2-溴-5-(1,1-二甲基乙基)-噻吩置于正丁基锂体系中,用 乙醚 用作溶剂,化学反应 1.0H,以3.44 G的收率获得2-叔丁基噻吩 参考文献:Stable Heteroareniumions-Viii Some Transformations Of Alkylthiophenium Ions And New Synthesis Of 2-T-Butylthiophene 标题:Stable Heteroareniumions-Viii Some Transformations Of Alkylthiophenium Ions And New Synthesis Of 2-T-Butylthiophene 摘要: Doi:10.1016/s0040-4020(01)83499-2
专利信息
专利号:US-9353057-B2 优先权日:2003-12-30 标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof 发明人:GALLOP MARK A; DAI XUEDONG; SCHEUERMAN RANDALL A; RAILLARD STEPHEN P; MANTHATI SURESH K; YAO FENMEI; PHAN THU; LUDWIKOW MARIA; PENG GE; BHAT SEEMA 权利人:XENOPORT INC 摘要:Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.
专利号:US-2008086013-A1 优先权日:2006-06-15 标 题:Carbometallation of alkynes and improved synthesis of uniquinones 发明人:LIPSHUTZ BRUCE H 权利人:UNIV CALIFORNIA 摘要:Methods for the carbometallation of alkynes are presented. Those are useful for the synthesis of CoQ 10 and other ubiquinones as well as for the synthesis of ubiquinol analogs.
专利号:US-9988488-B2 优先权日:2013-03-26 标 题:Catalyst for poly(lactide) synthesis and uses thereof 发明人:CHAKRABORTY DEBASHIS; GHOSH SWARUP; RAMKUMAR VENKATACHALAM 权利人:INDIAN INSTITUTE OF TECH MADRAS 摘要:A catalysts for poly(lactide) synthesis having the structure of Formula I: n nwherein R 1 and R 2 is, independently, C 1 -C 6 alkoxy, and R 3 arylalkyl or substituted phenyl are disclosed. Method of synthesizing the catalysts and method of using the catalysts to prepare poly(lactides) and compositions comprising the catalyst are also disclosed.
专利号:US-12006540-B2 优先权日:2015-09-28 标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis 发明人:JU JINGYUE; LI XIAOXU; CHEN XIN; LI ZENGMIN; KUMAR SHIV; SHI SHUNDI; GUO CHENG; REN JIANYI; HSIEH MIN-KANG; CHIEN MINCHEN; TAO CHUANJUAN; ERTURK ECE; KALACHIKOV SERGEY; RUSSO JAMES J 权利人:UNIV COLUMBIA 摘要:Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.
专利号:US-11685712-B2 优先权日:2019-12-30 标 题 :Synthesis of monofunctional thiuram accelerator 发明人:SPILKER THOMAS FRANKLIN; Jin ji yang; FEHER FRANK J 权利人:GOODYEAR TIRE & RUBBER 摘要:The present invention provides a route for synthesizing monofunctional thiuram compounds that is safe, environmentally friendly, and cost effective. This method specifically involves synthesizing a monofunctional thiuram by (1) reacting a tetraorganylthiuram disulfide with an organyl mercaptan to produce the monofunctional thiuram and a dithiocarbamate metal salt or a dithiocarbamate metalloid salt under basic conditions, (2) separating the monofunctional thiuram in an organic phase from the dithiocarbamate metal salt or the dithiocarbamate metalloid salt in an aqueous phase, and (3) recovering the monofunctional thiuram from the aqueous phase. The monofunctional thiuram compounds made in accordance with this invention are of particular value as accelerators for use in the vulcanization of rubber. The use of these monofunctional thiuram compounds as accelerators provides good cure rates and as well as good scorch safety.
专利号:US-2022267323-A1 优先权日:2019-07-23 标题 :Synthesis of bicyclic inhibitors of histone deacetylase 发明人:FULLER NATHAN OLIVER; HEWITT MICHAEL CHARLES; ASSELIN SYLVIE M; LUKE WAYNE DOUGLAS 权利人:ALKERMES INC 摘要:Provided herein are synthetic methods for the preparation of compounds having the Formula: (I) and (I′) and salts thereof.