CAS: 372-38-3; 1,3,5-Trifluorobenzene

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CAS号108-70-3 均三氯苯 | CAS号27074-09-5 2,4,6-trifluoro... | CAS号319-88-0 1,3,5-三氯-2,4,6-三氟苯 | CAS号2106-40-3 2-氯-1,3,5-三氟苯 | CAS号827-13-4 1,2,4-trichloro... | CAS号827-12-3 1,2,3-trichloro... | CAS号28314-80-9 2,4,6-三氟苯甲酸 | CAS号2265-94-3 3,5-二氟硝基苯 | CAS号364-30-7 2,4-二氟-6-硝基苯胺 | CAS号58551-83-0 2,4,6-三氟苯甲醛 | CAS号2368-53-8 1,3-二氯-2,4,6-三氟苯 | CAS号319-88-0 1,3,5-三氯-2,4,6-三氟苯 | CAS号372-39-4 3,5-二氟苯胺 | CAS号315-14-0 2,4,6-三氟硝基苯 | CAS号51788-77-3 2,4,6-三氟苯乙酮 | CAS号41860-63-3 2,4,6-三氟碘苯 | CAS号223785-96-4 Ethanone, 2-chl... | CAS号66684-61-5 1,5-二氟-3-甲氧基-2-硝基苯 | CAS号612-71-5 1,3,5-三苯基苯

2,4,6-三氟苯硼酸置于三氟乙酸,Potassium Hydroxide体系中,用 1,4-二氧六环,水 用作溶剂,化学反应生成1,3,5-三氟苯
参考文献:(杂)芳基硼酸酯的原脱硼:直接与预水解途径和自/自催化
标题:(杂)芳基硼酸酯的原脱硼:直接与预水解途径和自/自催化
摘要:一系列硼酸酯的碱催化水解(arb(Or) 2-> Arb(Oh) 2)和原脱硼化(arb(Or) 2-> Arh)的动力学和机理,包括八种不同的多元醇和 10 种多氟芳基和杂芳基部分,已通过原位和停流 NMR 光谱(19 F,1 H 和11 B),Ph 速率依赖性,同位素夹带进行了研究,2H Kie 和 Ks-Dft 计算.该研究揭示了硼酸酯在碱性水-有机条件下的现象稳定性非常微妙.与通常的假设相反,与相应的硼酸相比,酯化不一定赋予更高的稳定性.此外,酯水解为硼酸可以是整个原脱硼过程的主要成分,当 Ph 值接近硼酸的 P K A时,自催化,自催化和氧化(酚类)催化作用增强酯.
Doi:10.1021/jacs.1C06863

专利信息

专利号:US-5512701-A
优先权日:1995-06-07
标题:Process for the synthesis of vinyl sulfenic acid derivatives
发明人：HOARD DAVID W; LUKE WAYNE D
权利人:LILLY CO ELI
摘要:The present invention is directed to a new process for the synthesis of vinyl sulfenic acid derivatives. These compounds are useful for the synthesis of benzo[b]thiophenes, in particular 2-aryl-benzo[b]thiophenes.

专利号:US-7148356-B2
优先权日:2001-07-13
标题:Process for the catalytic synthesis of biaryls and polymers from aryl compounds
发明人：SMITH III MILTON R; MALECZKA ROBERT E
权利人:UNIV MICHIGAN STATE
摘要:A process for producing organic substituted aromatic or heteroaromatic compounds including biaryl and biheteroaryl compounds in a two-step reaction. In the first step, the aromatic or heteroaromatic compound is borylated in a reaction comprising a borane or diborane reagent (any boron reagent where the boron reagent contains a B—H, B—B or B—Si bond) and an iridium or rhodium catalytic complex. In the second step, a metal catalyst catalyzes the formation of the organic substituted aromatic or heteroaromatic compound from the borylated compound and an electrophile such as an aryl or organic halide, triflate (OSO 2 CF 3 ), or nonaflate (OSO 2 C 4 F 9 ). The steps in the process can be performed in a single reaction vessel or in separate reaction vessels. The present invention also provides a process for synthesis of complex polyphenylenes starting from halogenated aromatic compounds.

专利号:US-11655264-B2
优先权日:2015-11-25
标题:Metallocene compounds, and preparation and use thereof for synthesis of poly-alpha-olefins as lubricating base oil
发明人：WEI DONGCHU; LI BING
权利人:APALENE TECH CO LTD JIAXING
摘要:The present invention relates to a metallocene compound, and preparation and use thereof, and the compound can be used as a catalyst for synthesis of poly-α-olefin as lubricating base oil. The metallocene compound includes a substituted aryl group, a bridged atom, an optionally unsubstituted, 3-mono-substituted or 3,6-disubstituted 5H-indeno [1,2-b] pyridyl group or optionally unsubstituted, 3-mono-substituted or 3,6-disubstituted 5H-indeno [1,2-b] thiopyranyl group, and a metal coordination group. As a catalyst, the metallocene compound is shown to be structurally stable and high in catalytic efficiency, and the preparation of the catalyst is relatively easy in operation, high in yield, low in cost, low in pollution and easy to scale up for industrial production.

专利号:US-2025101006-A1
优先权日:2022-01-31
标题:Process for the synthesis of pyrazolyl derivatives useful as anti-cancer agents
发明人：BAENZIGER MARKUS; GALLOU FABRICE; GUO FENGFENG; HÄNGGI RUDOLF; HAN ENJIAN; JORDINE GUIDO; LI JIALIANG; LIU WEIPENG; MIAO BUKEYAN; RONG SHAOFENG; SANTANDREA ERNESTO; SCHIRNER PAUL BERND; SHEN XIAODONG; WANG CAN; ZHANG HAO
权利人:NOVARTIS AG
摘要:The invention provides a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially KRAS G12C inhibitors. The present invention provides a direct enantioselective chemical manufacturing method of making Compound A, or a pharmaceutically acceptable hydrate or solvent thereof: (I). The invention provides a process for preparing Intermediate B6* comprising reacting Intermediate B4* with Intermediate B5* in an atroposelective coupling reaction, using a chiral catalyst.

专利号:US-10562872-B2
优先权日:2016-02-08
标 题 :Synthesis of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]piperazine
发明人：DINESS FREDERIK; MELDAL MORTEN; JACOBSEN CHRISTIAN BORCH
权利人:H LUNDBECK AS
摘要:The invention relates to a method for synthesis of 1-[2-(2,4-Dimethyl-phenylsulfanyl)-phenyl]piperazine in the presence of a strong base.

专利号:US-6372945-B1
优先权日:1995-06-07
标 题 :Process for the synthesis of vinyl sulfoxides
发明人：AIKINS JAMES A; MILLER RANDAL SCOT; ZHANG TONY Y
权利人:LILLY CO ELI
摘要:The present invention is directed to a new process for the synthesis of vinyl sulfoxides, in particular diarylvinyl sulfoxides