CAS: 536-60-7; (4-Isopropylphenyl)Methanol

该化合物是一种多用途芳香醇,配有分子配方C10H14O.它有一个以异丙基组替代的苯基酒精结构,其位置在准位置上,它增强了有机合成中的溶性与回活性.该化合物通常因其稳定的芳香脊椎和功能性氢氧基组而被用作中间体,其中度极性和挥发性使它适合用于需要受控再活性的配方.异丙基组有助于产生消毒效应,影响合成途径的选择性.建议适当处理,如同所有苯基酒精衍生物一样,确保实验室和工业应用的安全.

结构式图片

相似化合物

122-03-2 536-66-3 20185-55-1

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

formaldehyd 4-isopropylphenylmagnesium bromide p-isopropylbenzoic acid methyl ester (4-isopropylbenzyl)magnesium chloride 4-(i-propyl)benzyl acetate 4-nitro-benzoic acid-(4-isopropyl-benzyl ester) phenyl-acetic acid-(4-isopropyl-benzyl ester) nonanedioic acid bis-(4-isopropyl-benzyl ester)

合成工艺路线路线简述

  • 合成目标产物 4-Isopropylbenzyl Alcohol 主要起始原料 Cuminaldehyde
  • (文献来源)合成步骤主要原料 Cuminaldehyde
4-异丙基苯甲酸置于lithium Aluminium Tetrahydride体系中,化学反应生成 4-异丙基苯甲醇
参考文献:Pritzkow,Wilhelm; Thomas,Gerda; Willecke,Lothar,Journal Fur Praktische Chemie (Leipzig 1954),1985,Vol. 327,# 5,P. 847-851
标题:Pritzkow,Wilhelm; Thomas,Gerda; Willecke,Lothar,Journal Fur Praktische Chemie (Leipzig 1954),1985,Vol. 327,# 5,P. 847-851

海关参考信息

专利信息


专利号:US-6172226-B1
优先权日:1993-12-22
标 题:Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions
发明人:COULL JAMES M; EGHOLM MICHAEL; HODGE RICHARD P; ISMAIL MOHAMED; RAJUR S B
权利人:PERSEPTIVE BIOSYSTEMS INC
摘要:A method is disclosed for preparing novel PNA synthons having protecting groups capable of removal under mild conditions. The PNA synthons are prepared by coupling novel N-substituted nucleobase intermediates having carbamate protection of the exocyclic amino group of the heterocycle to an amino protected backbone or an amino protected backbone ester of the amino acid N-(2-aminoethyl)-glycine. By the method of this invention, the resultant PNA synthons can have orthogonal protection of the carbamate protected nucleobase and the amino protected backbone. The PNA synthons are useful in the synthesis of peptide nucleic acids (PNAs) and other oligomers such as PNA-DNA chimeras, and may be used in automated synthesizers. Novel compositions of matter are also disclosed. In addition, a guanine PNA synthon having selective carbamate protection of the exocyclic 2-amino group with the C6 carbonyl group unprotected is disclosed.

专利号:US-8106031-B2
优先权日:2006-05-02
标题:Hydrolytically-resistant boron-containing therapeutics and methods of use
发明人:LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A
权利人:LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A; ANACOR PHARMACEUTICALS INC
摘要:Compositions and methods of use of boron derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by fungi, yeast, bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.

专利号:US-9765044-B2
优先权日:2013-03-15
标 题 :Synthesis of novel ionic liquids from lignin-derived compounds
发明人:SOCHA AARON; SINGH SEEMA; SIMMONS BLAKE A; BERGERON MAXIME
权利人:UNIV CALIFORNIA; SANDIA CORP
摘要:Methods and compositions are provided for synthesizing ionic liquids from lignin derived compounds comprising: contacting a starting material comprising lignin with a depolymerization agent to depolymerize the lignin and form a mixture of aldehyde containing compounds; contacting the mixture of aldehyde containing compounds with an amine under conditions suitable to convert the mixture of aldehyde containing compounds to a mixture of amine containing compounds; and contacting the mixture of amine containing compounds with an acid under conditions suitable to form an ammonium salt, thereby preparing the ionic liquid.

专利号:US-8742045-B2
优先权日:2009-06-03
标题:Polymerization initiator for living radical polymerization
发明人:GOTO ATSUSHI; KIM JEONG SIK; TSUJII YOSHINOBU; FUKUDA TAKESHI
权利人:GOTO ATSUSHI; KIM JEONG SIK; TSUJII YOSHINOBU; FUKUDA TAKESHI; UNIV KYOTO
摘要:Provided is a method of living radical polymerization which does not necessitate complicated and intricate synthesis of a dormant species and which is highly efficient. A halogenated derivative compound is used as a dormant species for initiating living radical polymerization. The derivative compound is obtained by halogenating an alcohol compound having a non-conjugated structure or an amine compound having a non-conjugated structure with a halogenating agent capable of halogenating an alcohol or amine. A radical produced by elimination of halogen from the halogenated derivative compound is allowed to react with the unsaturated bond of the monomer. Thus, the monomer, which has a radical-reactive unsaturated bond, is polymerized by living radical polymerization. Preferably, the halogenating agent is a compound (NIS or the like) which also has a function as a catalyst.

专利号:US-5288882-A
优先权日:1992-12-21
标题:Process for recovering an optically active epoxy alcohol
发明人:SHIH T THOMAS; SHUM WILFRED P-S
权利人:ARCO CHEM TECH
摘要:A method of recovering optically active epoxy alcohols from asymmetric epoxidation reaction mixture is provided whereby the epoxy alcohol may be obtained in high yield with minimal degradation of optical purity. The process is also suitable for the synthesis of useful organic sulfonate derivatives of chiral epoxy alcohols.

专利号:US-7612064-B2
优先权日:2003-05-26
标题:Sulfopyrroles
发明人:EBERLE MARTIN; ERMERT PHILIPP; OBRECHT DANIEL; LACH FRANK; LUTHER ANATOL; BACHMANN FELIX; STREBEL ALLESSANDRO
权利人:TAKEDA PHARMACEUTICAL
摘要:The invention relates to compounds of formula (I) wherein R 1 represents aryl, aralkyl or heteroaryl, R 2 is aryl or heteroaryl and R 3 is aryl, heteroaryl or optionally substituted aminomethyl, to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I), to the use of a compounds of formula (I) for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using compounds of formula (I) or of pharmaceutical compositions containing same.
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主要参考文献

[参考文献]: Wang B, Et Al. Essential Oils And Ethanol Extract From Camellia Nitidissima And Evaluation Of Their Biologicalactivity. J Food Sci Technol. 2018 Dec;55(12):5075-5081.
[参考文献]: Annemieke Strijkstra, Et Al. Anaerobic Activation Of P-Cymene In Denitrifying Betaproteobacteria: Methyl Group Hydroxylation Versus Addition To Fumarate. Appl Environ Microbiol. 2014 Dec;80(24):7592-603.

合成参考文献


参考文献:10.1007/s002030050784
摘要:Harms G, Rabus R, Widdel F. Anaerobic oxidation of the aromatic plant hydrocarbon p-cymene by newly isolated denitrifying bacteria. Arch Microbiol. 1999 Nov;172(5):303–12. doi: 10.1007/s002030050784.
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