CAS: 33775-94-9; (2-Iodophenyl)(Methyl)Sulfane

上下游产品

2-(Methylthio)aniline Dithiopivalinsaeure-2-iodphenylester 2-Iodo-benzenediazonium; hydrogen sulfate 2-bromo-1-(methylsulfanyl)benzene 2-methylthio-2'-nitrobiphenyl o-iodophenyl chloromethyl sulphide o-(1-decynyl)thioanisole (2-(cyclohex-1-en-1-ylethynyl)phenyl)(methyl)sulfane

2-溴茴香硫醚置于copper(L) Iodide,二乙烯三胺,Sodium Iodide体系中,用 乙腈 用作溶剂,化学反应 24.0H,以52%的收率获得2-碘茴香硫醚
参考文献:铜催化的基于胺的配体体系的芳族-芬克尔斯坦反应
标题:铜催化的基于胺的配体体系的芳族-芬克尔斯坦反应
摘要:一种新型高效且低成本的配体二亚乙基三胺已被用于通过铜催化的finkelstein卤素交换反应在温和条件下促进16种不同溴化底物的碘化.与早期方法相比,不需要使用惰性气氛条件即可获得高收率和纯度.对溶液中催化剂形态的研究表明,在二亚乙基三胺存在下,铜(i)迅速歧化,生成铜(0)和双连接铜(II)络合物,其特征在于x射线衍射.铜(二)配合物在卤素交换反应中也显示出催化活性.相反,使用二甲基乙二胺作为配体没有观测到明显歧化,并且报道了铜(i)二聚配合物和碘化铜(i)四聚体的2D聚合物网络的固态结构.比较了二亚乙基三胺和二甲基亚乙基二胺对铜(i)和铜(II)盐的催化活性,并讨论了可能的机理含义.
Doi:10.1039/c7Cy00538E

专利信息

专利号:US-7884125-B2
优先权日:2008-04-30
标 题:Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues
发明人：STEVENS CHRISTIAN; HEUGEBAERT THOMAS
权利人:UNIV GENT
摘要:The present invention relates to a group of substituted-7-azabicyclo-[2.2.1]heptyl derivatives with biological activity. The present invention also relates to synthetic methods for producing said substituted-7-azabicyclo-[2.2.1]heptyl derivatives. The present invention also relates to certain intermediates for producing such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as a synthetic method for producing such intermediates. The present invention also relates to pharmaceutical compositions comprising such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as their use as medicaments for the treatment of diseases mediated by a Nicotinic Acetylcholine Receptor or a receptor being a member of the Neurotransmitter-gated Ion Channel Superfamily, such as pain, Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy and nicotine addiction.

专利号:US-2009275616-A1
优先权日:2008-04-30
标 题 :Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues

专利号:CN-114213389-A
优先权日:2021-12-30
标题 :Synthesis of Benzo[b]naphtho[2,3-d]thiophene

专利号:CN-114213389-B
优先权日:2021-12-30
标题:Synthesis method of benzo[b]naphtho[2,3-d]thiophene