CAS: 553-21-9; (3As,6E,10E,11Ar)-6,10-Dimethyl-3-Methylene-3A,4,5,8,9,11A-Hexahydrocyclodeca[b]Furan-2(3H)-One

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CAS号29424-04-2 Naphtho[1,2-b]f...

Saussureamine A置于盐酸体系中,化学反应 12.0H,以100%的收率获得产物木香烃内酯
参考文献:绝对立体结构和saussureamines A的合成,B,C,D和e,氨基酸缀合物倍半萜与胃保护作用,从根云木香
标题:绝对立体结构和saussureamines A的合成,B,C,D和e,氨基酸缀合物倍半萜与胃保护作用,从根云木香
摘要:从五味子雪莲干燥根的甲醇提取物中,分离出五种氨基酸-倍半萜烯共轭物,五味子胺a,B,C,D和e,以及木脂糖苷,(-)-Massoniresinol 4"-ø-β-D-吡喃葡萄糖苷.它们的立体结构是根据化学和物理化学证据确定的.此外,使用氨基酸与倍半萜烯的α-亚甲基-γ-内酯部分的迈克尔型加成反应,合成了雪沙胺和相关的氨基酸-倍半萜烯共轭物.索绪尔胺a,B和c,木香内酯和脱氢古木酸内酯对大鼠的酸化乙醇诱导的胃粘膜损伤具有胃保护作用.鼠尾草胺a还对小鼠的水浸应激诱导的胃粘膜损伤表现出抑制作用.
DOI:10.1016/s0040-4020(00)00696-7

专利信息

专利号:US-11851651-B2
优先权日:2017-06-19
标 题 :Automated methods for scalable, parallelized enzymatic biopolymer synthesis and modification using microfluidic devices
发明人：BANAL JAMES; BERLEANT JOSEPH DON; SHEPHERD TYSON; BATHE MARK
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Methods for the automated template-free synthesis of user-defined sequence controlled biopolymers using microfluidic devices are described. The methods facilitate simultaneous synthesis of up to thousands of uniquely addressed biopolymers from the controlled movement and combination of regents as fluid droplets using microfluidic and EWOD-based systems. In some forms, biopolymers including nucleic acids, peptides, carbohydrates, and lipids are synthesized from step-wise assembly of building blocks based on a user-defined sequence of droplet movements. In some forms, the methods synthesize uniquely addressed nucleic acids of up to 1,000 nucleotides in length. Methods for adding, removing and changing barcodes on biopolymers are also provided. Biopolymers synthesized according to the methods, and libraries and databases thereof are also described. Modified biopolymers, including chemically modified nucleotides and biopolymers conjugated to other molecules are described.

专利号:US-2022162188-A1
优先权日:2019-01-15
标 题:Isoprenoids and methods of making thereof
发明人：WILLIAMS GAVIN; LUND SEAN; HALL RACHAEL
权利人:UNIV NORTH CAROLINA STATE
摘要:Disclosed are methods for preparing isoprenoid subunits, as well as methods of employing these isoprenoid subunits for the synthesis of isoprenoids. Also provided are isoprenoids prepared using the methods described herein.

专利号:US-2024287013-A1
优先权日:2021-06-10
标题 :A method for asymmetric synthesis of (-)- Anisomelic Acid

专利号:US-12435055-B2
优先权日:2019-08-06
标 题 :3-methylideneoxan-4-one compounds and substituted derivates thereof as inhibitors of telomerase
发明人：SCHEIDT KARL A; BETORI RICK C
权利人:UNIV NORTHWESTERN
摘要:Disclosed are 3-methylideneoxan-4-one compounds, derivatives thereof, and methods of their synthesis and methods of their use in treating a disease or disorder in a subject in need thereof, such as diseases and disorders that are associated with telomerase activity such as cancer. The disclosed compounds may be formulated in a pharmaceutical composition for treating diseases and disorders that are associated with telomerase activity such as cancer.

专利号:WO-2022257086-A1
优先权日:2021-06-10
标 题:Method for asymmetric synthesis of (–)-anisomelic acid

专利号:CN-117500794-A
优先权日:2021-06-10
标题:A kind of asymmetric synthesis method of (-)-hexic acid