CAS: 33863-76-2; 1-Bromo-3-Chloro-5-Fluorobenzene

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CAS号4863-91-6 3-氯-5-氟苯胺 | CAS号327056-73-5 3-氯-5-氟苯腈 | CAS号328956-61-2 3-氯-5-氟苯硼酸 | CAS号480438-50-4 3-氯-5-氟苯基溴化镁 | CAS号202001-01-2 (3-溴-5-氯-苯基)-乙酸 | CAS号304854-09-9 6-(3-氯-5-氟苯基)-4... | CAS号56962-04-0 3-溴-5-氯苯酚 | CAS号1321613-01-7 4-溴-2-氯-6-氟苯甲酸 | CAS号1321613-04-0 2,6-二氯-4-(4,4,5... | CAS号121219-16-7 2,3-二氟苯硼酸

3-(3-Bromo-5-Chlorophenyl)-1,1,1,3,5,5,5-Heptamethyltrisiloxane置于potassium Hydrogen Difluoride,Copper(II) Bis(Trifluoromethanesulfonate)体系中,用 乙腈 用作溶剂,化学反应 16.0H,以50%的收率获得1-溴-3-氯-5-氟苯
参考文献:铜介导的具有亲核性氟化物的芳基三硅氧烷的氟化.
标题:铜介导的具有亲核性氟化物的芳基三硅氧烷的氟化.
摘要:报道了一种用于七甲基芳基三硅氧烷的亲核氟化以形成氟代芳烃的方法.在温和的条件下,对于宽范围的具有高官能团耐受性的七甲基三甲硅烷氧基芳烃,反应在存在氟化物的cu(otf)2和khf2存在下进行.该方法与芳基ch键的甲硅烷基化相结合,可以按照两步操作,通过位阻效应控制非活化芳烃的区域选择性氟化.
Doi:10.1002/chem.201905040

专利信息

专利号:US-8487108-B2
优先权日:2005-11-14
标题 :Piperidinyl carbamate intermediates for the synthesis of aspartic protease inhibitors
发明人：BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T
权利人:BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T; VITAE PHARMACEUTICALS INC
摘要:The present invention is directed to aspartic protease inhibitors. Certain aspartic protease inhibitors of the invention can be represented by the following structural formula or a pharmaceutically acceptable salt thereof. The present invention is also directed to pharmaceutical compositions comprising the disclosed aspartic protease inhibitors. The present invention is further directed to methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using the disclosed aspartic protease inhibitors.

专利号:US-9676783-B2
优先权日:2008-10-22
标 题:Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds
发明人：HAAS JULIA; ANDREWS STEVEN W; JIANG YUTONG; ZHANG GAN
权利人:ARRAY BIOPHARMA INC
摘要:Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.

专利号:US-6552018-B1
优先权日:1997-01-27
标 题:Pyrazole derivatives
发明人：EJIMA AKIO; OHSUKI SATORU; OHKI HITOSHI; NAITO HIROYUKI
权利人:DAIICHI SEIYAKU CO
摘要:The present invention relates to cis- and trans-forms of pyrazole derivatives, salts thereof, or agents containing the same, and represented by the general formula (I): n wherein G represents a nitrogen containing saturated heterocyclic structure represented by the following formula: n These compounds exhibit anti-tumor activity on 5-FU-resistant tumors and effects on P glycoprotein expressing, multiple-drug resistant tumors. An example of a pyrazole derivative which demonstrates 50% inhibition of tumor cell growth is 3-[4-(3-chloro-5-fluorophenyl)- 1 piperazinyl]-1-[1-(3-chloro-2-pyridyl)-5-methyl-4-pyrazolyl)-1-trans-propene hydrochloride. Synthesis of the compounds represented by formula (I) can be prepared by any one of various routes such as a Mannich reaction, a Wittig reaction, reductive amination or substitution by allylation.

专利号:DK-2725028-T3
优先权日:2008-10-22
标题:Substituted pyrazolo [1,5-a] pyrimidine compounds as intermediates in the synthesis of kinase inhibitors TRK

专利号:EP-2725028-A1
优先权日:2008-10-22
标题 :Substituted pyrazolo[1,5-]pyrimidine compounds as intermediates in the synthesis of TRK kinase inhibitors

专利号:EP-2725028-B1
优先权日:2008-10-22
标题 :Substituted pyrazolo[1,5-]pyrimidine compounds as intermediates in the synthesis of TRK kinase inhibitors