CAS: 501-81-5; 3-Pyridineacetic Acid

该化合物是一种芳烃式的碳酸,其特征为三点方位,以状环替换为乙酸组,该化合物一般是白色的白白晶状固体,可溶于水中,反映其极性,由于氨酸功能组,该物质在水中具有极性.该物质具有C7H7NO2分子分子配方,其分子重量与其结构相对应.环的存在具有基本特性,使其得以参与各种化学反应,包括酯化和恐吓.3-Pyridianeaterather酸对医药化学感兴趣,并可能展示生物活动,使其成为药用研究的课题.还可以探索其衍生物,用于农业化学品和有机合成的中间体.安全数据表明,与许多有机酸一样,在处理时应当小心避免皮肤和眼睛受到刺激.

结构式图片

相似化合物

6419-36-9 6419-36-9 39931-77-6

欧盟法规

REACH注册ECHA物质C&L通报REACH预注册

上下游产品

CAS号6419-36-9 3-吡啶乙酸盐酸盐 | CAS号5423-64-3 Morpholine, 4- ... | CAS号490-75-5 高奎宁酸 | CAS号6443-85-2 3-吡啶基乙腈 | CAS号626-55-1 3-溴吡啶 | CAS号39931-77-6 3-吡啶基乙酸乙酯 | CAS号39998-25-9 (吡啶-3-基)乙酸甲酯 | CAS号350-03-8 3-乙酰吡啶 | CAS号81335-71-9 2-Pyridinecarbo... | CAS号807361-96-2 (2-methoxycarbo... | CAS号3724-16-1 吡啶-3-乙酰胺 | CAS号39998-25-9 (吡啶-3-基)乙酸甲酯 | CAS号500-22-1 吡啶-3-甲醛 | CAS号19690-13-2 倍他司汀 | CAS号98-92-0 烟酰胺 | CAS号108-99-6 3-甲基吡啶 | CAS号86827-10-3 N-Cbz-3-哌啶乙酸 | CAS号74494-52-3 3-哌啶乙酸 | CAS号6302-03-0 3-乙酰丙酮 | CAS号71271-61-9 1-甲基-2-(3-吡啶基)乙胺

合成工艺路线路线简述

  • 合成目标产物 3-Pyridylacetic Acid 主要起始原料 3-Pyridylacetic Acid Hydrochloride
  • (文献来源)合成步骤主要原料 3-Pyridylacetic Acid Hydrochloride
甲基3-(氯甲酰基)-2-吡啶羧酸酯置于sodium Hydroxide,二氯甲烷,N,N-二甲基苯胺,Silver(L) Oxide体系中,化学反应生成 3-吡啶乙酸
参考文献:可以用3-重氮乙酰基吡啶和新型umwandlungsprodukte替代.β-同源-胆甾醇和β-同源烟碱
标题:可以用3-重氮乙酰基吡啶和新型umwandlungsprodukte替代.β-同源-胆甾醇和β-同源烟碱
摘要:
DOI:10.1002/hlca.194102401174

海关参考信息

专利信息


专利号:US-7612229-B2
优先权日:2003-01-28
标 题:Industrial process for the synthesis of 2-substituted 1-(hydroxy-ethylidene)-1,1-bisphosfi- conic acids of high purity and the salts thereof
发明人:NEU JOZSEF; FISCHER JANOS; FODOR TAMAS; TOERLEY JOZSEF; GIZUR TIBOR; LEVAI SANDOR; DEMETER ADAM; PERENYI EVA
权利人:RICHTER GEDEON VEGYESZET
摘要:Process for the synthesis of high purity 2-substituted-1-(hydroxy-ethylidene)-1,1-bisphosphonic acid of formula (I), the salts and hydrates thereof—wherein the meaning of R is 3′-pyridyl or 2′-amino-ethylidene group—from compounds of formula (II)—wherein the meaning of R is as described above—or salts and hydrates thereof with phosphorous acid in the presence of methanesulfonic acid using phosphorus pentoxide as reagent and in given case the obtained acid is converted into a salt with base.

专利号:US-2025091989-A1
优先权日:2023-09-19
标 题 :Small molecule protein synthesis modulators
发明人:GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:US-7109377-B2
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
发明人:SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
权利人:HARVARD COLLEGE
摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

专利号:US-9982005-B2
优先权日:2013-04-04
标 题 :Macrolides and methods of their preparation and use
发明人:MYERS ANDREW G; SEIPLE IAN BASS; ZHANG ZIYANG
权利人:HARVARD COLLEGE
摘要:Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides. Intermediates in the synthesis of macrolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are also provided. A general diastereoselective aldol methodology used in the synthesis of the western half is further provided.

专利号:US-7321044-B2
优先权日:2001-10-12
标题 :Synthesis of oxygen-substituted benzocycloheptenes as valuable intermediate products for the production of tissue-selective estrogens
发明人:PLATZEK JOHANNES; BECKMANN WOLFGANG; GEISLER JENS; KIRSTEIN HOLGER; NIEDBALLA ULRICH; OTTOW ECKHARD; RADAU SIGMAR; SCHULZ CLAUDIA; WESSA THOMAS
权利人:SCHERING AG
摘要:The invention relates to intermediate products and a new process for the production of benzocycloheptene C. n n n n n n n n n n The process for the production of its new intermediate products according to the invention starts from economical starting materials, provides the intermediate stages in high yields and high purity, without chromatographic purification steps, and allows production on an industrial scale.

专利号:US-6177572-B1
优先权日:1997-08-20
标题 :Solid and liquid-phase synthesis of benzoxazoles and benzothiazoles and their use
发明人:WANG FENGJIANG
权利人:SEPRACOR INC
摘要:Methods for preparing benzoxazoles and benzothiazoles on solid supports. Substituted benzothiazoles and benzoxazoles, libraries of the compounds, and methods of using the compounds are also disclosed.
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主要参考文献

[参考文献]: Ginoulhiac E, Et Al. 3-Pyridineacetic Acid And Nicotinic Acid: Blood Levels, Urinary Elimination And Excretion Of Nicotinic Acid Derivatives In Man. Nature. 1962 Mar 10;193:948-9.
[参考文献]: Zwickenpflug W, Et Al. Metabolism Of Myosmine In Wistar Rats. Drug Metab Dispos. 2005 Nov;33(11):1648-56.

合成参考文献


摘要:Mérour, J.-Y.; Joseph, B., Science of Synthesis Knowledge Updates, (2016) 3, 414.
摘要:Cheng, B.; Wang, T., Science of Synthesis Knowledge Updates, (2020) 3, 154.
摘要:Hutskalova, V.; Sparr, C., Science of Synthesis Knowledge Updates, (2022) 1, 29.
摘要:Schafer, E. W., Jr., and W. A. Bowles Jr. 1985. Acute oral toxicity and repellency of 933 chemicals to house and deer mice. Archives of Environmental Contamination and Toxicology 14:111-129.
摘要:Schafer, E. W., Jr., and W. A. Bowles Jr. 2004. Toxicity, Repellency of Phytotoxicity of 979 Chemicals to Birds, Mammals and Plants. Research Report No. 04-01. National Wildlife Research Center, Fort Collins, Colorado. 118 pp. https://www.aphis.usda.gov/ws/nwrc/chem-effects-db/U_schafer041_2004.pdf
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