2-氨基-2-苯乙酸乙酯置于sodium Tetrahydroborate体系中,用 乙醇,水 作为反应溶剂,化学反应生成 D-苯甘氨醇 参考文献:ber Die Stereoselektivitt Der 9,9-Spirobifluoren-Kronenther Gegenber-Aminoalkoholen 标题:ber Die Stereoselektivitt Der 9,9-Spirobifluoren-Kronenther Gegenber-Aminoalkoholen 摘要:Stereoselectivity Of 9,9'‐spirobifluorene Crown Ethers Towards α‐amino Alcoholscrown Ethers I‐vi Were Tested By Partition Experiments For Their Stereoselectivity Towards α‐amino Alcohols 1-10. The Stereoselectivity Depends In A Regular Way On Both The Absolute And Relative Configuration Of The Crown Ether And α‐aminoalcohol. Comments Are Made On Some High Stereoselectivities. DOI:10.1002/hlca.19830660738
专利号:US-7323575-B2 优先权日:2003-04-09 标题:Process for the synthesis of (2S)-indoline-2-carboxylic acid 发明人:SOUVIE JEAN-CLAUDE; LECOUVE JEAN-PIERRE 权利人:SERVIER LAB 摘要:Process for the synthesis of (2S)-indoline-2-carboxylic acid of formula (I): n nApplication in the synthesis of perindopril and its pharmaceutically acceptable salts.
专利号:US-10927135-B2 优先权日:2017-08-03 标 题:Metal-free direct arylation of dialkyl phosphonates for the synthesis of mixed alkyl aryl phosphonates 发明人:KANG JUN YONG; HUANG HAI 权利人:THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIV OF NEVADA LAS VE 摘要:Provided herein are phosphates, thiophosphates, phosphonates, and phosphinates, methods of making same, and methods of using these compounds and methods for the generation of pharmaceutically relevant phosphate, phosphonate, and phosphinate analogs. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
专利号:US-9988488-B2 优先权日:2013-03-26 标 题:Catalyst for poly(lactide) synthesis and uses thereof 发明人:CHAKRABORTY DEBASHIS; GHOSH SWARUP; RAMKUMAR VENKATACHALAM 权利人:INDIAN INSTITUTE OF TECH MADRAS 摘要:A catalysts for poly(lactide) synthesis having the structure of Formula I: n nwherein R 1 and R 2 is, independently, C 1 -C 6 alkoxy, and R 3 arylalkyl or substituted phenyl are disclosed. Method of synthesizing the catalysts and method of using the catalysts to prepare poly(lactides) and compositions comprising the catalyst are also disclosed.
专利号:US-11873315-B2 优先权日:2017-06-16 标 题 :Chiral n-heterocyclic phosphorodiamidic acids (NHPAS) and derivatives as novel Brønsted acid catalysts 发明人:KANG JUN YONG; HUANG HAI 权利人:The Board of Regents of the Nevada System of Higher Education on Behalf of the Univ of Nevada; THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIV OF NEVADA LAS VE 摘要:Provided herein are diaryl and arylalkyl phosphonates, useful as intermediates in, for example, the synthesis of leukocyte elastase inhibitors, potassium channel modulators, chemiluminescence materials, and flame retardants, and methods for making same. Also provided are N-heterocyclic phosphorodiamidic acids (NHPAs) useful in reactions such as, for example, in the preparation of diaryl and arylalkyl phosphonates. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
专利号:US-2001047100-A1 优先权日:2000-04-26 标 题:Chiral imidazoyl intermediates for the synthesis of 2-(4-imidazoyl)-cyclopropyl derivatives 发明人:KJAERSGAARD HANS JOERGEN; PHILLIPS JIM; ALI SYED M 摘要:Novel intermediates useful in the preparation of optically active H 3 histamine receptor antagonist 2-(4-imidazoyl)-cyclopropyl derivatives are disclosed.
专利号:US-6235871-B1 优先权日:1997-12-03 标题:Synthesis of oligoarylamines, and uses and reagents related thereto 发明人:SINGER ROBERT A; SADIGHI JOSEPH P; BUCHWALD STEPHEN L; MACKEWITZ THOMAS 权利人:MASSACHUSETTS INST TECHNOLOGY 摘要:The transition metal-catalyzed amination of aryl halides, in conjunction with an orthogonal protective group scheme, forms the basis of two routes to oligoaniline precursors. The oligoaniline precursors are soluble in a variety of common organic solvents, and are easily converted to the deprotected oligoanilines. The method allows the preparation of oligoanilines of even or odd chain lengths, and the incorporation of a variety of functional groups into the oligomers. Polyanilines of low polydispersity can also be prepared by this method.
[参考文献]: Grégory Chaume, Et Al. Straightforward Synthesis Of (S)- And (R)-Alpha-Trifluoromethyl Proline From Chiral Oxazolidines Derived From Ethyl Trifluoropyruvate. Org Lett. 2006 Dec 21;8(26):6123-6.
合成参考文献
摘要:Tomé, A. C., Science of Synthesis Knowledge Updates, (2015) 2, 84. 摘要:Barsegyan, Y. A.; Vil’, V. A.; Tomkinson, N. C. O.; Terent’ev, A. O., Science of Synthesis Knowledge Updates, (2022) 1, 263. 摘要:Fleischer, I.; Mejía, E., Science of Synthesis: C-1 Building Blocks in Organic Synthesis, (2013) 1, 125. 摘要:Simon, R. C.; Busto, E.; Fischereder, E.-M.; Fuchs, C. S.; Pressnitz, D.; Richter, N.; Kroutil, W., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 2, 398. 摘要:Treacy, S. M.; Zhang, X.; Rovis, T., Science of Synthesis, (2021) , 627.