CAS: 618-94-0; 3-Nitrobenzhydrazide

该化合物其结构特征为在苯环上的氢氮(-NO2)组的元体位置上的硝基(-NO2).3-Nitrobenhnhydazide因其在有机合成中的应用而著称,特别是用作各种六环化合物的再试剂和合成药物的中间体,在水和乙醇等极溶剂中表现出中等溶性,在标准条件下一般稳定.然而,与许多硝基化合物一样,它可能构成某些危害,包括潜在的毒性和环境关切,需要谨慎处理和处置.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号618-95-1 3-硝基苯甲酸甲酯 | CAS号618-98-4 间硝基苯甲酸乙酯 | CAS号121-92-6 间硝基苯甲酸 | CAS号610-34-4 2-硝基苯甲酸乙酯 | CAS号121-90-4 间硝基苯甲酰氯 | CAS号105686-75-7 4-amino-3-(3-ni... | CAS号5378-35-8 3-[1,3,4]噁二唑-2-苯胺 | CAS号2000-54-6 Urea,N-(3-nitro... | CAS号99-61-6 间硝基苯甲醛 | CAS号78-98-8 丙酮醛 | CAS号35219-13-7 4-(1,3,4-噁二唑-2-基)苯胺 | CAS号261623-52-3 n'-(2,2-dimethy... | CAS号2588-85-4 3-[5-(3-aminoph... | CAS号618-95-1 3-硝基苯甲酸甲酯

合成工艺路线路线简述

  • 合成目标产物 3-Nitrobenzhydrazide 主要起始原料 Methyl 3-Nitrobenzoate
  • (文献来源)合成步骤主要原料 Methyl 3-Nitrobenzoate

海关参考信息

专利信息


专利号:US-5478947-A
优先权日:1994-07-29
标题 :Effective process for the production of 1,2,3-triazoles
发明人:SINGH INDER P; SPEVAK PAUL; PALAK BHUPINDER; AMEDJO SAMUEL; MICETICH RONALD J
权利人:SYNPHAR LAB INC
摘要:A high purity triazole is obtained by the reaction of a hydrazide of the general formula II and glyoxal followed by the treatment of the intermediate of general formula IV with ammonia. The total process is done in one pot and does not require the isolation of the intermediate IV. The triazole (I) is isolated by distillation. Synthesis of various N 1 -substituted triazoles is also described following the same procedure.

专利号:US-6291504-B1
优先权日:1999-10-20
标题:Acylsemicarbazides and their uses
发明人:NUGIEL DAVID A; CARINI DAVID J; DI MEO SUSAN V; VIDWANS ANUP P; YUE EDDY W
权利人:DU PONT PHARM CO
摘要:The present invention relates to the synthesis of a new lass of indeno[1,2-c]pyrazol-4-ones of formula (I):that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-9 and their regulatory subunits know as cyclins A-H.This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

专利号:US-5527920-A
优先权日:1994-11-18
标 题:Economical manufacturing process for 1,2,3-triazoles
发明人:SINGH INDER P; SPEVAK PAUL; PALAK BHUPINDER; AMEDJO SAMUEL; MICETICH RONALD G
摘要:A high quality 1,2,3-triazole is obtained in a one pot two step reaction between appropriately substituted hydrazide derivatives, dihaloethanediol and NH 3 in methanol. Synthesis of various N 1 -alkyl, N 1 -aryl, and N 1 -heterocyclic-1,2,3-triazoles is also accomplished following the same general procedure.

专利号:CN-102285935-A
优先权日:2011-08-02
标 题:Synthesis of 2,2'-(1,3-phenylene)bis{5-[4-(1,1-dimethylethyl)phenyl]}-1,3,4-oxadiazole

专利号:WO-0234721-A1
优先权日:2000-10-20
标 题:Acylsemicarbazides and their use as cyclin dependent kinase (cdk) inhibitors
发明人:NUGIEL DAVID A; CARINI DAVID J; DI MEO SUSAN V; VIDWANS ANUP; YUE EDDY W
权利人:DU PONT PHARM CO
摘要:The present invention realtes to the synthesis fo a new class of indeno [1,2-c]pyrazol-4-ones of formula (I): that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-9 and their regulatory subunits know as cyclins A-H. The invention also provides a novel method of treating cancer or otehr profiferative disease by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative disease by administering a therapeutically effective combination of one of the compounds of teh present invention and one or more other known anti-cancer or anti-proliferative agents.

专利号:US-6613942-B1
优先权日:1997-07-01
标题 :Glucagon antagonists/inverse agonists
发明人:LING ANTHONY; GREGOR VLAD; GONZALEZ JAVIER; HONG YUFENG; KIEL DAN; KUKI ATSUO; SHI SHENGHUA; NAERUM LARS; MADSEN PETER; SAMS CHRISTIAN; LAU JESPER; PLEWE MICHAEL BRUNO; FENG JUN; TENG MIN; JOHNSON MICHAEL DAVID; TESTON KIMBERLY ANN; SIDELMANN ULLA GROVE; KNUDSEN LOTTE BJERRE
权利人:NOVO NORDISK AS
摘要:Non-peptide compounds comprising a central hydrazide motif and methods for the synthesis thereof are disclosed. The compounds act to antagonize the action of the glucagon peptide hormone.
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主要参考文献

参考标题:Studies In The Triazine Series Including A New Synthesis Of 1:2:4-Triazines
作者:P.V. Laakso,R. Robinson,H.P. Vandrewala |发布日期:1957.1
摘要:Mono-Aroylhydrazones Of Benzil Are Cyclised By Ammonium Acetate In Hot Acetic Acid To Tri-Substituted-1:2:4-Triazines. The Yield Is Favourable And It Is Not Necessary, Or Even Advantageous, To Isolate The Presumed Intermediates. The New Synthesis Has Been Applied To A Sufficient Range Of Examples To Establish Its Status As A General Method. In The Case Of Phenanthraquinone The Reaction Took A More Complex Course And

合成参考文献


摘要:Aggarwal, P.; Bebbington, M. W. P., Science of Synthesis Knowledge Updates, (2012) 2, 402.
摘要:E. V. Titov, L. M. Kapkan, V. I. Rybachenko and N. G. Korzhenevskaya, Org. React. (USSR) 5, 273 (1968).
参考文献:10.1107/s1600536810049470
摘要:Mao FL, Dai CH. (E)-N'-(2,4-Dichloro-benzyl-idene)-3-nitro-benzohydrazide. Acta Crystallogr Sect E Struct Rep Online. 2010 Nov 30;66(Pt 12):o3360.
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