CAS: 13910-48-0; N1-Benzylpropane-1,3-Diamine

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127346-48-9 17400-34-9 6291-84-5

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CAS号706-03-6 3-(苄氨基)丙腈 | CAS号100-52-7 苯甲醛 | CAS号107-15-3 乙二胺 | CAS号109-76-2 1,3-丙二胺 | CAS号103-67-3 N-甲基苄胺 | CAS号100-44-7 氯化苄 | CAS号87142-90-3 3-(benzylidenea... | CAS号42245-33-0 N,N-dimethyl-2-... | CAS号100-46-9 苄胺 | CAS号1111643-89-0 N(1)-benzyl-N(1... | CAS号109-76-2 1,3-丙二胺

N-Benzyl-3-Chloropropan-1-Amine置于氨体系中,用 甲醇 用作溶剂,化学反应 3.0H,反应生成3-苄胺基丙胺
参考文献:一系列4-氨基-6,7-二甲氧基喹唑啉衍生物的合成及其降压活性.
标题:一系列4-氨基-6,7-二甲氧基喹唑啉衍生物的合成及其降压活性.
摘要:合成了一系列的n2-[(酰基氨基)烷基]-6,7-二甲氧基-2,4-喹唑啉二胺作为潜在的α1-肾上腺素受体拮抗剂.当以10 Mg / Kg Po自发性高血压大鼠给药时,许多丙烷二胺衍生物显示出非常好的降压活性,而乙二胺衍生物尽管在结构上与哌唑嗪密切相关,却缺乏该特性.活性最高的衍生物n-[3-[(4-氨基-6,7-二甲氧基-2-喹唑啉基)甲基氨基]丙基]四氢-2-呋喃甲酰胺x盐酸盐阿夫唑嗪(12)对外围α1具有很高的选择性.-结后肾上腺素受体.在等剂量的降压剂量下,其对清醒犬体位变化的升压反应的作用不如哌唑嗪所显示.根据这些结果,
Doi:10.1021/jm00151A003

专利信息

专利号:WO-0034226-A1
优先权日:1998-12-10
标 题 :Polyamine transport inhibitors
发明人：POULIN RICHARD; AUDETTE MARIE; CHAREST-GAUDREALT RENE
权利人:UNIV LAVAL; ILEX ONCOLOGY INC; POULIN RICHARD; AUDETTE MARIE; CHAREST GAUDREALT RENE
摘要:The application discloses synthetic derivatives of original polyamines in which a carbon atom to the original polyamine comprises an amide group inhibits the e cellular uptake of a natural polyamine by specifically binding a cellular transporter for a natural polyamine . The synthetic derivatives are used to inhibit the activity of a natural polyamine transporter, in the treatment of disorders involving unrestrained cell proliferation and/or differentiation where control of polyamine transport is required When used in combination with a n inhibitor of polyamine synthesis.

专利号:US-6949679-B1
优先权日:1998-04-21
标 题 :Polyamine transport inhibitors
发明人：POULIN RICHARD; AUDETTE MARIE; CHAREST-GAUDREAULT RENE
权利人:UNIV LAVAL
摘要:The present invention describes the design, synthesis and therapeutic use of a variety of novel inhibitors of polyamine transport. The main feature of this class of transport inhibitors is to incorporate a linker or side chain that prevents the uptake of polyamines and helps to conjugate polyamine analogs to form dimers with high inhibitory potency against polyamine uptake. These new compounds incorporate features that are designed to maximize their chemical and metabolic stability and their ability to bind to the polyamine transporter, and to minimize their toxicity by preventing their absorption by the cells. The purpose of such inhibitors is to prevent the uptake or salvaging of circulating polyamines by rapidly proliferating cells such as tumor cells, in order to potentiate the effect of therapeutic inhibitors of polyamine biosynthesis such as alpha-difluoromethylornithene.