CAS: 400-38-4; Isopropyltrifluoroacetate

相似化合物

400-52-2 431-47-0 407-38-5

上下游产品

CAS号74-98-6 丙烷 | CAS号407-25-0 三氟乙酸酐(TFAH) | CAS号1641-69-6 C13取代的一氧化碳 | CAS号76-05-1 三氟乙酸(TFA) | CAS号67-63-0 异丙醇 | CAS号368-66-1 2,4,6-三(三氟甲基)-1... | CAS号75-28-5 异丁烷 | CAS号201230-82-2 carbon monoxide | CAS号83566-43-2 tetraphenylbism... | CAS号433-28-3 三氟乙酸乙烯酯 | CAS号76-05-1 三氟乙酸(TFA) | CAS号75-89-8 三氟乙醇 | CAS号67-63-0 异丙醇 | CAS号720-94-5 4,4,4-三氟-1-(4-甲... | CAS号86571-26-8 1,1,1-trifluoro...

2-碘代丙烷 以40%的收率获得产物
参考文献:Zefirov,N. S.;Zhdankin,V. V.;Kozmin,A. S.,Izv. An Cccp. Cep. Xim.,1983,N 7,1682
标题:Zefirov,N. S.;Zhdankin,V. V.;Kozmin,A. S.,Izv. An Cccp. Cep. Xim.,1983,N 7,1682

专利信息

专利号:US-6140515-A
优先权日:1997-09-24
标题 :Process of making 3-aryloxy, 4-aryl furan-2-ones useful as inhibitors of COX-2
发明人：CHEN CHENG Y; TAN LUSHI; LARSEN ROBERT D
权利人:MERCK & CO INC
摘要:Described is a process of preparing 3-aryl, 4-aryloxy furan-5-ones which are useful as inhibitors of cyclooxygenase-2 (COX-2). Such compounds are useful as anti-inflammatory agents. The process is directed to an asymmetric synthesis which involves: a trisubstituted styrene derivative preparation via Horner-Wadsworth-Emmons reaction and subsequent one pot trifluoromethylation of the allylic alcohol; preparation of the alpha -hydroxyl ketone using Sharpless asymmetric dihydroxylation and Swern oxidation; the esterification of the alpha -hydroxyl ketone with the phenoxy acetic acid; and the Dieckman condensation of the resulting ester.

专利号:CN-108586399-B
优先权日:2018-07-03
标题 :Synthesis method of feloxicib