号309962-63-8 (S)-3-N-B°C-3-(... | CAS号876461-55-1 (S)-1-苄氧羰基-3-氨基哌啶 | CAS号1023298-99-8 N-[(3s)-1-(3-氨基... | CAS号168466-85-1 (S)-1-苄基-3-氨基哌啶

谷氨酸二甲酯置于ammonium Hydroxide,Sodium Tetrahydroborate,三乙胺,Calcium Chloride体系中,用 1,4-二氧六环,乙醇,二氯甲烷,水,乙腈 用作溶剂,化学反应 53.0H,反应生成(S)-3-Boc-氨基哌啶
参考文献:手性 α-氨基酸向对映体纯 3-氨基环胺的有效转化
标题:手性 α-氨基酸向对映体纯 3-氨基环胺的有效转化
摘要:摘要 对映异构纯的 3-氨基环胺,如 3-氨基吡咯烷,3-氨基哌啶和 2,3,4,5,6,7-六氢-1H-氮杂已从光学活性的天然α-氨基酸,例如 L-天冬氨酸,L-谷氨酸,L-2-氨基己二酸及其对映体.
Doi:10.1080/00397919808004949

专利信息

专利号:WO-2023091726-A1
优先权日:2021-11-18
标题:Inhibitors of cyclin‑dependent kinase 12 (cdk12)
发明人：BENOIT GUILLAUME; CARULLI JOHN; CHEN FEI; CHUAQUI CLAUDIO; CIBLAT STEPHANE; COOPER ELLIOT; DAGENAIS ROBIN; HU SHANHU; KABRO ANZHELIKA; LAPLACA DEREK; MARINEAU JASON; MOEBIUS DAVID; MOON DIANE; SOLODININ ANDREI; WHITMORE KENNETH
权利人:SYROS PHARMACEUTICALS INC
摘要:The present invention provides chemical compounds that inhibit one or more families of kinases (e.g., serine/threonine kinases, including one or more of the families of CDK proteins, and in particular, CDK12). More specifically, the present invention provides CDK12 inhibitors, of formula (I), pharmaceutically acceptable salts and isotopically labeled derivatives thereof, pharmaceutical compositions containing the compounds/inhibitors, and methods of their synthesis and use in treating proliferative diseases (e.g., a bladder cancer, a breast cancer, Ewing's sarcoma, a gastric cancer, a gastrointestinal cancer, a hematologic cancer, a lung cancer (e.g., small cell lung cancer (SCLC)), an ovarian cancer (e.g., a high grade serous ovarian cancer), a pancreatic cancer (e.g., pancreatic ductal adenocarcinoma (PDAC)), a brain cancer (e.g., glioblastoma), or a prostate cancer), alone or in combination with a second therapeutic agent. The proliferative disease can be a cancer, benign neoplasm, or pathologic angiogenesis, and any of the therapeutic methods or uses described herein can include a step of diagnosing the patient's disease. In other embodiments of the invention, the compositions described herein (e.g., the compounds, pharmaceutical compositions, and kits containing them) are used for the treatment of myotonic dystrophy (type 1 or type 2).

专利号:CA-2743700-C
优先权日:2008-12-15
标题 :Stereoselective synthesis of piperidine derivatives

专利号:EP-2376477-A2
优先权日:2008-12-15
标 题 :Stereoselective synthesis of piperidine derivatives

专利号:CN-102093260-B
优先权日:2009-12-14
标 题 :Stereospecific Synthesis of Piperidine Derivatives

专利号:CN-102093260-A
优先权日:2009-12-14
标 题:Stereospecific Synthesis of Piperidine Derivatives

专利号:WO-2010077798-A2
优先权日:2008-12-15
标 题 :Stereoselective synthesis of piperidine derivatives