专利号:US-11897827-B1 优先权日:2022-11-22 标 题 :Carbon isotope exchange mediated by vanadium complexes 发明人:BUKHRYAKOV KONSTANTIN 权利人:BUKHRYAKOV KONSTANTIN; THE FLORIDA INTERNATIONAL UNIV BOARD OF TRUSTEES 摘要:The subject invention provides catalytical compounds/complexes, compositions comprising such compound/complex, synthesis of the compounds/complexes, and methods of using such compounds/complexes as catalysts in, for example, carbon isotope exchange (CIE) on target bioactive molecules. Methods that allow CIE directly on drug candidates are of great importance to chemistry, biology, and medicine. Especially valuable are catalytic procedures that rely on a limited collection of available labeled materials. The instant method comprises converting a methyl group to terminal â•?CH2 utilizing transfer dehydrogenation catalysts to enable V-based olefin metathesis, followed by a hydrogenation step. The one-pot strategy allows the formal methylation/demethylation sequence and can be applied to an assortment of alkyl-containing compounds.
专利号:US-2004162274-A1 优先权日:2002-11-01 标题 :Inhibition of steroid synthesis by use of progesterone or a progesterone receptor agonist 发明人:PAUST HANS-JOACHIM; MUKHOPADHYAY AMAL K; PATCHEV VLADIMIR 摘要:The present invention relates to the use of progesterone or a progesterone receptor agonist for the inhibition of steroid synthesis, in particular for inhibiting the expression of the steroidogenic acute regulatory protein (StAR protein).
专利号:EP-1415653-A2 优先权日:2002-11-01 标 题:Use of progesterone or an agonist thereof for the inhibition of steroid synthesis
专利号:DE-10251028-A1 优先权日:2002-11-01 标题 :Use of progesterone or a progesterone receptor agonist to inhibit steroid synthesis
专利号:JP-2004155783-A 优先权日:2002-11-01 标题 :Inhibitor of steroid synthesis using progesterone or progesterone receptor agonist
专利号:RU-2175969-C2 优先权日:1995-11-06 标题:Derivatives of 1-arylsulfonyl-, arylcarbonyl- or arylthiocar- bonylpyridazine, method of their synthesis, pharmaceutical composition
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合成参考文献
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