CAS: 6790-09-6; 3,6,9,12,15,18,21,24,27,30,33-Undecaoxapentatriacontane-1,35-Diol

相似化合物

2050595-03-2 112-27-6 1050500-41-8

上下游产品

CAS号37860-51-8 四乙二醇二对甲苯磺酸酯 | CAS号112-60-7 三缩四乙二醇 | CAS号86259-87-2 四甘醇单苄醚 | CAS号89346-82-7 四乙二醇单苄醚对甲苯磺酸酯 | CAS号5117-19-1 八乙二醇 | CAS号57436-38-1 Tos-PEG8-Tos | CAS号26150-06-1 Acryloyl-PEG4-OH | CAS号112-27-6 三甘醇

二乙二醇单甲醚置于palladium 10% On Activated Carbon,Potassium Tert-Butylate,氢气,Sodium Hydroxide体系中,用 四氢呋喃,乙醇,水 作为反应溶剂,20.0 °C,2.0 Mpa 条件下,反应 35.5H,反应生成 十二聚乙二醇
参考文献:接近单分散性的聚环氧乙烷的合成
标题:接近单分散性的聚环氧乙烷的合成
摘要:聚合物中的多分散性妨碍了对其结构-性质关系的基本了解,并阻碍了它们在医学等领域使用,因为多分散性会影响生物活性.相对短链的聚环氧乙烷[(ch 2 CH2O 2)n的多分散性; [peo]影响其生物学活性,例如,Peo酰化药物的毒性和功效.结果,已经进行了巨大的努力以尽可能降低分散度(不可能真正地单分散的材料).在这里,我们报告了一种合成程序,该程序导致了前所未有的低分散度.我们还首次表明,可以区分只有一个环氧乙烷(eo)单元不同的peo,这对于验证此处实现的极低分散度至关重要.预计接近单分散性的聚环氧乙烷的合成将在许多应用中对摩尔质量的分布敏感的领域中具有价值.
DOI:10.1002/anie.201403436

专利信息

专利号:US-2023111600-A1
优先权日:2019-12-17
标题 :Polymeric fatty acid compounds for the treatment of fibrous amino acid-based substrates, especially hair
发明人：WAGNER ROLAND; STREICHER KATHARINA; ROHMANN LAURA; WENSKE CHRISTIAN; HAVELI SHRUTISAGAR DATTATRAYA
权利人:MOMENTIVE PERFORMANCE MAT GMBH
摘要:The present invention is directed at mono-, di- or polyquaternary ammonium compounds of the formula (I) wherein x is 1 to 50, and F can be the same or different and is represented by the general formula (II) wherein at least one of the optionally substituted and optionally functional-group-containing hydrocarbon radicals R 1 , R 2 , R 3 , R 4 or R 5 contains at least one estolide moiety comprising two or more ester or amide moieties. The invention also relates to a process for the synthesis of such compounds, the use of the compounds in cosmetic formulations for skin and hair care, cosmetic compositions for the treatment of fibers, and compositions containing one or more of the compounds for the treatment of hair.

专利号:US-2022265691-A1
优先权日:2019-07-12
标 题 :Methods for use of gene expression as an indicator of e-selectin inhibitor efficacy and clinical outcome for multiple tumor types
发明人：MAGNANI JOHN L; FOGLER WILLIAM E; THACKRAY HELEN M; FELDMAN ERIC J; STEWART DAVID
权利人:GLYCOMIMETICS INC
摘要:Cancer patients that express high levels of the E-selectin ligand (sialyl Lea/x) on their tumors have a poorer outcome. Interestingly, relapsed/refractory acute myeloid leukemia (AML) patients expressing high levels of sialyl Lex on their blasts show the greatest therapeutic response when treated with the E-selection inhibitor compound of Formula I. Transcriptome profiling of E-selectin ligand-forming glycosylation genes showed that ST3GAL4 and FUT7 were consistently expressed in the majority of cancers evaluated. Poor survival outcomes of FLT3-mutated AML patients that express high levels of ST3GAL4 and FUT7 implicated E-selectin in this disease state. These genes may be predictive biomarkers in AML patients. Methods of treatment of cancer comprising screening AML patients for expression of genes that contribute to the synthesis of the E-selectin ligand sialyl Lex, then treating those patients with an E-selection inhibitor, are disclosed.

专利号:US-12036300-B2
优先权日:2021-03-31
标题:Methods and compositions for improving skin
发明人：LIAO I-CHIEN; BRIEVA PATRICIA; JUCHAUX FRANCK; BOUEZ CHARBEL; ZHENG QIAN; QIAN KUN
权利人:OREAL
摘要:A method for managing skin tone comprising reducing the synthesis of melanin by applying a skin treatment composition to skin. The skin treatment composition may include about 0.1 to about 25 wt. % of acetyl trifluoromethylphenyl valylglycine; about 0.5 to about 30 wt. % of a polyol; about 0.1 to about 30 wt. % of a silicone, fatty compound, or a mixtures thereof, wherein the skin treatment composition is an emulsion, and all weight percentages are based on the total weight of the skin treatment composition.

专利号:US-2022047711-A1
优先权日:2018-12-10
标题 :Photocrosslinking peptides for site specific conjugation to fc-containing proteins
发明人：SADOWSKY JACK; ZACHARIAS NEELIE TYANA
权利人:GENENTECH INC
摘要:Provided herein are peptides having a photocrosslinking moiety useful for the synthesis of antibody-drug conjugates as well as methods of making and using such conjugates.

专利号:CN-115925790-A
优先权日:2016-03-23
标 题:Method for the synthesis of α4β7 peptide antagonists

专利号:US-2011040113-A1
优先权日:2009-06-02
标 题 :Pure PEG-lipid conjugates
发明人：WU NIAN; KELLER BRIAN CHARLES
权利人:WU NIAN; KELLER BRIAN CHARLES
摘要:Syntheses of polyethyleneglycol (PEG)-lipid conjugates are disclosed. Such syntheses involve stepwise addition of small PEG oligomers to a glycerol backbone until the desired chain size is attained. Polymers resulting from the syntheses are highly monodisperse. The present invention provides several advantages such as simplified synthesis, high product yield and low cost for starting materials. The present synthesis method is suitable for preparing a wide range of conjugates. n In another aspect, the invention comprises PEG lipid conjugates having a glycerol backbone covalently attached to one or two monodisperse PEG chains and one or two lipids. These conjugates are especially useful for pharmaceutical formulations.