CAS: 43229-70-5; N,O-Dibenzylated Formoterol

主要参考文献

参考标题: Process For The Synthesis Of Arformoterol Processus Pour La Synthèse D'Arformotérol
摘要:The Present Invention Provides A Process For Preparing A Compound Of Formula (Vl) Or A Salt Thereof, The Process Comprising: (I) Reacting 4-Methoxyphenyl Acetone With An Amine Of Formula (Viii) Under Conditions Of Reductive Amination To Produce A Compound Of Formula (II) Or A Salt Thereof, Wherein There Is No Isolation Of An Imine Intermediate Formed During The Reductive Amination; (II) Condensing The Compound (II) Or The Acid Addition Salt Thereof With An α-Haloketone Of Formula (III) To Produce The Compound Of Formula (Iv); (III) Reducing The Compound (Iv) To A Compound Of Formula (V); And (Iv) Reducing The Compound (V) To The Compound Of Formula (Vl), Wherein The Reduction Is Carried Out In The Presence Of Either (1 ) A Hydrogen Donating Compound In The Presence Of A Hydrogen Transfer Catalyst; Or (2) Ammonium Formate Using A Hydrogenation Catalyst, Wherein: R1 And R2 Are Independently Optionally Substituted Arylalkyl, And Hal Is Selected From Chloro Or Bromo.