CAS: 1689-78-7; 2-(Tert-Butyl)Thiophene

该化合物是一种代用硫苯衍生物,其特点是在硫苯环的2位置上存在一个异丁基组,这种结构改变增强了其消毒和电子特性,使其成为有机合成和材料科学应用中的宝贵中间体.三丁基组具有更大的稳定性和影响反应力,特别是在电益替代反应中.这种化合物通常用于开发同质聚合物,催化用离心和功能化异血循环.其定义明确的分子结构及其与各种合成途径的兼容性,使它成为先进的化学研究和工业应用的多用途建筑块.

结构式图片

相似化合物

150483-87-7 4095-22-1 1566106-22-6

上下游产品

thiophene tertiary butyl chloride isobutene 2,2-dimethylpropane 1-[5-(1,1-Dimethylethyl)-2-thienyl]ethanone 5-(tert-butyl)thiophene-2-carboxylic acid 2-(1,1-Dimethylethyl)-5-(4-nitrophenyl)thiophene 5-tert.-butyl-thiophene-2-sulfonyl chloride

合成工艺路线路线简述

  • 合成目标产物 2-T-Butylthiophene 主要起始原料 Thiophene(Siv) (9CI) And 2-Bromo-2-Methylpropane
  • (文献来源)合成步骤主要原料 Thiophene(Siv) (9Ci) 和 2-Bromo-2-Methylpropane
2-溴-5-(1,1-二甲基乙基)-噻吩置于正丁基锂体系中,用 乙醚 用作溶剂,化学反应 1.0H,以3.44 G的收率获得2-叔丁基噻吩
参考文献:Stable Heteroareniumions-Viii Some Transformations Of Alkylthiophenium Ions And New Synthesis Of 2-T-Butylthiophene
标题:Stable Heteroareniumions-Viii Some Transformations Of Alkylthiophenium Ions And New Synthesis Of 2-T-Butylthiophene
摘要:
Doi:10.1016/s0040-4020(01)83499-2

专利信息


专利号:US-9353057-B2
优先权日:2003-12-30
标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
发明人:GALLOP MARK A; DAI XUEDONG; SCHEUERMAN RANDALL A; RAILLARD STEPHEN P; MANTHATI SURESH K; YAO FENMEI; PHAN THU; LUDWIKOW MARIA; PENG GE; BHAT SEEMA
权利人:XENOPORT INC
摘要:Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

专利号:US-2008086013-A1
优先权日:2006-06-15
标 题:Carbometallation of alkynes and improved synthesis of uniquinones
发明人:LIPSHUTZ BRUCE H
权利人:UNIV CALIFORNIA
摘要:Methods for the carbometallation of alkynes are presented. Those are useful for the synthesis of CoQ 10 and other ubiquinones as well as for the synthesis of ubiquinol analogs.

专利号:US-9988488-B2
优先权日:2013-03-26
标 题:Catalyst for poly(lactide) synthesis and uses thereof
发明人:CHAKRABORTY DEBASHIS; GHOSH SWARUP; RAMKUMAR VENKATACHALAM
权利人:INDIAN INSTITUTE OF TECH MADRAS
摘要:A catalysts for poly(lactide) synthesis having the structure of Formula I: n nwherein R 1 and R 2 is, independently, C 1 -C 6 alkoxy, and R 3 arylalkyl or substituted phenyl are disclosed. Method of synthesizing the catalysts and method of using the catalysts to prepare poly(lactides) and compositions comprising the catalyst are also disclosed.

专利号:US-12006540-B2
优先权日:2015-09-28
标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis
发明人:JU JINGYUE; LI XIAOXU; CHEN XIN; LI ZENGMIN; KUMAR SHIV; SHI SHUNDI; GUO CHENG; REN JIANYI; HSIEH MIN-KANG; CHIEN MINCHEN; TAO CHUANJUAN; ERTURK ECE; KALACHIKOV SERGEY; RUSSO JAMES J
权利人:UNIV COLUMBIA
摘要:Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.

专利号:US-11685712-B2
优先权日:2019-12-30
标 题 :Synthesis of monofunctional thiuram accelerator
发明人:SPILKER THOMAS FRANKLIN; Jin ji yang; FEHER FRANK J
权利人:GOODYEAR TIRE & RUBBER
摘要:The present invention provides a route for synthesizing monofunctional thiuram compounds that is safe, environmentally friendly, and cost effective. This method specifically involves synthesizing a monofunctional thiuram by (1) reacting a tetraorganylthiuram disulfide with an organyl mercaptan to produce the monofunctional thiuram and a dithiocarbamate metal salt or a dithiocarbamate metalloid salt under basic conditions, (2) separating the monofunctional thiuram in an organic phase from the dithiocarbamate metal salt or the dithiocarbamate metalloid salt in an aqueous phase, and (3) recovering the monofunctional thiuram from the aqueous phase. The monofunctional thiuram compounds made in accordance with this invention are of particular value as accelerators for use in the vulcanization of rubber. The use of these monofunctional thiuram compounds as accelerators provides good cure rates and as well as good scorch safety.

专利号:US-2022267323-A1
优先权日:2019-07-23
标题 :Synthesis of bicyclic inhibitors of histone deacetylase
发明人:FULLER NATHAN OLIVER; HEWITT MICHAEL CHARLES; ASSELIN SYLVIE M; LUKE WAYNE DOUGLAS
权利人:ALKERMES INC
摘要:Provided herein are synthetic methods for the preparation of compounds having the Formula: (I) and (I′) and salts thereof.
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📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献


参考文献:10.1007/bf00534263
摘要:Belen'kii LI, Gromova GP, Krayushkin MM. Synthesis and electrophilic trichloromethylation of 2,4-dialkylthiophenes. Some transformations of 2,4-di-tert-butyl-5-(trichloromethyl)thiophene. Chemistry of Heterocyclic Compounds. 1993 Aug;29(8):883–8. doi: 10.1007/bf00534263.
参考文献:10.1007/pl00021990|10.1007/s10975-005-0013-z|10.1007/s10975-005-0050-7|10.1007/s10975-005-0051-6
摘要:Tsodikov MV, Kugel’ VY, Yandieva FA, Kliger GA, Glebov LS, Mikaya AI, Zaikin VG, Slivinskii EV, Plate NA, Gekhman AE, Moiseev II. Reductive dehydration of alcohols: A route to alkanes. Kinetics and Catalysis. 2004 Nov;45(6):854–66. doi: 10.1007/s10975-005-0013-z.
参考文献:10.1007/bf00529331
摘要:Belen'kii LI. Chemistry of thiophenium ions. Chemistry of Heterocyclic Compounds. 1992 Jun;28(6):610–8. doi: 10.1007/bf00529331.
参考文献:10.1023/a:1017586630491
摘要:Lukevics E, Stradins J, Skorova A. Yakov Lazarevich Gol'dfarb (On His 100th Birthday). Chemistry of Heterocyclic Compounds. 2001 Feb;37(2):133–40. doi: 10.1023/a:1017586630491.
参考文献:10.1007/bf00473076
摘要:Fabrichnyi BP, Shalavina IF, Kostrova SM, Gol'dfarb YL. Deacylation of aromatic ketones. Chemistry of Heterocyclic Compounds. 1971 Feb;7(2):165–7. doi: 10.1007/bf00473076.
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