CAS: 2435-50-9; Pyrimidine-4-Carbaldehyde

上下游产品

CAS号3438-46-8 4-甲基嘧啶 | CAS号25746-87-6 4-嘧啶甲醛,二甲基乙缩醛 | CAS号2941-72-2 6-甲氧基-2-甲基苯并噻唑 | CAS号49689-16-9 [1,2,3]-triazol... | CAS号33581-98-5 4-羟甲基嘧啶 | CAS号50305-79-8 4-Pyrimidinecar...

4-甲基嘧啶置于叔丁基过氧化氢,Selenium(Iv) Oxide体系中,用 1,4-二氧六环 用作溶剂,化学反应 0.5H,以72%的收率获得嘧啶-4-甲醛
参考文献:在叔丁基过氧化氢存在下,二氧化硒对 N-杂芳族化合物活性甲基的氧化作用得到改善
标题:在叔丁基过氧化氢存在下,二氧化硒对 N-杂芳族化合物活性甲基的氧化作用得到改善
摘要:在二恶烷中存在叔丁基过氧化氢的情况下,使用seo 2 对包括双环和单环化合物在内的n-杂芳族化合物的活性甲基的氧化得到显着改善,从而以中等至非常好的收率获得相应的醛或羧酸.与没有叔丁基过氧化氢的常规seo 2 氧化相比,本氧化进行更温和和更有选择性地形成醛而不是羧酸.
Doi:10.3987/com-02-9702

专利信息

专利号:US-4835280-A
优先权日:1985-01-18
标 题 :Indoline compounds for synthesis of pharmaceutically active pyrrolobenzimidazoles
发明人：MARTENS ALFRED; HOELCK JENS-PETER; BERGER HERBERT; MUELLER-BECKMAN BERND; STREIN KLAUS; ROESCH EGON
权利人:BOEHRINGER MANNHEIM GMBH
摘要:The present invention provides Indolines of the formula: (II) (III) ps useful to provide pharmaceutically active pyrrolobenzimidazoles or tautomers thereof, of the formula: (I) These compounds are useful for treating heart or circulatory diseases, especially those which respond to a change of blood pressure, an increase in cardiac output and/or a change in micro-circulation.

专利号:US-5998451-A
优先权日:1987-10-19
标 题 :Substituted tetralins, chromans and related compounds in the treatment and related compounds in the treatment of asthma, arthritis and related diseases
发明人：EGGLER JAMES F; MARFAT ANTHONY; MELVIN JR LAWRENCE S
权利人:PFIZER
摘要:Substituted tetralins, chromans and related compounds which, by inhibiting 5-lipoxygenase enzyme and/or blocking leukotriene receptors, are useful in the prevention or treatment of asthma, arthritis, psoriasis, ulcers, myocardial infarction and related disease states in mammals, pharmaceutical compositions thereof, a method of treatment therewith, and to intermediates useful in the synthesis thereof.

专利号:US-8518944-B2
优先权日:2009-10-28
标 题 :Compounds as casein kinase inhibitors
发明人：SUBRAMANYAM CHAKRAPANI; WAGER TRAVIS T
权利人:SUBRAMANYAM CHAKRAPANI; WAGER TRAVIS T; PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:CN-101712680-B
优先权日:2009-09-29
标 题 :A green synthesis method of pyrido[1,2-a]pyrimidin-4-one derivatives

专利号:CN-101712680-A
优先权日:2009-09-29
标 题:A green synthesis method of pyrido[1,2-a]pyrimidin-4-one derivatives