专利号:US-4190579-A 优先权日:1977-12-29 标题:Synthesis of beta-lactams from azetidine carboxylic acid esters 发明人:LIPSHUTZ BRUCE H; WASSERMAN HARRY H; WU JAMES S 权利人:RESEARCH CORP 摘要:Azetidine carboxylic acid esters are converted into enol silyl ethers which, as enamino ketene acetals, undergo ready oxidative cleavage of the ethylenically unsaturated double bond, e.g. by dye-sensitized photo-oxygenation, to form beta-lactams. The beta-lactams and substitution products thereof are useful intermediates in the synthesis of biologically active lactams.
专利号:US-4288613-A 优先权日:1979-12-03 标 题:Cyclopentanone synthesis 发明人:LAROCK RICHARD C 权利人:UNIV IOWA STATE RES FOUND INC 摘要:A method of synthesis of cyclopentanones comprising cyclizing a 4-pentenal, preferably under an ethylene atmosphere, in the presence of a catalytically effective amount of a cyclizing, rhodium(I) para-substituted triarylphosphine catalyst.
专利号:US-3732214-A 优先权日:1970-07-16 标题 :Method for the synthesis of zeaxanthins,xanthophylls,and 3beta-carotene 发明人:SURMATIS J; WALSER A 权利人:HOFFMANN LA ROCHE 摘要:METHOD BY WHICH ZEAXANTHINS, XANTHOPYLLS AND 3-OXO-BCAROTENE CAN BE SYNTHESIZED FROM THE CONDENSATION PRODUCT OF MESITYL OXIDE AND ACETO-ACETIC ESTER AS WELL AS NEW AND NOVEL INTERMEDIATES PRODUCED IN THE SYNTHESIS. ZEAXANTHIN AND XANTHOPHYLL ARE KNOWN COLORING AGENTS FOR FOODSTUFFS, INCLUDING BEVERAGES, PHARMACEUTICAL AND COSMETIC PREPARATIONS. FURTHERMORE, THROUGH THE USE OF THE CONDENSATION PRODUCT OF MESITYL OXIDE AND ACETOACETIC ACID, NEW COMPOUNDS FOR COLORING FOODSTUFFS, INCLUDING BEVERAGES, PHARMACEUTICAL AND COSMETIC PREPARATIONS ARE PRODUCED.
专利号:US-2005004225-A1 优先权日:2003-04-16 标题:Oxidoreductase inhibitors and methods of screening and using thereof 发明人:BALENDIRAN GANESARATNAM K 摘要:The present invention relates to 1) the design and synthesis of analogs to glutathione conjugates which bind to or interact with aldose reductase (AR) through unique conformations that are distinctly different from the substrates and inhibitors of AR which are members of sugar metabolism; 2) the screening of the analogs to identify those that interact with or inhibit or enhance the activity of AR; and 3) the use of AR ligands, AR inhibitors (AR antagonsits) or AR enhancer (AR agonists) in the detection of AR activity, the modulation of AR activity, and the treatment of conditions in a subject in need of modulating AR activity. Such conditions include but not limited to cardiovascular disease, diabetes, artheriosclerosis, cancer, neoplasm, obesity, cataract, retinopathy, keratopathy, nephropathy, neurosis, thrombosis, faulty union of corneal injury and neuropathy. Examples of the treatment include the use of fibrates as AR inhibitors to treat these conditions.
专利号:US-2016068459-A1 优先权日:2013-04-19 标题 :Immobilized catalytically active composition for hydroformylation of olefin-containing mixtures 发明人:DYBALLA KATRIN MARIE; FRANKE ROBERT; HAHN HANNA; BECKER MARC; SCHOENWEIZ ANDREAS; DEBUSCHEWITZ JONAS; WALTER SIMON; WOELFEL RENE; HAUMANN MARCO; WASSERSCHEID PETER; KAFTAN ANDRE; LAURIN MATHIAS; LIBUDA JOERG 权利人:EVONIK DEGUSSA GMBH 摘要:A composition and the use of said composition as catalytically active composition in processes for synthesis of chemical compounds, especially the hydroformylation of olefinically unsaturated hydrocarbon mixtures.
专利号:US-5481040-A 优先权日:1994-03-31 标 题:Process for the preparation of phosphonium salts 发明人:FUKUMOTO TAKEHIKO; HIROKAWA KAZUSHI; OKADA KURAO 权利人:SHINETSU CHEMICAL CO 摘要:A process for the preparation of phosphonium salts by the use of chlorides, which is useful in the course of synthesis of olefin compounds by the Wittig reaction, and which comprises reacting a phosphine compound of the general formula R13P wherein R1 is a phenyl group or a straight-chain alkyl group having 2 to 8 carbon atoms, with a primary or secondary chloride of the general formula wherein R2 and R3 are hydrocarbon radicals, in a solvent selected from the group consisting of N,N-dimethylformamide, N,N-dimethylacetamide and N,N-1,3-dimethyl-2-imidazolidinone, and in the presence of an alkali metal salt of the general formula MBr or MI.
参考标题:Synthesis OfO-(Dimethylamino)Aryl Ketones And Acridones By The Reaction Of 1,1-Dialkylhydrazones And Arynes 作者:Anton V. Dubrovskiy,Richard C. Larock |发布日期:2011.8.5 摘要:A Novel, Efficient Route To Biologically And Pharmaceutically Important O-(Dimethylamino)Aryl Ketones And Acridones Has Been Developed Starting From Readily Available 1,1-Dimethylhydrazones Of Aldehydes And O-(Trimethylsilyl)Aryl Triflates. The Reaction Proceeds Under Mild Conditions, Tolerates A Wide Range Of Functional Groups, And Provides The Final Products In Good To Excellent Yields.
合成参考文献
摘要:Shimada, K., Science of Synthesis Knowledge Updates, (2010) 1, 435. 摘要:Kawęcki, R., Science of Synthesis Knowledge Updates, (2018) 4, 327. 摘要:Hunter, L., Science of Synthesis Knowledge Updates, (2017) 2, 433. 摘要:Nguyen, B. N.; Hii, K. K.; Szymański, W.; Janssen, D. B., Science of Synthesis: Stereoselective Synthesis, (2011) 1, 638. 摘要:MacMillan, D. W. C.; Watson, A. J. B., Science of Synthesis: Asymmetric Organocatalysis, (2012) 1, 385.