CAS: 40248-84-8; 3-Hydroxybenzenethiol

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CAS号15570-12-4 3-甲氧基苯硫酚 | CAS号21101-56-4 3,3'-二羟基二苯二硫醚 | CAS号22948-02-3 3-氨基苯硫酚 | CAS号56157-93-8 3-hydroxybenzen... | CAS号591-20-8 3-溴苯酚 | CAS号36971-28-5 (3-溴苯氧基)三甲基硅烷 | CAS号7647-01-0 盐酸 | CAS号21101-56-4 3,3'-二羟基二苯二硫醚 | CAS号127906-79-0 2-(3-hydroxyphe... | CAS号3463-03-4 3-(甲硫基)苯酚 | CAS号951238-24-7 [2-acetamido-2-... | CAS号951238-25-8 N-乙酰基-二-O-乙酰基KRP-203 | CAS号581-30-6 吩噻嗪-3-酮

3-羟基苯磺酰氯置于磷化氢,碘,溶剂黄146,水体系中,化学反应 2.0H,以81%的收率获得产物3-羟基苯硫酚
参考文献:Improved 3-Hydroxythiophenol Synthesis
标题:Improved 3-Hydroxythiophenol Synthesis
摘要:Hydroxythiophenols Have Provided Access To A Number Of Unique Heterocycles. Historically,Access To 3-Hydroxythiophenol Has Been Challenging Because Of Inefficiencies And Prohibitive Cost. A Straightforward And Efficient Route To 3-Hydroxythiphenol Has Been Devised.
DOI:10.1080/00397911.2011.611921

专利信息

专利号:US-2006128930-A1
优先权日:2004-12-03
标题 :Synthesis of sterically hindered phenol based macromolecular antioxidants
发明人：DHAWAN ASHISH; CHOLLI ASHOK L
权利人:DHAWAN ASHISH; CHOLLI ASHOK L
摘要:Disclosed is a method for the synthesis of sterically hindered polymeric antioxidants based on phenol type antioxidant monomers. The method includes polymerizing and alkylating a phenol containing monomer represented by the following structural formula: n n nto produce a sterically hindered polymeric macromolecular antioxidant. X, R 10 and q are as defined herein. The disclosed method is a simple, direct and economical process for the synthesis of sterically hindered polymeric macromolecular antioxidants.

专利号:US-7678877-B2
优先权日:2004-12-03
标题 :Process for the synthesis of polyalkylphenol antioxidants
发明人：YANG SUIZHOU; CHOLLI ASHOK L
权利人:POLNOX CORP
摘要:Disclosed is a method for the synthesis of sterically hindered polymeric antioxidants based on phenol type antioxidant monomers. The method includes partially etherifying, polymerizing and thermally rearranging a phenol containing monomer represented by the following structural formula: n nto produce a sterically hindered polymeric macromolecular antioxidant. X, R 10 and q are as defined herein. The disclosed method is a simple, direct and economical process for the synthesis of sterically hindered polymeric macromolecular antioxidants.

专利号:US-7674881-B2
优先权日:2005-10-07
标题:Convergent synthesis of proteins by kinetically controlled ligation
发明人：KENT STEPHEN; PENTELUTE BRAD; BANG DUHEE; JOHNSON ERIK; DUREK THOMAS
权利人:UNIV CHICAGO
摘要:The present invention concerns methods and compositions for synthesizing a polypeptide using kinetically controlled reactions involving fragments of the polypeptide for a fully convergent process. In more specific embodiments, a ligation involves reacting a first peptide having a protected cysteyl group at its N-terminal and a phenylthioester at its C-terminal with a second peptide having a cysteine residue at its N-termini and a thioester at its C-termini to form a ligation product. Subsequent reactions may involve deprotecting the cysteyl group of the resulting ligation product and/or converting the thioester into a thiophenylester.

专利号:WO-2024261784-A1
优先权日:2023-06-22
标题:Organometallic complexes and compounds of mercaptophenols and curcumin for therapeutic applications
发明人：GHOSH SUPRATIM
权利人:GHOSH SUPRATIM
摘要:The present disclosure discloses a group of organometallic complexes and compounds of curcumin and mercaptophenols with various metals having therapeutic potential and processes for the preparation thereof for the treatment of cancer and other diseases The present disclosure further discloses chemical strategy for synthesis of water soluble and stable formulations by bonding metal atom (M) or amino (-NH2) group to α-carbon atom, the carbon between two ionizable groups (-C=O / -OH / -SH) of phenolic molecules, curcumin or mercaptophenols for biomedical applications. The present disclosure provides for complexes that comprise bonding of metal (M) atoms either only to sulfur atom or oxygen atom of mercaptophenol molecule. The compounds and complexes are significantly beneficial for cancer therapy and treatment of other diseases, as they can inhibit disease causing cell proliferation and induce host immune system, and also could be administered in a prodrug form, avoiding the formation of toxic molecules.

专利号:US-2006128929-A1
优先权日:2004-12-03
标 题:Process for the synthesis of polyalkylphenol antioxidants

专利号:US-6476248-B1
优先权日:1998-12-18
标题:Hydroxythiol grignard reaction synthesis
发明人：RYCKMAN DAVID; ZHANG MINGBAO; CHEN GUOHUA
权利人:HONEYWELL INT INC
摘要:A method for the preparation of hydroxythiol compounds by reacting a hydroxyl-protected halide compound having the structure: n n n X—R—OPg n n n with magnesium in a Grignard-suitable solvent to form a hydroxyl-protected magnesium halide compound, wherein R is selected from substituted or unsubstituted aliphatic radicals, substituted or unsubstituted cyclic aliphatic radicals, substituted or unsubstituted aromatic radicals, substituted or unsubstituted araliphatic radicals and substituted or unsubstituted heterocyclic radicals; Pg is a protecting group; and X is selected from the group consisting of F, Cl, Br and I; then reacting said hydroxyl-protected magnesium halide compound with sulfur in the Grignard-suitable solvent to form a hydroxyl-protected thiomagnesium halide compound; and hydrolyzing the protected hydroxyl group to form a hydroxythiomagnesium halide compound and converting the thiomagnesium halide to a thiol; wherein the protecting group is selected so that species formed by the de-protection of the protecting group are inert toward thiols, or the method further includes the step of removing the protecting group species formed by de-protection of the hydroxyl group from the reaction mixture before converting the thiomagnesium halide to a thiol.