CAS: 38767-72-5; 4-Aminopyridin-2(1H)-One

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上下游产品

CAS号14432-12-3 4-氨基-2-氯吡啶 | CAS号95306-61-9 4-CHLOROPYRIDIN... | CAS号626-03-9 2,4-二羟基吡啶 | CAS号109-09-1 2-氯吡啶 | CAS号2402-95-1 2-氯吡啶-N-氧化物 | CAS号14432-16-7 2-氯-4-硝基吡啶氮氧化物 | CAS号107842-74-0 4-氨基-3-溴吡啶-2-醇

2-氯吡啶-N-氧化物置于盐酸,Sodium Hydroxide,硫酸,硝酸,铁粉体系中,用 乙醇 作为反应溶剂,化学反应 20.0H,反应生成 4-氨基-2-羟基吡啶
参考文献:模拟核苷3-Deaza-2'-脱氧胞苷的合成及其以dna聚合酶为模板的活性
标题:模拟核苷3-Deaza-2'-脱氧胞苷的合成及其以dna聚合酶为模板的活性
摘要:描述了核苷类似物3-Deaza-2'-脱氧胞苷的新合成.dc的n 3-氮参与dg-Dc碱基对的中心氢键.通过研究该dc 3 C核苷的双链体稳定性和模板效应,研究了氢键作为控制dna聚合酶活性的控制因素的相对重要性.含有dg-Dc 3 C碱基对的双链体极不稳定,而发现含有类似核苷的模板仅掺入了互补的dg三磷酸酯,这与含有天然2'-脱氧胞苷的模板的观察结果相似.
DOI:10.1016/s0040-4020(99)00703-6

专利信息

专利号:US-8389703-B1
优先权日:2004-08-28
标 题 :Ribonucleoside analogs with novel hydrogen bonding patterns
发明人：BENNER STEVEN A; KIM HYO-JOONG
权利人:BENNER STEVEN A; KIM HYO-JOONG
摘要:This invention relates to nucleoside, nucleotide, and oligonucleotide analogs that incorporate non-standard nucleobase analogs, defined to be those that present a pattern of hydrogen bonds to a paired nucleobase analog in a complementary strand that is different from the pattern presented by adenine, guanine, cytosine, and thymine. The invention is specifically concerned with nucleotide analogs that present the donor-donor-acceptor, hydrogen bonding patterns on pyrimidine analogs, and especially those that are analogs of ribonucleotides, including protected ribonucleotides suitable for phosphoramidite-based synthesis of RNA. The heterocycles on these nucleoside analogs are aminopyridones that have electron withdrawing groups attached to the position analogous to the 5-position of the ring in standard pyrimidines, including nitro, cyano, and carboxylic acid derivatives.