专利号:US-5338851-A 优先权日:1993-03-31 标 题:Synthesis of cis-decahydroisoquinoline-3-carboxylic acids 发明人:HUFF BRET E; KHAU VIEN V; MARTINELLI MICHAEL J; PETERSON BARRY C 权利人:LILLY CO ELI 摘要:This invention provides a process for the synthesis of cis-decahydroisoquinoline-3-carboxylic acids and provides intermediates in the synthesis thereof.
专利号:US-4900828-A 优先权日:1988-05-12 标 题:Intermediate compounds and an improved procedure for the synthesis of 2',3'-dideoxycytidine 发明人:BELICA PETER S; HUANG TAI-NANG; MANCHAND PERCY S; PARTRIDGE JOHN J; TAM STEVE 权利人:HOFFMANN LA ROCHE 摘要:A method for the synthesis of 2',3'-dideoxycytidine comprising a novel procedure of bromoacetylating cytidine to yield novel intermediates which are subsequently reduced and hydrogenated by novel procedures to yield 2',3'-dideoxycytidine.
专利号:US-5461156-A 优先权日:1993-03-31 标 题 :Stereocontrolled synthesis of cis-bicyclic compounds 发明人:KHAU VIEN V; MARTINELLI MICHAEL J; PETERSON BARRY C; SULLIVAN KEVIN A 权利人:LILLY CO ELI 摘要:This invention provides a process for the stereocontrolled synthesis of cis-bicyclic compounds, including cis-hexahydro-6-isoquinolones, cis-dihydroisochromanones, cis-dihydrothiochromanones, and cisbicyclo[4.4.0]dec-3-ene-2-ones.
专利号:US-9267213-B1 优先权日:2005-03-25 标题:Electrochemical deblocking solution for electrochemical oligomer synthesis on an electrode array 发明人:MAURER KARL; COOPER JOHN J 权利人:CUSTOMARRAY INC 摘要:There is disclosed an electrochemical deblocking solution for use on an electrode microarray. There is further disclosed a method for electrochemical synthesis on an electrode array using the electrochemical deblocking solution. The solution and method are for removing acid-labile protecting groups for synthesis of oligonucleotides, peptides, small molecules, or polymers on a microarray of electrodes while substantially improving isolation of deblocking to active electrodes. The method comprises applying a voltage or a current to at least one electrode of an array of electrodes. The array of electrodes is covered by the electrochemical deblocking solution.
专利号:US-6218556-B1 优先权日:1996-11-12 标 题:Synthesis of a low trans-content edible oil, non-edible oil, or fatty acid in a solid polymer electrolyte reactor 发明人:PINTAURO PETER N 权利人:UNIV TULANE 摘要:An electrochemical process for hydrogenating an unsaturated fatty acid, mixtures of two or more fatty acids, or the unsaturated fatty acid constituents of an edible or non-edible oil's triglycerides is performed using a solid polymer electrolyte reactor. Membrane electrode assemblies consist of a cation exchange membrane onto which porous anode and cathode electrodes are attached. As the electrodes are permeable, reactant and products enter and leave the membrane/cathode and membrane/anode reaction zones via the back sides of the electrodes. Hydrogen is generated in situ by the electro-reduction of protons that are formed at the anode and which migrate through the ion exchange membrane for reaction with the fifty acids or fatty acid constituents. In the disclosed process, only protons (H + ions) carry the current between the anode and the cathode. The need for a supporting electrolyte to conduct electricity has been circumvented. The disclosed process operates at a low to moderate temperature at atmospheric or moderate pressure without the use of a supporting electrolyte that will contaminate the oil. A novel partially hydrogenated oil product selected from the group consisting of a partially hydrogenated fatty acid, a partially hydrogenated triglyceride, and mixtures thereof is produced by the disclosed process. The product produced from the disclosed process has: a trans-isomer content lower than that of a similarly hydrogenated oil product formed in a high temperature chemical catalytic reaction process; a peroxide value of less than about 1.5%; free fatty acid content of less than about 0.02%; and, improved purity.
专利号:US-4337125-A 优先权日:1980-12-08 标 题:Electrochemical synthesis of organophosphorus compounds from the element 发明人:KUCK MARK A; MILLER GARY K 权利人:STAUFFER CHEMICAL CO 摘要:A process for the preparation of organophosphorus derivatives of organic hydroxyl or sulfhydryl compounds which includes the step of electrolyzing said organic hydroxyl or sulfhydryl compounds in an electrochemical cell having an anode comprising elemental phosphorus.