CAS: 59142-68-6; 2-Bromo-4-Fluorobenzaldehyde

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CAS号79-37-8 草酰氯 | CAS号229027-89-8 2-溴-4-氟苄醇 | CAS号1006-41-3 2-溴-4-氟苯甲酸 | CAS号1422-53-3 2-溴-4-氟甲苯 | CAS号348-37-8 6-氟吲哚-2-甲酸乙酯 | CAS号43192-31-0 2-溴-4-甲氧基苯甲醛 | CAS号136818-43-4 6-氟吲哚-2-羧酸甲酯 | CAS号229027-89-8 2-溴-4-氟苄醇 | CAS号1226773-36-9 5-(Benzyloxy)-2... | CAS号1221445-02-8 6-fluoro-3-meth... | CAS号1221684-51-0 2-溴-1-乙烯基-4-氟苯 | CAS号1196474-68-6 4-(3-溴-4-甲酰基苯氧基... | CAS号1196473-37-6 1,3-二氢-1-羟基-2,1... | CAS号261711-20-0 1-(2-溴-4-氟苯基)乙醇

2-溴-4-氟苯甲腈置于二异丁基氢化铝,水体系中,用 甲苯,甲醇 作为反应溶剂,化学反应 12.0H,反应生成 2-溴-4-氟苯甲醛
参考文献:分子内氨基钯催化引发的钯与烯烃催化的钯催化成环氨基烯化反应
标题:分子内氨基钯催化引发的钯与烯烃催化的钯催化成环氨基烯化反应
摘要:描述了钯催化的氨基钯反应,然后与醛类进行亲核加成反应并脱水.这种直接且操作简单的方法为广泛的官能化四氢异喹啉具有高选择性提供了一种快速可靠的方法.机理研究表明,通过高度有序的过渡态进行的亲核加成是营业额限制步骤,其中关键csp 3-Pd物种固有的β-氢化物消除是受约束构象和亲核性控制的.氮原子的强供电子作用增强了csp 3-Pd键.
DOI:10.1002/anie.201611853

专利信息

专利号:US-2011301143-A1
优先权日:2009-02-23
标题 :Heterocyclic derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：ISABEL ELISE; LACHANCE NICOLAS; LECLERC JEAN-PHILIPPE; LEGER SERGE; OBALLA RENATA M; POWELL DAVID; RAMTOHUL YEEMAN K; ROY PATRICK; TRANMER GEOFFREY K; ASPIOTIS RENEE; LI LIANHAI; MARTINS EVELYN
权利人:ISABEL ELISE; LACHANCE NICOLAS; LECLERC JEAN-PHILIPPE; LEGER SERGE; OBALLA RENATA M; POWELL DAVID; RAMTOHUL YEEMAN K; ROY PATRICK; TRANMER GEOFFREY K; ASPIOTIS RENEE; LI LIANHAI; MARTINS EVELYN
摘要:Heterocyclic compounds of structural formula (I), or a pharmaceutically acceptable salt thereof, wherein W is a R1— substituted heteroaryl, R1 is an heteroaryl ring substituted with an ester or carboxylic acid containing radical, X-T is N—CR5R6, Câ•?CR5 or CR13—CR5R6, Y is a bond or —C(O)—, a and b represent an integer selected from 1 to 4, and Ar is an optionally substituted phenyl or naphtyl, are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD) The heterocyclic compounds are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, atherosclerosis, obesity, diabetes, neurological disease, Metabolic Syndrome, insulin resistance, cancer, liver steatosis, and non-alcoholic steatohepatitis.

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