CAS: 36394-75-9; (S)-(-)-2-Acetoxypropionylchloride

相似化合物

40635-66-3 13831-31-7 26404-20-6

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CAS号535-17-1 2-乙酰氧基丙酸 | CAS号79-37-8 草酰氯 | CAS号79-33-4 L-(+)-乳酸 | CAS号75-36-5 乙酰氯 | CAS号867-56-1 L-乳酸钠 | CAS号35000-37-4 (叔丁氧基羰基甲基)氯化三苯基磷

Sodium L-Lactate 反应生成2-过氧乙酰丙酰氯
参考文献:First Synthesis And Crystal Structures Of Chiral 1,3-Dienylborates
标题:First Synthesis And Crystal Structures Of Chiral 1,3-Dienylborates
摘要:We Report On The Synthesis Of Bicyclic 1,3-Dienylborates (1A/1B And 2A/2B),Wherein The Boron And Nitrogen Atoms Are Chiral. The Absolute Configuration Of These Molecules Was Established By Single X-Ray Diffraction Studies And Qualitative Homonuclear Noe Difference Spectroscopy. The Conformational Stability Of These Molecules Is Low At Ambient Or Subambient Temperature. The Diastereomeric Berates (2A/2B) Were Found To Be Very Reactive Toward Dienophiles In The Diels-Alder Reaction.
Doi:10.3987/com-98-S(H)60

专利信息

专利号:US-4937367-A
优先权日:1987-07-15
标 题:Process for the preparation of intermediates for the synthesis of fosfomycin
发明人：CASTALDI GRAZIANO; GIORDANO CLAUDIO
权利人:ZAMBON SPA
摘要:A process is described for the preparation of intermediates useful in the synthesis of Fosfomycin. n More particularly, an enantioselective process is described for the preparation of derivatives of (1S,2S)-1,2-dihydroxypropyl-phosphonic acid of formula ##STR1## wherein R 2 and R 3 have the meanings reported in the specification.

专利号:WO-2025073833-A1
优先权日:2023-10-04
标 题:Optimized process for the preparation of iopamidol
发明人：BUONSANTI FEDERICA; MAZZON ROBERTA; FRETTA ROBERTA
权利人:BRACCO IMAGING SPA
摘要:The present invention relates to the field of organic chemistry, in particular to the synthesis of iodinated contrast agents. More in particular, the invention relates to a sustainable process for the synthesis of iopamidol which allows to improve the purity profile of the product and avoids the use of potentially hazardous reagents and solvents.

专利号:US-10836711-B2
优先权日:2017-02-10
标 题 :Method for the one-pot production of organo-iodinated compounds
发明人：PETTA MYRIAM; PELLINGHELLI STEPHAN
权利人:GUERBET SA
摘要:The present invention concerns a process for the preparation of organo-iodized compounds, as well as their preparation intermediates. More particularly, the present invention concerns a process for the preparation of organo-iodized compounds which can be used as preparation intermediates in the synthesis of iodized contrast agents.

专利号:US-10836710-B2
优先权日:2016-12-05
标 题 :Mechanochemical synthesis of radiographic agents intermediates
发明人：BARGE ALESSANDRO; BARICCO FRANCESCA; CRAVOTTO GIANCARLO; FRETTA ROBERTA; LATTUADA LUCIANO
权利人:BRACCO IMAGING SPA
摘要:The present invention generally relates to a process using a mechanochemical approach exploiting the mechanical milling of reactants for the manufacturing of acetyl Iopamidol and, more generally, of key intermediates of radiographic contrast agents, and of the contrast agents themselves.

专利号:US-8754259-B2
优先权日:2008-08-15
标 题 :Synthesis of cyclohexane derivatives useful as sensates in consumer products
发明人：YELM KENNETH EDWARD; BUNKE GREGORY MARK; HAUGHT JOHN CHRISTIAN
权利人:PROCTER & GAMBLE; PROCTER & GAMBLE
摘要:The present invention provides synthetic routes for preparing various isomers of cyclohexane-based coolants, such as menthyl esters and menthanecarboxamide derivatives, in particular those substituted at the amide nitrogen, for example with an aromatic ring or aryl moiety. Such structures have high cooling potency and long lasting sensory effect, which make them useful in a wide variety of consumer products. One synthetic route involves a copper catalyzed coupling of a primary menthanecarboxamide with an aryl halide, such reaction working best in the presence of potassium phosphate and water. Using this synthetic route, specific isomers can be prepared including the menthanecarboxamide isomer having the same configuration as l-menthol and new isomers such as a neoisomer having opposite stereochemistry at the carboxamide (C-1) position. The neoisomer unexpectedly has potent and long lasting cooling effect. Preparation schemes for neoisomers of other menthyl derivatives which are useful as coolants, including esters, ethers, carboxy esters and other N-substituted carboxamides are also provided.

专利号:US-9950991-B2
优先权日:2013-11-05
标 题 :Process for the preparation of iopamidol
发明人：BATTISTINI ELISA; BUONSANTI FEDERICA; IMPERIO DANIELA; LATTUADA LUCIANO; NAPOLITANO ROBERTA
权利人:BRACCO IMAGING SPA
摘要:The present invention discloses a process for the preparation of Iopamidol of formula (II) and comprising the following steps: a) reacting the Compound (I) wherein X is OR2 or R3, and wherein R2 and R3 are a Ci-C6 linear or branched alkyl, C3-C6 cycloalkyl, C6 aryl, optionally substituted with a group selected from the group consisting of methyl, ethyl, n-propyl, i-propyl, n-butyl, sec-butyl, t-butyl and phenyl, with the acylating agent (S)-2-(acetyloxy)propanoyl chloride in a reaction medium to provide the acetyloxy derivative of Compound (I); b) hydrolyzing the intermediate from step a) with an aqueous solution at a pH comprised from 0 to 7, by adding water or a diluted alkaline solution such as sodium hydroxide or potassium hydroxide, freeing the hydroxyls from the boron-containing protective groups, obtaining the N—(S)-2-(acetyloxy)propanoyl derivative of Compound (II); c) alkaline hydrolysis to restore the (S)-2-(hydroxy)propanoyl group and to obtain Iopamidol (II) and optional recovery of the boron derivative from the solution obtained in step b). The boron-containing protective group is versatile, efficient and recyclable. A one-pot synthesis, without intermediate isolation is provided, leading to a decreasing of recovered and recycled solvents and a significant increasing in the yield, representing a significant advantage in terms of cost-effectiveness of the entire process and environmental awareness.