CAS: 380430-53-5; (2-(Ethoxycarbonyl)Phenyl)Boronic Acid

上下游产品

CAS号6630-85-9 2-(2-benzoylphe...

硼酸三异丙酯,苯甲酸乙酯置于2,2,6,6-四甲基哌啶,正丁基锂,溶剂黄146体系中,用 四氢呋喃,正己烷 用作溶剂,化学反应 4.08H,反应生成2-乙氧羰基苯硼酸
参考文献:Synthesis Of Ortho Substituted Arylboronic Esters By In Situ Trapping Of Unstable Lithio Intermediates: 2-(5,5-Dimethyl-1,3,2-Dioxaborinan-2-yl)Benzoic Acid Ethyl Ester
标题:Synthesis Of Ortho Substituted Arylboronic Esters By In Situ Trapping Of Unstable Lithio Intermediates: 2-(5,5-Dimethyl-1,3,2-Dioxaborinan-2-yl)Benzoic Acid Ethyl Ester
摘要:
Doi:10.15227/orgsyn.081.0134

专利信息

专利号:CN-104284891-A
优先权日:2012-03-17
标 题:Conformational Restricted Total Synthesis of Macrocyclic Compounds

专利号:US-10017481-B2
优先权日:2012-03-17
标 题 :Conformationally constrained, fully synthetic macrocyclic compounds
发明人：OBRECHT DANIEL; ERMERT PHILIPP; OUMOUCH SAID; PIETTRE ARNAUD; GOSALBES JEAN-FRANÇOIS; THOMMEN MARC
权利人:POLYPHOR AG
摘要:The conformationally restricted, spatially defined macrocyclic ring system of formula (I) is constituted by three distinct molecular parts: Template A, conformation Modulator B and Bridge C. Macrocycles described by this ring system I are readily manufactured by parallel synthesis or combinatorial chemistry in solution or on solid phase. They are designed to interact with a variety of specific biological target classes, examples being agonistic or antagonistic activity on G-protein coupled receptors (GPCRs), inhibitory activity on enzymes or antimicrobial activity. In particular, these macrocycles show inhibitory activity on endothelin converting enzyme of subtype 1 (ECE-1) and/or the cysteine protease cathepsin S (CatS), and/or act as antagonists of the oxytocin (OT) receptor, thyrotropin-releasing hormone (TRH) receptor and/or leukotriene B4 (LTB4) receptor, and/or as agonists of the bombesin 3 (BB3) receptor, and/or show antimicrobial activity against at least one bacterial strain. Thus they are showing great potential as medicaments for a variety of diseases.