CAS: 3081-61-6; (S)-2-Amino-5-(Ethylamino)-5-Oxopentanoic Acid

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上下游产品

CAS号75-04-7 乙胺 | CAS号138036-14-3 2-(1,3-dioxo-1,... | CAS号56-86-0 L-谷氨酸 | CAS号593-51-1 一甲胺盐酸盐 | CAS号56-85-9 L-谷氨酰胺 | CAS号557-66-4 乙胺盐酸盐 | CAS号1499-55-4 L-谷氨酸-5-甲酯 | CAS号142-47-2 谷氨酸钠 | CAS号56-86-0 L-谷氨酸 | CAS号75-04-7 乙胺

Z-L-Theanine置于20% Palladium Hydroxide-Activated Charcoal,氢气体系中,用 四氢呋喃 作为反应溶剂,化学反应 8.0H,以100%的收率获得产物茶氨酸
参考文献:L-茶氨酸对海马神经元兴奋作用的表征:基于其骨干的新型n-甲基-D-天冬氨酸受体调节剂的产生
标题:L-茶氨酸对海马神经元兴奋作用的表征:基于其骨干的新型n-甲基-D-天冬氨酸受体调节剂的产生
摘要:L-茶氨酸(或l-γ-N-乙基-谷氨酰胺)是山茶中发现的主要氨基酸.由于其多效性的生理和药理活性特别是对人类健康有益,因此受到了广泛的关注.在这里,我们描述了一个新的,方便,高效和环境友好的化学合成升-Theanine和升-γ-ñ丙基谷氨酰胺和它们对应的d异构体.到目前为止,L-茶氨酸及其衍生物在n-甲基-D处表现出部分拮抗作用.-天冬氨酸(nmda)受体,对培养的海马神经元没有其他谷氨酸受体的激动作用.该活性保留在非洲爪蟾卵母细胞中表达的nmda受体上.另外,含有1-甲基茶氨酸的nmda受体的glun2A和glun2B均被1-茶氨酸同样地调节.如在培养的海马神经元上所测量的,从1-茶氨酸到d-茶氨酸的立体化学变化以及乙基取代1-和d-茶氨酸的γ-N位置上的丙基部分显着增强了生物学功效.升因此,-茶氨酸结构代表了开发新型nmda受体调节剂的有趣骨架.
DOI:10.1021/acschemneuro.7B00036

专利信息

专利号:US-2022098155-A1
优先权日:2018-11-14
标 题 :Novel pathway for the synthesis of diazirines, that may or may not be enriched in nitrogen-15
发明人：REBOUL VINCENT; FRANCK XAVIER; GLACHET THOMAS; MARZAG HAMID
权利人:UNIV ROUEN NORMANDIE; UNIV CAEN; INSTITUT NAT DES SCIENCES APPLIQUEES DE ROUEN INSA; CENTRE NAT RECH SCIENT; ECOLE NAT SUPERIEURE DINGENIEURS DE CAEN
摘要:The present invention concerns a novel method for synthesising diazirines, that may or may not be enriched in nitro-gen-15, from amino acids or imines, via a one-pot synthesis method, comprising the reaction of the starting amino acid or imine with ammonia, which may or may not be enriched in nitrogen-15, and a hypervalent iodine oxidant. The present invention also relates to a method for synthesising ammonia enriched in nitrogen-15. The invention also concerns certain diazirines of formula (I) likely to be obtained by the claimed synthesis method, and also refers to the 15 N 2 -diazirines of formula (I′). The claimed diazirines can be used in photoaffinity labelling. The 15 N 2 -diazirines can also be used in hyperpolarisation, in particular in the medical imaging field.

专利号:US-9453037-B2
优先权日:2011-07-28
标 题 :Methylphenidate-prodrugs, processes of making and using the same
发明人：GUENTHER SVEN; CHI GUOCHEN; BERA BINDU; MICKLE TRAVIS; BERA SANJIB
权利人:KEMPHARM INC; KEMPHARM INC
摘要:The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.

专利号:WO-2007143886-A1
优先权日:2006-06-09
标题 :Improved synthesis method of l-theanine
发明人：CHEN XIN; WANG KAIWEN
权利人:NANJING RALLY BIOCHEMICAL INC; CHEN XIN; WANG KAIWEN
摘要:The invention provides an improved synthesis method of L-theanine, the process has optimized and easy-to-operate reaction conditions: the L-theanine is prepared by reacting L-pyrrolidone acid and anhydrous ethylamine with antioxidant existence and under the condition of eliminating air by dry ethylamine, and the reaction temperature is between 30-59 , and the reaction pressure is between 0.4-5.9 Mpa. The yield of L-theanine by the present method is obviously higher than that prepared without antioxidant and dry ethylamine to eliminate air.

专利号:CN-102533886-A
优先权日:2012-01-11
标题:Production process of biological solid-phase enzyme catalyzed synthesis of L-theanine

专利号:CN-117802125-A
优先权日:2023-12-29
标 题 :Gene related to synthesis of theanine from endosperm of crop seeds and application

专利号:CA-3119871-A1
优先权日:2018-11-14
标 题:Novel pathway for the synthesis of diazirines, that may or may not be enriched in nitrogen-15